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Ventricular non-compaction review

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Abstract

Left ventricular non-compaction cardiomyopathy (LVNC) is a rare and unclassified cardiomyopathy that carries the potential to cause heart failure, arrhythmias, and embolic events within adults. The diagnosis of this cardiomyopathy can be based off a variety of echocardiographic, cardiac magnetic resonance (CMR), and computed tomography (CT) imaging criteria; none of which have been standardized to establish a firm diagnosis. This is further complicated by the observation from prior studies that LVNC may present as different forms of cardiomyopathy, each with its own subset of nuances that may change treatment strategies. Management of such cardiomyopathy has been debated in terms of anticoagulation, electrophysiologic studies to prevent arrhythmia, as well as heart failure prevention. Not enough data exists in regard to establishing firm guidelines for management. The following article aims to provide a comprehensive review in regard to the etiologies, pathogenesis, diagnostic criteria, management, and treatment of LVNC.

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References

  1. Stanton C, Bruce C, Connolly H, Brady P, Syed I, Hodge D, Asirvatham S, Friedman P (2009) Isolated left ventricular noncompaction syndrome. Am J Cardiol 104(8):1135–1138 ([PubMed: 19801037])

    Article  Google Scholar 

  2. Ritter M, Oechslin E, Sütsch G, Attenhofer C, Schneider J, Jenni R (1997) Isolated noncompaction of the myocardium in adults. Mayo Clin Proc 72(1):26–31. https://doi.org/10.4065/72.1.26

    Article  CAS  PubMed  Google Scholar 

  3. Jenni R, Oechslin EN, van der Loo B (2007) Isolated ventricular non-compaction of the myocardium in adults. Heart 93(1):11–15 ([PubMed: 16670098])

    Article  CAS  Google Scholar 

  4. Li T, Mendoza L, Chan W, McFarlane IM (2020) Non-compaction cardiomyopathy presented with atrial fibrillation, a case report and literature review. Am J Med Case Rep 8(9):281–283

    Article  Google Scholar 

  5. Aras D, Tufekcioglu O, Ergun K et al (2006) Clinical features of isolated ventricular noncompaction in adults long-term clinical course, echocardiographic properties, and predictors of left ventricular failure. J Card Fail 12(9):726–733. https://doi.org/10.1016/j.cardfail.2006.08.002

    Article  PubMed  Google Scholar 

  6. Pignatelli RH, McMahon CJ, Dreyer WJ et al (2003) Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation 108(21):2672–2678. https://doi.org/10.1161/01.CIR.0000100664.10777.B8

    Article  PubMed  Google Scholar 

  7. Kovacevic-Preradovic T, Jenni R, Oechslin EN, Noll G, Seifert B, Attenhofer Jost CH (2009) Isolated left ventricular noncompaction as a cause for heart failure and heart transplantation: a single center experience. Cardiology 112(2):158–164. https://doi.org/10.1159/000147899

    Article  CAS  PubMed  Google Scholar 

  8. Daubeney PE, Nugent AW, Chondros P, Carlin JB, Colan SD, Cheung M, Davis AM, Chow CW, Weintraub RG (2006) Clinical features and outcomes of childhood dilated cardiomyopathy: results from a national population-based study. Circulation 114:2671–2678 ([PubMed: 17116768])

    Article  Google Scholar 

  9. Nugent AW, Daubeney PE, Chondros P, Carlin JB, Colan SD, Cheung M, Davis AM, Chow CW, Weintraub RG (2005) Clinical features and outcomes of childhood hypertrophic cardiomyopathy: results from a national population-based study. Circulation 112:1332–1338 ([PubMed: 16116056])

    Article  Google Scholar 

  10. Nugent AW, Daubeney PE, Chondros P, Carlin JB, Cheung M, Wilkinson LC, Davis AM, Kahler SG, Chow CW, Wilkinson JL, Weintraub RG (2003) The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med 348:1639–1646 ([PubMed: 12711738])

    Article  Google Scholar 

  11. Ichida F (2020) Left ventricular noncompaction - Risk stratification and genetic consideration J Cardiol 75(1):1–9. https://doi.org/10.1016/j.jjcc.2019.09.011

  12. Zaragoza MV, Arbustini E, Narula J (2007) Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology. Curr Opin Pediatr 19(6):619–627. https://doi.org/10.1097/MOP.0b013e3282f1ecbc

    Article  PubMed  Google Scholar 

  13. Henderson DJ, Anderson RH (2009) The development and structure of the ventricles in the human heart. Pediatr Cardiol 30(5):588–596. https://doi.org/10.1007/s00246-009-9390-9

    Article  PubMed  Google Scholar 

  14. Garcia-Pavia P, de la Pompa JL (2015) Left ventricular noncompaction: a genetic cardiomyopathy looking for diagnostic criteria [published correction appears in J Am Coll Cardiol. Feb 10;65(5):519]. J Am Coll Cardiol 2014;64(19):1981–1983. https://doi.org/10.1016/j.jacc.2014.08.034

  15. Ackerman MJ, Priori SG, Willems S et al (2011) HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm 8(8):1308–1339. https://doi.org/10.1016/j.hrthm.2011.05.020 (PMID: 21787999)

    Article  PubMed  Google Scholar 

  16. Ichida F, Tsubata S, Bowles KR et al (2001) Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation 103(9):1256–1263. https://doi.org/10.1161/01.cir.103.9.1256

    Article  CAS  PubMed  Google Scholar 

  17. Richard P, Ader F, Roux M et al (2019) Targeted panel sequencing in adult patients with left ventricular non-compaction reveals a large genetic heterogeneity. Clin Genet 95(3):356–367. https://doi.org/10.1111/cge.13484

    Article  CAS  PubMed  Google Scholar 

  18. Ferreira C, Pierre G, Thompson R, Vernon H (2014) Barth Syndrome. In: Adam MP, Ardinger HH, Pagon RA, eds. GeneReviews®. Seattle (WA): University of Washington, Seattle

  19. Kelley-Hedgepeth A, Towbin JA, Maron MS (2009) Images in cardiovascular medicine. Overlapping phenotypes: left ventricular noncompaction and hypertrophic cardiomyopathy. Circulation. 119(23):e588-e589. https://doi.org/10.1161/CIRCULATIONAHA.108.829564

  20. Arbustini E, Narula N, Dec GW, Reddy KS et al (2013) The MOGE(S) classification for a phenotype-genotype nomenclature of cardiomyopathy: endorsed by the World Heart Federation. J Am Coll Cardiol 62(22):2046–72. https://doi.org/10.1016/j.jacc.2013.08.1644. Epub 2013 Nov 18. Erratum in: J Am Coll Cardiol. 2014 Jan 21;63(2):191–4. PMID: 24263073

  21. Bartman T, Hove J (2005) Mechanics and function in heart morphogenesis. Dev Dyn 233:373–381 ([PubMed: 15830382])

    Article  Google Scholar 

  22. Sedmera D, Pexieder T, Vuillemin M, Thompson RP, Anderson RH (2000) Developmental patterning of the myocardium. Anat Rec 258:319–337

    Article  CAS  Google Scholar 

  23. Towbin JA et al (2015) Left ventricular non-compaction cardiomyopathy. Lancet 386:813–825

    Article  Google Scholar 

  24. Quarta G, Papadakis M, Donna PD et al (2017) Grey zones in cardiomyopathies: defining boundaries between genetic and iatrogenic disease. Nat Rev Cardiol 14(2):102–112. https://doi.org/10.1038/nrcardio.2016.175

    Article  CAS  PubMed  Google Scholar 

  25. Pignatelli RH, McMahon CJ, Dreyer WJ, Denfield SW, Price J, Belmont JW et al (2003) Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation 108:2672–2678

    Article  Google Scholar 

  26. Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T et al (1999) Clinical features of isolated noncompaction of the ventricular myocardium: long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol 34:233–240

    Article  CAS  Google Scholar 

  27. Nihei K, Shinomiya N, Kabayama H et al (2004) Wolff-Parkinson-White (WPW) syndrome in isolated noncompaction of the ventricular myocardium (INVM). Circ J 68(1):82–84. https://doi.org/10.1253/circj.68.82

    Article  PubMed  Google Scholar 

  28. Udeoji DU, Philip KJ, Morrissey RP, Phan A, Schwarz ER (2013) Left ventricular noncompaction cardiomyopathy: updated review. Ther Adv Cardiovasc Dis 7(5):260–273. https://doi.org/10.1177/1753944713504639

    Article  PubMed  Google Scholar 

  29. Akhbour S, Fellat I, Fennich N et al (2015) Electrocardiographic findings in correlation to magnetic resonance imaging patterns in African patients with isolated ventricular noncompaction. Anatol J Cardiol 15(7):550–555. https://doi.org/10.5152/akd.2014.5577

    Article  PubMed  Google Scholar 

  30. Miyake CY, Kim JJ (2015) Arrhythmias in left ventricular noncompaction. Card Electrophysiol Clin 7(2):319–330. https://doi.org/10.1016/j.ccep.2015.03.007

    Article  PubMed  Google Scholar 

  31. Wengrofsky P, Armenia C, Oleszak F et al (2019) Left ventricular trabeculation and noncompaction cardiomyopathy: a review. EC Clin Exp Anat 2(6):267–283

    PubMed  PubMed Central  Google Scholar 

  32. Wang C, Takasaki A, Watanabe Ozawa S, Nakaoka H, Okabe M, Miyao N et al (2017) Long-term prognosis of patients with left ventricular noncompaction- com-parison between infantile and juvenile types. Circ J 81:694–700

    Article  Google Scholar 

  33. Jefferies JL, Wilkinson JD, Sleeper LA et al (2015) Cardiomyopathy phenotypes and outcomes for children with left ventricular myocardial noncompaction: results from the Pediatric Cardiomyopathy Registry. J Card Fail 21(11):877–884. https://doi.org/10.1016/j.cardfail.2015.06.381

    Article  PubMed  PubMed Central  Google Scholar 

  34. Brescia ST, Rossano JW, Pignatelli R, Jefferies JL, Price JF, Decker JA et al (2013) Mortality and sudden death in pediatric left ventricular noncompaction in a tertiary referral center. Circulation 127:2202–2208

    Article  Google Scholar 

  35. Bhatia NL, Tajik AJ, Wilansky S, Steidley DE, Mookadam F (2011) Isolated noncom-paction of the left ventricular myocardium in adults: a systematic overview. J Card Fail 17:771–778

    Article  Google Scholar 

  36. Maron BJ et al (2006) Contemporary definitions and classifications of the cardiomyopathies: an American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure, and Transplantation Committee; Quality of Care Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 11314:1807–1816 ([PubMed: 16567565])

    Article  Google Scholar 

  37. Zuccarino F et al (2015) Left ventricular noncompaction: imaging findings and diagnostic criteria. Am J Roentgenol 2045:W519-530 ([PubMed: 25905958])

    Article  Google Scholar 

  38. Pelliccia A, Caselli S, Sharma S et al (2018) Internal reviewers for EAPC and EACVI. European Association of Preventive Cardiology (EAPC) and European Association of Cardiovascular Imaging (EACVI) joint position statement: recommendations for the indication and interpretation of cardiovascular imaging in the evaluation of the athlete's heart. Eur Heart J 39(21):1949–1969. https://doi.org/10.1093/eurheartj/ehx532. PMID: 29029207

  39. Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R (1990) Isolated noncompaction of left ventricular myocardium. A study of eight cases Circulation 82:507–513. https://doi.org/10.1161/01.CIR.82.2.507

    Article  CAS  PubMed  Google Scholar 

  40. Stöllberger C, Finsterer J, Blazek G (2001) Isolated left ventricular abnormal trabeculation: follow-up and association with neuromuscular disorders. Can J Cardiol 17(2):163–168 (PMID: 11223486)

    PubMed  Google Scholar 

  41. Finsterer J, Stöllberger C (2012) Apical noncompaction in metabolic myopathy may be missed on echocardiography but visible on cardiac MRI or misinterpreted as apical hypokinesia. Int J Cardiol 160(2):e15–e17. https://doi.org/10.1016/j.ijcard.2011.12.024 (Epub 2012 Jan 9 PMID: 22227253)

    Article  PubMed  Google Scholar 

  42. Mavrogeni SI, Markousis-Mavrogenis G, Vartela V et al (2019) The pivotal role of cardiovascular imaging in the identification and risk stratification of non-compaction cardiomyopathy patients [published online ahead of print, 2019 Nov 30]. Heart Fail Rev. https://doi.org/10.1007/s10741-019-09898-8

  43. Joong A, Hayes DA, Anderson BR, Zuckerman WA, Carroll SJ, Lai WW (2017) Comparison of echocardiographic diagnostic criteria of left ventricular noncompaction in a pediatric population. Pediatr Cardiol 38(7):1493–1504. https://doi.org/10.1007/s00246-017-1691-9. Epub 2017 Aug 3. PMID: 28776136; PMCID: PMC5941936

  44. Saleeb SF, Margossian R, Spencer CT, Alexander ME, Smoot LB, Dorfman AL, Bergersen L, Gauvreau K, Marx GR, Colan SD (2012) Reproducibility of echocardiographic diagnosis of left ventricular noncompaction. J Am Soc Echocardiogr 25(2):194–202. https://doi.org/10.1016/j.echo.2011.10.002 (Epub 2011 Oct 28 PMID: 22036126)

    Article  PubMed  Google Scholar 

  45. Ana G. Almeida (2017) Left ventricular noncompaction, cardiomyopathies - types and treatments, Kaan Kirali, IntechOpen, https://doi.org/10.5772/66291. Available from: https://www.intechopen.com/books/cardiomyopathies-types-and-treatments/left-ventricular-noncompaction

  46. Petersen SE, Selvanayagam JB, Wiesmann F, Robson MD, Francis JM, Anderson RH, Watkins H, Neubauer S (2005) Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol 46(1):101–105. https://doi.org/10.1016/j.jacc.2005.03.045 (PMID: 15992642)

    Article  PubMed  Google Scholar 

  47. Kawel N, Nacif M, Arai AE, Gomes AS, Hundley WG, Johnson WC, Prince MR, Stacey RB, Lima JA, Bluemke DA (2012) Trabeculated (noncompacted) and compact myocardium in adults: the multi-ethnic study of atherosclerosis. Circ Cardiovasc Imaging 5(3):357–66. https://doi.org/10.1161/CIRCIMAGING.111.971713. Epub 2012 Apr 12. PMID: 22499849; PMCID: PMC3399115

  48. Jacquier A, Thuny F, Jop B, Giorgi R, Cohen F, Gaubert JY, Vidal V, Bartoli JM, Habib G, Moulin G (2010) Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction. Eur Heart J 9:1098–1104. https://doi.org/10.1093/eurheartj/ehp595 (Epub 2010 Jan 19 PMID: 20089517)

    Article  Google Scholar 

  49. Grothoff M, Pachowsky M, Hoffmann J, Posch M, Klaassen S, Lehmkuhl L, Gutberlet M (2012) Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies. Eur Radiol. 22(12):2699–709. https://doi.org/10.1007/s00330-012-2554-7. Epub 2012 Jul 10. PMID: 22772366; PMCID: PMC3486997

  50. Positano V, Meloni A, Macaione F, Santarelli MF, Pistoia L, Barison A, Novo S, Pepe A (2018) Non-compact myocardium assessment by cardiac magnetic resonance: dependence on image analysis method. Int J Cardiovasc Imaging 34(8):1227–1238. https://doi.org/10.1007/s10554-018-1331-3 (Epub 2018 Mar 9 PMID: 29524076)

    Article  PubMed  Google Scholar 

  51. Ivanov A, Dabiesingh DS, Bhumireddy GP et al (2017) Prevalence and prognostic significance of left ventricular noncompaction in patients referred for cardiac magnetic resonance imaging. Circ Cardiovasc Imaging 10(9):e006174. https://doi.org/10.1161/CIRCIMAGING.117.006174 (PMID: 28899950)

    Article  PubMed  Google Scholar 

  52. Grigoratos C, Barison A, Ivanov A, Andreini D, Amzulescu MS, Mazurkiewicz L, De Luca A, Grzybowski J, Masci PG, Marczak M, Heitner JF, Schwitter J, Gerber BL, Emdin M, Aquaro GD (2019) Meta-analysis of the prognostic role of late gadolinium enhancement and global systolic impairment in left ventricular noncompaction. JACC Cardiovasc Imaging 12(11 Pt 1):2141–2151. https://doi.org/10.1016/j.jcmg.2018.12.029 (Epub 2019 Mar 13 PMID: 30878415)

    Article  PubMed  Google Scholar 

  53. Captur G, Nihoyannopoulos P (2010) Left ventricular non-compaction: genetic heterogeneity, diagnosis and clinical course. Int J Cardiol 140(2):145–153. https://doi.org/10.1016/j.ijcard.2009.07.003 (Epub 2009 Aug 6 PMID: 19664830)

    Article  PubMed  Google Scholar 

  54. Steffel J, Duru F (2012) Rhythm disorders in isolated left ventricular noncompaction. Ann Med 44(2):101–108. https://doi.org/10.3109/07853890.2011.554427 (Epub 2011 Jun 3 PMID: 21639721)

    Article  PubMed  Google Scholar 

  55. Aras D, Tufekcioglu O, Ergun K, Ozeke O, Yildiz A, Topaloglu S, Deveci B, Sahin O, Kisacik HL, Korkmaz S (2006) Clinical features of isolated ventricular noncompaction in adults long-term clinical course, echocardiographic properties, and predictors of left ventricular failure. J Card Fail 12(9):726–733. https://doi.org/10.1016/j.cardfail.2006.08.002 (PMID: 17174235)

    Article  PubMed  Google Scholar 

  56. Frischknecht BS, Attenhofer Jost CH, Oechslin EN, Seifert B, Hoigné P, Roos M, Jenni R (2005) Validation of noncompaction criteria in dilated cardiomyopathy, and valvular and hypertensive heart disease. J Am Soc Echocardiogr 18(8):865–872. https://doi.org/10.1016/j.echo.2005.03.011 (PMID: 16084340)

    Article  PubMed  Google Scholar 

  57. Goo HW, Park IS (2007) Left ventricular noncompaction in an infant: use of non-ECG-gated cardiac CT. Pediatr Radiol 37(2):217–220. https://doi.org/10.1007/s00247-006-0360-6 (Epub 2006 Dec 14 PMID: 17171353)

    Article  PubMed  Google Scholar 

  58. Hamamichi Y, Ichida F, Hashimoto I, Uese KH, Miyawaki T, Tsukano S, Ono Y, Echigo S, Kamiya T (2001) Isolated noncompaction of the ventricular myocardium: ultrafast computed tomography and magnetic resonance imaging. Int J Cardiovasc Imaging 17(4):305–314. https://doi.org/10.1023/a:1011658926555 (PMID: 11599870)

    Article  CAS  PubMed  Google Scholar 

  59. Melendez-Ramirez G, Castillo-Castellon F, Espinola-Zavaleta N, Meave A, Kimura-Hayama ET (2012) Left ventricular noncompaction: a proposal of new diagnostic criteria by multidetector computed tomography. J Cardiovasc Comput Tomogr 6(5):346–354. https://doi.org/10.1016/j.jcct.2012.07.001 (Epub 2012 Aug 16 PMID: 22981859)

    Article  PubMed  Google Scholar 

  60. Stacey RB, Andersen MM, St Clair M et al (2013) Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc Imaging 6(9):931–940. https://doi.org/10.1016/j.jcmg.2013.01.014 (Epub 2013 Jun 13 PMID: 23769489)

    Article  PubMed  Google Scholar 

  61. Captur G, Muthurangu V, Cook C, Flett AS et al (2013) Quantification of left ventricular trabeculae using fractal analysis. J Cardiovasc Magn Reson 15(1):36. https://doi.org/10.1186/1532-429X-15-36.PMID:23663522;PMCID:PMC3680331

    Article  PubMed  PubMed Central  Google Scholar 

  62. Burke A, Mont E, Kutys R, Virmani R (2005) Left ventricular noncompaction: a pathological study of 14 cases. Hum Pathol 36(4):403–411. https://doi.org/10.1016/j.humpath.2005.02.004 (PMID: 15892002)

    Article  PubMed  Google Scholar 

  63. Arbustini E, Favalli V, Narula N, Serio A, Grasso M (2016) Left ventricular noncompaction: a distinct genetic cardiomyopathy? J Am Coll Cardiol 68(9):949–966. https://doi.org/10.1016/j.jacc.2016.05.096.Erratum.In:JAmCollCardiol.2016Oct18;68(16):1821 (PMID: 27561770)

    Article  PubMed  Google Scholar 

  64. Charron P, Arad M, Arbustini E, Basso C et al (2010) European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 31(22):2715–26. https://doi.org/10.1093/eurheartj/ehq271. Epub 2010 Sep 7. PMID: 20823110

  65. Hoedemaekers YM et al “The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaciton cardriomyopathy”. Circulation: Cardiovascular Genetics 33 (2010): 232–239. [PubMed: 20530761]

  66. Towbin JA, Jefferies JL (2017) Cardiomyopathies due to left ventricular noncompaction, mitochondrial and storage diseases, and inborn errors of metabolism. Circ Res 121:838–854. [PubMed: 28912186]

  67. Yancy CW, Jessup M, Bozkurt B et al (2017) ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation 136(6):e137–e161. https://doi.org/10.1161/CIR.0000000000000509 (Epub 2017 Apr 28 PMID: 28455343)

    Article  PubMed  Google Scholar 

  68. Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T, Hamada H, Hirose O, Isobe T, Yamada K, Kurotobi S, Mito H, Miyake T, Murakami Y, Nishi T, Shinohara M, Seguchi M, Tashiro S, Tomimatsu H (1999) Clinical features of isolated noncompaction of the ventricular myocardium: long-term clinical course, hemodynamic properties, and genetic background. J Am Coll Cardiol 34(1):233–240. https://doi.org/10.1016/s0735-1097(99)00170-9 (PMID: 10400016)

    Article  CAS  PubMed  Google Scholar 

  69. Cevik C, Shah N, Wilson JM, Stainback RF (2012) Multiple left ventricular thrombi in a patient with left ventricular noncompaction. Tex Heart Inst J 39(4):550–3. PMID: 22949776; PMCID: PMC3423290

  70. Stöllberger C, Blazek G, Dobias C, Hanafin A, Wegner C, Finsterer J (2011) Frequency of stroke and embolism in left ventricular hypertrabeculation/noncompaction. Am J Cardiol 108(7):1021–1023. https://doi.org/10.1016/j.amjcard.2011.05.039 (Epub 2011 Jul 23 PMID: 21784395)

    Article  PubMed  Google Scholar 

  71. Oechslin E, Jenni R (2011) Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? Eur Heart J 32(12):1446–1456. https://doi.org/10.1093/eurheartj/ehq508 (Epub 2011 Jan 31 PMID: 21285074)

    Article  PubMed  Google Scholar 

  72. Abdelnaby M, Almaghraby A, Abdelkarim O et al (2019) The role of rivaroxaban in left ventricular thrombi. Anatol J Cardiol 21(1):47–50. https://doi.org/10.14744/AnatolJCardiol.2018.48313.PMID:30587707;PMCID:PMC6382905

    Article  PubMed  PubMed Central  Google Scholar 

  73. Abdelnabi M, Saleh Y, Fareed A et al (2021) Comparative study of oral anticoagulation in left ventricular thrombi (No-LVT Trial). J Am Coll Cardiol 77(12):1590–1592. https://doi.org/10.1016/j.jacc.2021.01.049 (PMID: 33766266)

    Article  PubMed  Google Scholar 

  74. Al-Abcha A, Herzallah K, Saleh Y et al (2020) The role of direct oral anticoagulants versus vitamin K antagonists in the treatment of left ventricular thrombi: a meta-analysis and systematic review. Am J Cardiovasc Drugs https://doi.org/10.1007/s40256-020-00458-2. Epub ahead of print. PMID: 33354748

  75. Bennett CE, Freudenberger R (2016) The current approach to diagnosis and management of left ventricular noncompaction cardiomyopathy: review of the literature. Cardiol Res Pract 2016:5172308. https://doi.org/10.1155/2016/5172308. Epub. PMID: 26881173; PMCID: PMC4737020

  76. Derval N, Jais P, O'Neill MD, Haissaguerre M (2008) Apparent idiopathic ventricular tachycardia associated with isolated ventricular noncompaction. Heart Rhythm. 2009 Mar;6(3):385–8. https://doi.org/10.1016/j.hrthm.2008.11.020. Epub. PMID: 19251216

  77. Bertini M, Ziacchi M, Biffi M, Biagini E, Rocchi G, Martignani C, Ferlito M, Pasquale F, Cervi E, Branzi A, Rapezzi C, Boriani G (2011) Effects of cardiac resynchronisation therapy on dilated cardiomyopathy with isolated ventricular non-compaction. Heart 97(4):295–300. https://doi.org/10.1136/hrt.2010.211607 (Epub 2010 Dec 16 PMID: 21163889)

    Article  PubMed  Google Scholar 

  78. Oginosawa Y, Nogami A, Soejima K, Aonuma K, Kubota S, Sato T, Sugiyasu A, Yoshida K, Kowase S, Sakamaki M, Kurosaki K, Kato K (2008) Effect of cardiac resynchronization therapy in isolated ventricular noncompaction in adults: follow-up of four cases. J Cardiovasc Electrophysiol 19(9):935–8. https://doi.org/10.1111/j.1540-8167.2008.01161.x. Epub. PMID: 18399967

  79. Qiu Q, Chen YX, Mai JT, Yuan WL, Wei YL, Liu YM, Yang L, Wang JF (2014) Effects of cardiac resynchronization therapy on left ventricular remodeling and dyssynchrony in patients with left ventricular noncompaction and heart failure. Int J Cardiovasc Imaging 2015 Feb;31(2):329–37. https://doi.org/10.1111/j.1540-8167.2008.01161.x. Epub. PMID: 18399967

  80. Wu M (2018) Mechanisms of trabecular formation and specification during cardiogenesis. Pediatr Cardiol 39(6):1082–1089. https://doi.org/10.1007/s00246-018-1868-x

    Article  PubMed  PubMed Central  Google Scholar 

  81. Al-kindi S, El-Amm C, Ginwalla M, Hoit B, Park S, Oliveira G (2014) Heart transplant outcomes in patients with left ventricular non-compaction cardiomyopathy. J Heart Lung Transplant 34(6):761–765 ([PubMed: 25572453])

    Article  Google Scholar 

  82. Lakdawala N (2015) Big data for a rare disease: examining heart transplantation for left ventricular noncompaction in the United Network of Organ Sharing registry. J Heart Lung Transplant 34(6):759–760 ([PubMed: 25940078])

    Article  Google Scholar 

  83. van Waning JI, Caliskan K, Hoedemaekers YM et al (2018) Genetics, clinical features, and long-term outcome of noncompaction cardiomyopathy. J Am Coll Cardiol 71(7):711–722. https://doi.org/10.1016/j.jacc.2017.12.019 (PMID: 29447731)

    Article  PubMed  Google Scholar 

  84. Wang H, Chu YQ, Yu XY et al (2020) Correlation between arrhythmia and the prognosis in children with EFE/LVNC/DCM. Front Pediatr 8:280. https://doi.org/10.3389/fped.2020.00280.PMID:32587842;PMCID:PMC7297920

    Article  PubMed  PubMed Central  Google Scholar 

  85. Zemrak F, Ahlman MA, Captur G et al (2014) The relationship of left ventricular trabeculation to ventricular function and structure over a 9.5-year follow-up: the MESA study. J Am Coll Cardiol 64(19):1971–80. https://doi.org/10.1016/j.jacc.2014.08.035. Epub. PMID: 25440091; PMCID: PMC4610345

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Authors and Affiliations

  1. Department of Internal Medicine, Michigan State University, East Lansing, USA

    Shaurya Srivastava, Majid Yavari, Abdullah Al-abcha & George Abela

  2. Sparrow Hospital, Transthoracic Cardiovascular Institute, Lansing, USA

    Sandeep Banga

Authors
  1. Shaurya Srivastava
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  2. Majid Yavari
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  3. Abdullah Al-abcha
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  4. Sandeep Banga
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  5. George Abela
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Contributions

Shaurya Srivastava—conducted research regarding the findings of each article, wrote the manuscript, reviewed and helped edit the manuscript. Majid Yavari—helped with creation of visuals (tables and figure), reviewed and helped edit manuscript. Abdullah Al Abcha—helped edit and review each section of the article. Sandeep Banga—had the initial idea for this review, helped conduct research regarding each article, helped to edit and review each section. George Abela—cardiology attending, helped review the article.

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Correspondence to Shaurya Srivastava.

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Srivastava, S., Yavari, M., Al-abcha, A. et al. Ventricular non-compaction review. Heart Fail Rev 27, 1063–1076 (2022). https://doi.org/10.1007/s10741-021-10128-3

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