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Sensitivity and specificity of optical coherence tomography angiography (OCT-A) for detection of choroidal neovascularization in real-life practice and varying retinal expertise level

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Abstract

Purpose

To evaluate the diagnostic accuracy of OCT angiography (OCT-A) detecting or predicting choroidal neovascularization (CNV), by ophthalmologists of disparate degrees of skills in retinal diseases, using spectral domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) as a standard reference.

Methods

Retrospective observational case series. Patient presenting maculopathy and complete imaging were included. FA, SD-OCT, OCT-A and FA coupled to SD-OCT images were graded independently for presence or absence of CNV by ophthalmologists with varying expertise levels.

Results

Overall sensitivity of OCT-A was 85.62% (95% CI 79.04–90.76%) and specificity was 81.51% (95% CI 73.36–88.03). Sensitivity of FA was 74.51% (95% CI 66.84–81.20), and specificity was 82.35% (95% CI 74.30–88.73). Sensitivity of FA + SD-OCT was 92.72% (95% CI 87.34–96.30), and specificity was 90.91% (95% CI 84.31–95.37).

Conclusion

OCT-A has good sensitivity and specificity for the detection of CNV in all expertise level groups. OCT-A may soon become a routine tool for CNV diagnosis and follow-up.

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Authors and Affiliations

  1. Department of Ophthalmology, Créteil University Eye Clinic, Hôpital Intercommunal de Créteil, University Paris Est, 40 Avenue de Verdun, 94010, Créteil, France

    Vaël Souedan, Eric H. Souied, Violaine Caillaux, Alexandra Miere, Ala El Ameen & Rocio Blanco-Garavito

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  1. Vaël Souedan
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  2. Eric H. Souied
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  3. Violaine Caillaux
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  4. Alexandra Miere
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  5. Ala El Ameen
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  6. Rocio Blanco-Garavito
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Corresponding author

Correspondence to Rocio Blanco-Garavito.

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Conflict of interest

The authors declare not having received any grant support or research funding for the presser article. They also declare not having any proprietary interest in the materials described in the article.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Souedan, V., Souied, E.H., Caillaux, V. et al. Sensitivity and specificity of optical coherence tomography angiography (OCT-A) for detection of choroidal neovascularization in real-life practice and varying retinal expertise level. Int Ophthalmol 38, 1051–1060 (2018). https://doi.org/10.1007/s10792-017-0559-6

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  • DOI: https://doi.org/10.1007/s10792-017-0559-6

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