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Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection

  • Genetic Epidemiology
  • Published:
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Abstract

Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections. In a case-control setting, we investigated the association of MBL2 functional polymorphisms with Human Papillomas Virus (HPV) infection. No differences between cases (HPV+) and controls (HPV−) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV− groups.

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Abbreviations

MBL2:

Mannose-Binding Lectin 2

MBP:

Mannose-Binding Protein

HPV:

Human Papillomas Virus

CIN:

Cervical Intraepithelial Neoplasia

RFLP:

Restriction Fragment Length Polymorphisms

SNP:

Single Nucleotide Polymorphism

GLM:

General Regression Model

HW:

Hardy-Weinberg

HIV:

Human Immunodeficiency Virus

HBV:

human Hepatitis B Virus

HCV:

Human Hepatitis C Virus

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Acknowledgements

This study was partly supported by grants from “Ministero della Salute” IRCCS Research Program, Ricerca Corrente 2006–2008, Linea n. 4 “Tumori” and Linea n. 2 “Malattie di Rilevanza Sociale”

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Authors and Affiliations

  1. Laboratory of Oncology, Department of Research, IRCCS “Casa Sollievo della Sofferenza”, Viale Padre Pio, San Giovanni Rotondo, FG, I-71013, Italy

    Paola Parrella, Antonietta P. Gallo, Maria Prencipe & Vito M. Fazio

  2. Laboratory of Gerontology & Geriatrics, Department of Research, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, FG, Italy

    Davide Seripa, Maria G. Matera & Carolina Gravina

  3. Institute of Neurobiology and Molecular Medicine, CNR-ARTOV, Rome, Italy

    Monica Rinaldi & Emanuela Signori

  4. Laboratory of Molecular Medicine and Biotechnology, Campus Bio-Medico University School of Medicine, Rome, Italy

    Emanuela Signori & Vito M. Fazio

  5. Laboratory of Atherosclerosis and Thrombosis, Department of Research, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, FG, Italy

    Elvira Grandone

  6. Department of Ginecology-Oncology, “Regina Elena” National Cancer Institute, Rome, Italy

    Luciano Mariani

  7. Laboratory of Clinical Pathology, “San Gallicano” Dermatology Institute, Rome, Italy

    Paola Cordiali

  8. IRCCS IFO, “San Gallicano” Dermatology Institute, Rome, Italy

    Aldo Di Carlo

  9. II Clinic of Obstetrics and Gynecology, University “La Sapienza”, Rome, Italy

    Patrizia Stentella & Antonio Pachì

Authors
  1. Paola Parrella
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  2. Davide Seripa
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  3. Maria G. Matera
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  4. Monica Rinaldi
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  5. Emanuela Signori
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  6. Carolina Gravina
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  7. Antonietta P. Gallo
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  8. Maria Prencipe
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  9. Elvira Grandone
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  10. Luciano Mariani
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  11. Paola Cordiali
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  12. Aldo Di Carlo
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  13. Patrizia Stentella
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  14. Antonio Pachì
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  15. Vito M. Fazio
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Corresponding author

Correspondence to Paola Parrella.

Additional information

Paola Parrella and Davide Seripa contribute equally to this work.

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Parrella, P., Seripa, D., Matera, M.G. et al. Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection. Eur J Epidemiol 22, 159–162 (2007). https://doi.org/10.1007/s10654-007-9111-8

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  • DOI: https://doi.org/10.1007/s10654-007-9111-8

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