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Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly

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Abstract

Increased secretion of growth hormone and insulin-like growth factor-1 in acromegaly has various effects on multiple organs. However, the ocular effects of acromegaly have yet to be investigated in detail. The aim of the present study was to compare retina ganglion cell/inner plexiform layer (GCIPL) and peripapillary nerve fiber layer thickness (pRNFL) between patients with acromegaly and healthy control subjects using spectral domain optical coherence tomography (SD-OCT). This cross-sectional, comparative study included 18 patients with acromegaly and 20 control subjects. All participants underwent SD-OCT to measure pRNFL (in the seven peripapillary areas), GCIPL (in the nine ETDRS areas), and central macular thickness (CMT). Visual field (VF) examinations were performed using a Humphrey field analyzer in acromegalic patients. Measurements were compared between patients with acromegaly and control subjects. A total of 33 eyes of 18 patients with acromegaly and 40 eyes of 20 control subjects met the inclusion criteria of the present study. The overall calculated average pRNFL thickness was significantly lower in patients with acromegaly than in control subjects (P = 0.01), with pRNFL thickness significantly lower in the temporal superior and temporal inferior quadrants. Contrary to our expectations, pRNFL thickness in the nasal quadrant was similar between acromegalic and control subjects. The mean overall pRNFL thickness and superonasal, nasal, inferonasal, and inferotemporal quadrant pRNFL thicknesses were found to correlate with the mean deviation (MD) according to Spearman’s correlation. However, other quadrants were not correlated with VF sensitivity. No significant difference in CMT values was observed (P = 0.6). GCIPL thickness was significantly lower in all quadrants of the inner and outer macula, except for central and inferior outer quadrants, in the acromegaly group than that in the control group (P < 0.05). GCIPL thicknesses of the inferior inner and outer macula quadrants were found to correlate with MD, whereas no correlation was observed between other quadrants and VF sensitivity. We demonstrated that GCIPL thickness decreased in patients with acromegaly compared with that in control subjects. However, the nasal quadrant pRNFL thickness was similar in acromegaly, in contrast to our expectations. SD-OCT may have utility in the assessment of the effects of acromegaly on retinal structures.

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Acknowledgments

The authors thank Abdullah Kursat Cingu, MD, for his scientific assistance and critical revision of the paper.

Funding

The authors received no financial support for this study. The authors have no proprietary or financial interest in the products mentioned in this study.

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Dicle University, Diyarbakir, Turkey

    Muhammed Şahin, Alparslan Şahin, Harun Yüksel, Zeynep Gürsel Özkurt, Fatih Mehmet Türkcü & İhsan Çaça

  2. Department of Internal Medicine, Elazığ Training and Research Hospital, Elazıg, Turkey

    Faruk Kılınç

  3. Department of Internal Medicine, School of Medicine, Dicle University, Diyarbakir, Turkey

    Zafer Pekkolay & Hikmet Soylu

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  1. Muhammed Şahin
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  2. Alparslan Şahin
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Correspondence to Muhammed Şahin.

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Şahin, M., Şahin, A., Kılınç, F. et al. Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly. Int Ophthalmol 37, 591–598 (2017). https://doi.org/10.1007/s10792-016-0310-8

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  • DOI: https://doi.org/10.1007/s10792-016-0310-8

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