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Circular RNAs as potential theranostics in the cardiac fibrosis

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Abstract

Circular RNAs (circRNAs) are a type of single-stranded RNA molecules that normally do not encode proteins. circRNAs are involved in many physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized as a pathological force in advanced heart diseases. A growing number of studies have reported that the occurrence and development of cardiac fibrosis is closely associated with the regulation of circRNAs. This review summarizes the current understanding of circRNA biogenesis and function and will highlight the recent updates regarding the involvement of circRNAs in cardiac fibrosis, and their potential as emerging biomarkers and therapeutic targets.

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  1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box 14115-154, Tehran, Iran

    Fatemeh Yousefi & Bahram M. Soltani

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  1. Fatemeh Yousefi
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  2. Bahram M. Soltani
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Correspondence to Bahram M. Soltani.

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Yousefi, F., Soltani, B.M. Circular RNAs as potential theranostics in the cardiac fibrosis. Heart Fail Rev 26, 195–203 (2021). https://doi.org/10.1007/s10741-019-09908-9

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