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Effect of neuroprotective citicoline eye drops on macular microcirculation

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Abstract

Background and objective

To use optical coherence tomography (OCTA) examination of the retinal microvascular structures to evaluate the effect of neuroprotective eye drops (citicoline, OMK1®) administered for laser in situ keratomileusis (LASIK) surgery.

Patients and methods

This prospective study included 45 patients treated with citicoline after LASIK and 48 patients not treated with citicoline after LASIK as a control group. In both groups, the foveal avascular zone (FAZ), retinal superficial vascular density (SVD), and deep vascular density (DVD) in the foveal and parafoveal areas were measured preoperatively and at 1 and 3 months postoperatively using OCTA.

Results

No significant difference was detected between the groups in terms of preoperative SVD or DVD in the foveal and parafoveal zones and all quadrants (superior, inferior, temporal, and nasal) (P > 0.05). Similarly, no significant difference was detected between the citicoline group and control group in terms of SVD or DVD in the foveal and parafoveal zones at 1 and 3 months after LASIK (P > 0.05).

Conclusions

Despite their neuroprotective effect, topical citicoline drops had no significant effect on the superficial and deep microvascular structures of the retina or choriocapillaris.

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Acknowledgements

The authors did not receive grand and honorarium for this study. The study was approved by University Ethics Committee (protocol no. 2-18/b/2018). The work has not been presented in any meeting.

Funding

No financial support was received for this submission. The work has not been presented in any meeting.

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Correspondence to Esat Cinar.

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None of the authors has conflict of interest with the submission.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

All participants enrolled in this prospective study were informed about the study in detail according to the Declaration of Helsinki. The study was approved by the Alaaddin Keykubat University Ethics Committee (protocol no. 2-18/b/2018).

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Cinar, E., Yuce, B., Aslan, F. et al. Effect of neuroprotective citicoline eye drops on macular microcirculation. Int Ophthalmol 40, 2237–2246 (2020). https://doi.org/10.1007/s10792-020-01404-6

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  • DOI: https://doi.org/10.1007/s10792-020-01404-6

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