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Platelet-rich plasma in the management of Asherman syndrome: case report

  • Reproductive Physiology and Disease
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References

  1. Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9(12):e1001356. https://doi.org/10.1371/journal.pmed.1001356.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Leke RJ, Oduma JA, Bassol-Mayagoitia S, Bacha AM, Grigor KM. Regional and geographical variations in infertility: effects of environmental, cultural, and socioeconomic factors. Environ Health Perspect. 1993;101(Suppl 2):73–80.

    Article  PubMed  PubMed Central  Google Scholar 

  3. March CM. Intrauterine adhesions. Obstet Gynecol Clin N Am. 1995;22(3):491–505.

    CAS  Google Scholar 

  4. Adoni A, Palti Z, Milwidsky A, Dolberg M. The incidence of intrauterine adhesions following spontaneous abortion. Int J Fertil. 1982;27(2):117–8.

    PubMed  CAS  Google Scholar 

  5. Touboul C, Fernandez H, Deffieux X, Berry R, Frydman R, Gervaise A. Uterine synechiae after bipolar hysteroscopic resection of submucosal myomas in patients with infertility. Fertil Steril. 2009;92(5):1690–3. https://doi.org/10.1016/j.fertnstert.2008.08.108.

    Article  PubMed  Google Scholar 

  6. Taskin O, Sadik S, Onoglu A, Gokdeniz R, Erturan E, Burak F, et al. Role of endometrial suppression on the frequency of intrauterine adhesions after resectoscopic surgery. J Am Assoc Gynecol Laparosc. 2000;7(3):351–4.

    Article  PubMed  CAS  Google Scholar 

  7. Berman JM. Intrauterine adhesions. Semin Reprod Med. 2008;26(4):349–55. https://doi.org/10.1055/s-0028-1082393.

    Article  PubMed  Google Scholar 

  8. Bukulmez O, Yarali H, Gurgan T. Total corporal synechiae due to tuberculosis carry a very poor prognosis following hysteroscopic synechialysis. Hum Reprod. 1999;14(8):1960–1.

    Article  PubMed  CAS  Google Scholar 

  9. Sharma JB, Roy KK, Pushparaj M, Gupta N, Jain SK, Malhotra N, et al. Genital tuberculosis: an important cause of Asherman's syndrome in India. Arch Gynecol Obstet. 2008;277(1):37–41. https://doi.org/10.1007/s00404-007-0419-0.

    Article  PubMed  Google Scholar 

  10. Practice Committee of American Society for Reproductive M. Current evaluation of amenorrhea. Fertil Steril. 2008;90(5 Suppl):S219–25. https://doi.org/10.1016/j.fertnstert.2008.08.038.

    Article  Google Scholar 

  11. Schenker JG. Etiology of and therapeutic approach to synechia uteri. Eur J Obstet Gynecol Reprod Biol. 1996;65(1):109–13.

    Article  PubMed  CAS  Google Scholar 

  12. Yang JH, Chen MJ, Chen CD, Chen SU, Ho HN, Yang YS. Optimal waiting period for subsequent fertility treatment after various hysteroscopic surgeries. Fertil Steril. 2013;99(7):2092–6 e3. https://doi.org/10.1016/j.fertnstert.2013.01.137.

    Article  PubMed  Google Scholar 

  13. Yu D, Li TC, Xia E, Huang X, Liu Y, Peng X. Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherma’'s syndrome. Fertil Steril. 2008;89(3):715–22. https://doi.org/10.1016/j.fertnstert.2007.03.070.

    Article  PubMed  Google Scholar 

  14. Myers EM, Hurst BS. Comprehensive management of severe Asherman syndrome and amenorrhea. Fertil Steril. 2012;97(1):160–4. https://doi.org/10.1016/j.fertnstert.2011.10.036.

    Article  PubMed  Google Scholar 

  15. Lin X, Wei M, Li TC, Huang Q, Huang D, Zhou F, et al. A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study. Eur J Obstet Gynecol Reprod Biol. 2013;170(2):512–6. https://doi.org/10.1016/j.ejogrb.2013.07.018.

    Article  PubMed  CAS  Google Scholar 

  16. Orhue AA, Aziken ME, Igbefoh JO. A comparison of two adjunctive treatments for intrauterine adhesions following lysis. Int J Gynaecol Obstet. 2003;82(1):49–56.

    Article  PubMed  CAS  Google Scholar 

  17. Johary J, Xue M, Zhu X, Xu D, Velu PP. Efficacy of estrogen therapy in patients with intrauterine adhesions: systematic review. J Minim Invasive Gynecol. 2014;21(1):44–54. https://doi.org/10.1016/j.jmig.2013.07.018.

    Article  PubMed  Google Scholar 

  18. Fernandez H, Al-Najjar F, Chauveaud-Lambling A, Frydman R, Gervaise A. Fertility after treatment of Asherman’s syndrome stage 3 and 4. J Minim Invasive Gynecol. 2006;13(5):398–402. https://doi.org/10.1016/j.jmig.2006.04.013.

    Article  PubMed  Google Scholar 

  19. Pabuccu R, Atay V, Orhon E, Urman B, Ergun A. Hysteroscopic treatment of intrauterine adhesions is safe and effective in the restoration of normal menstruation and fertility. Fertil Steril. 1997;68(6):1141–3.

    Article  PubMed  CAS  Google Scholar 

  20. Fedele L, Bianchi S, Frontino G. Septums and synechiae: approaches to surgical correction. Clin Obstet Gynecol. 2006;49(4):767–88. https://doi.org/10.1097/01.grf.0000211948.36465.a6.

    Article  PubMed  Google Scholar 

  21. Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, Giudice LC. In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration. J Assist Reprod Genet. 2018. https://doi.org/10.1007/s10815-018-1130-8.

  22. Tsapanos VS, Stathopoulou LP, Papathanassopoulou VS, Tzingounis VA. The role of Seprafilm bioresorbable membrane in the prevention and therapy of endometrial synechiae. J Biomed Mater Res. 2002;63(1):10–4.

    Article  PubMed  CAS  Google Scholar 

  23. Acunzo G, Guida M, Pellicano M, Tommaselli GA, Di Spiezio Sardo A, Bifulco G, et al. Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study. Hum Reprod. 2003;18(9):1918–21.

    Article  PubMed  CAS  Google Scholar 

  24. Amer MI, Abd-El-Maeboud KH, Abdelfatah I, Salama FA, Abdallah AS. Human amnion as a temporary biologic barrier after hysteroscopic lysis of severe intrauterine adhesions: pilot study. J Minim Invasive Gynecol. 2010;17(5):605–11. https://doi.org/10.1016/j.jmig.2010.03.019.

    Article  PubMed  Google Scholar 

  25. Santamaria X, Cabanillas S, Cervello I, Arbona C, Raga F, Ferro J, et al. Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study. Hum Reprod. 2016;31(5):1087–96. https://doi.org/10.1093/humrep/dew042.

    Article  PubMed  CAS  Google Scholar 

  26. Nagori CB, Panchal SY, Patel H. Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman’s syndrome. J Hum Reprod Sci. 2011;4(1):43–8. https://doi.org/10.4103/0974-1208.82360.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Lacci KM, Dardik A. Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med. 2010;83(1):1–9.

    PubMed  PubMed Central  CAS  Google Scholar 

  28. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. Am J Sports Med. 2014;42(3):610–8. https://doi.org/10.1177/0363546513518416.

    Article  PubMed  Google Scholar 

  29. Jo CH, Shin JS, Lee YG, Shin WH, Kim H, Lee SY, et al. Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears: a randomized, single-blind, parallel-group trial. Am J Sports Med. 2013;41(10):2240–8. https://doi.org/10.1177/0363546513497925.

    Article  PubMed  Google Scholar 

  30. Cervelli V, Gentile P, Scioli MG, Grimaldi M, Casciani CU, Spagnoli LG, et al. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods. 2009;15(4):625–34. https://doi.org/10.1089/ten.TEC.2008.0518.

    Article  PubMed  CAS  Google Scholar 

  31. Oh DS, Cheon YW, Jeon YR, Lew DH. Activated platelet-rich plasma improves fat graft survival in nude mice: a pilot study. Dermatol Surg. 2011;37(5):619–25. https://doi.org/10.1111/j.1524-4725.2011.01953.x.

    Article  PubMed  CAS  Google Scholar 

  32. Picard F, Hersant B, Bosc R, Meningaud JP. The growing evidence for the use of platelet-rich plasma on diabetic chronic wounds: a review and a proposal for a new standard care. Wound Repair Regen. 2015;23(5):638–43. https://doi.org/10.1111/wrr.12317.

    Article  PubMed  Google Scholar 

  33. Tehranian A, Esfehani-Mehr B, Pirjani R, Rezaei N, Sadat Heidary S, Sepidarkish M. Application of autologous platelet-rich plasma (PRP) on wound healing after caesarean section in high-risk patients. Iran Red Crescent Med J. 2016;18(7):e34449. https://doi.org/10.5812/ircmj.34449.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Castellani D, Valloni A, Piccirilli A, Paradiso Galatioto G, Vicentini C. An innovative approach to treating vaginal mesh exposure after abdominal sacral colpopexy: endoscopic resection of mesh and platelet-rich plasma; initial experience in three women. Int Urogynecol J. 2017;28(2):325–7. https://doi.org/10.1007/s00192-016-3154-x.

    Article  PubMed  Google Scholar 

  35. Langer HF, Stellos K, Steingen C, Froihofer A, Schonberger T, Kramer B, et al. Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro. J Mol Cell Cardiol. 2009;47(2):315–25. https://doi.org/10.1016/j.yjmcc.2009.03.011.

    Article  PubMed  CAS  Google Scholar 

  36. Stellos K, Seizer P, Bigalke B, Daub K, Geisler T, Gawaz M. Platelet aggregates-induced human CD34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro. Semin Thromb Hemost. 2010;36(2):139–45. https://doi.org/10.1055/s-0030-1251497.

    Article  PubMed  CAS  Google Scholar 

  37. Gawaz M, Vogel S. Platelets in tissue repair: control of apoptosis and interactions with regenerative cells. Blood. 2013;122(15):2550–4. https://doi.org/10.1182/blood-2013-05-468694.

    Article  PubMed  CAS  Google Scholar 

  38. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med. 2015;8(1):1286–90.

    PubMed  PubMed Central  CAS  Google Scholar 

  39. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod. 2017;21(1):54–6. https://doi.org/10.5935/1518-0557.20170013.

    Article  PubMed  PubMed Central  Google Scholar 

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Aghajanova, L., Cedars, M.I. & Huddleston, H.G. Platelet-rich plasma in the management of Asherman syndrome: case report. J Assist Reprod Genet 35, 771–775 (2018). https://doi.org/10.1007/s10815-018-1135-3

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