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Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder

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Abstract

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.

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Acknowledgments

The authors would like to thank the participants and their families for their support. Quentin Davis and Joshua Santosa of LKC Technologies for programming the RETeval custom protocol.

Funding

This work was funded by research grants from the Alan B Slifka Foundation, National Institute of Health U19 MH108206, and National Institute for Health Research R01 MH100173.

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Authors and Affiliations

  1. Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia

    Paul A. Constable

  2. Professor Emeritus, UCLA, Los Angeles, CA, USA

    Edward R. Ritvo

  3. Child Study Center, Yale University School of Medicine, New Haven, CT, USA

    Ariella R. Ritvo & James C. McPartland

  4. Behavioural and Brain Sciences Unit, Population Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK

    Irene O. Lee & David H. Skuse

  5. Department of Psychology, Stony Brook University, New York, NY, USA

    Morgan L. McNair

  6. School of Medicine, Washington University, St Louis, MO, USA

    Dylan Stahl

  7. NIHR Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK

    Jane Sowden

  8. Department of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Melbourne, Australia

    Stephen Quinn

  9. The Tony Kriss Visual Electrophysiology Unit, Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Trust, London, UK

    Dorothy A. Thompson

  10. UCL Great Ormond Street Institute of Child Health, University College London, London, UK

    Dorothy A. Thompson

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  1. Paul A. Constable
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Constable, P.A., Ritvo, E.R., Ritvo, A.R. et al. Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder. J Autism Dev Disord 50, 2874–2885 (2020). https://doi.org/10.1007/s10803-020-04396-5

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