Skip to main content

Advertisement

SpringerLink
Log in

Diabetes and pachymetry changes in pregnancy

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Background

Purpose of this study is to evaluate changes in the central corneal thickness (CCT) in patients during the third trimester and postpartum phases of normal pregnancy, pregestational diabetes mellitus (DM), and gestational diabetes mellitus (GDM).

Methods

This was a prospective study. Patients that fulfilled the inclusion criteria were recruited from the obstetric clinic. They were grouped into normal pregnancy, pregestational DM, and GDM. Ophthalmic assessment and haematological investigations were done during the third trimester (after 28 weeks of gestation) and in the postpartum phase (6 weeks postpartum).

Results

A total of 192 pregnant patients were recruited for this study. Out of the 192 patients, only 143 of them came back for their follow-up 6 weeks postpartum. A total of 70 (36.5%) normal pregnancy patients, 51 (26.6%) DM patients, and 71 (36.9%) GDM patients were included in this prospective study. Our study showed that the CCT decreased postpartum in all three groups. Patients in all three groups did not have significantly different CCT during the third trimester of pregnancy and postpartum phase. However, patients who had thicker CCT irrespective of the grouping during the third trimester also had a thicker CCT post-delivery (p value <0.001). However, these changes did not appear to affect refractive error and visual acuity.

Conclusions

Diabetes mellitus during pregnancy did not appear to influence the CCT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Kuhl D, Schwarts SG, Sheth BP, Mieler WF (2013) Ocular manifestations of pregnancy. In: Arévalo, JF (ed) Retinal and choroidal manifestations of selected systemic diseases. Springer, New York, pp 465–477

    Google Scholar 

  2. Dinn RB, Harris A, Marcus PS (2003) Ocular changes in pregnancy. Obstet Gynaecol Surv 58(2):137–144

  3. Grant AD, Sophia M (2013) The eye in pregnancy: ophthalmologic and neuroophthalmologic changes. Clin Obstet Gynaecol 56(2):397–412

    Article  Google Scholar 

  4. Weinreb RN, Lu A, Beeson C (1988) Maternal corneal thickness during pregnancy. Am J Ophthalmol 105:258–260

    Article  CAS  PubMed  Google Scholar 

  5. Aydin E, Demir HD, Demirtuk F (2007) Corneal topographic changes in premenopausal and postmenopausal women. BMC Ophthalmol 7:9. doi:10.1186/1471-2415-7-9

    Article  PubMed  PubMed Central  Google Scholar 

  6. Suzuki T, Kinoshita Y, Tachibana M (2001) Expression of sex steroid hormone receptors in human cornea. Curr Eye Res 22:28–33

    Article  CAS  PubMed  Google Scholar 

  7. Storr-Paulsen A, Singh A, Jeppesen H (2014) Corneal endothelial morphology and central thickness in patients with type II diabetes mellitus. Acta Ophthalmol 92(2):158–160

    Article  PubMed  Google Scholar 

  8. Su DHW, Wong TY, Wong WL (2008) Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. Ophthalmology 115(6):964–968

    Article  PubMed  Google Scholar 

  9. Claramonte PJ, Ruiz-Moreno JM, Sanchez-Perez SI (2006) Variation of central corneal thickness in diabetic patients as detected by ultrasonic pachymetry. Arch Span Ophthalmol Soc 81:523–526

    CAS  Google Scholar 

  10. Scheler A, Spoer E, Boehm AG (2012) Effect of diabetes mellitus on corneal biomechanics and measurement of intraocular pressure. Acta Ophthalmol 90(6):447–451

    Article  Google Scholar 

Download references

Acknowledgements

Funding received from the Ophthalmology Department, University Malaya Medical Center, Malaysia—grant for research. No financial conflicts of interest involving any of the co-authors. We would like to acknowledge Mr. Vasu Devan from University Putra Malaysia for proofreading this manuscript.

Funding

This study was funded by University Malaya Grant Number E000058-20001 (LMD/RESEARCH 363/2012 & LMD/RESEARCH 364/2012).

Author information

Author notes

  1. Florence Santiagu

    Present address: Shah Alam Hospital, Persiaran Kayangan, Seksyen 7, 40000, Shah Alam, Selangor, Malaysia

Authors and Affiliations

  1. University Malaya Medical Center, Lembah Pantai, 59100, Kuala Lumpur, Malaysia

    Florence Santiagu, Azam Bakhtiari, Tajunisah Iqbal, Nurliza Khaliddin & Visvaraja Subrayan

  2. University of Miami, 1320 S Dixie Hwy, Coral Gables, FL, 33146, USA

    Van C. Lansingh

Authors
  1. Florence Santiagu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Azam Bakhtiari
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tajunisah Iqbal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nurliza Khaliddin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Van C. Lansingh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Visvaraja Subrayan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Florence Santiagu.

Ethics declarations

Conflict of interest

All authors declare that he/she has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethical MEC reference number 883.7 (University Malaya Ethics Committee).

Informed consent

Informed and written consent was obtained from each individual participants prior to the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Santiagu, F., Bakhtiari, A., Iqbal, T. et al. Diabetes and pachymetry changes in pregnancy. Int Ophthalmol 38, 2069–2076 (2018). https://doi.org/10.1007/s10792-017-0701-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-017-0701-5

Keywords

Search

Navigation