Abstract
Primary prevention is a key strategy to reducing the global burden of cancer, a disease responsible for ~ 9.6 million deaths per year and predicted to top 13 million by 2030. The role of environmental geochemistry in the aetiology of many cancers—as well as other non-communicable diseases—should not be understated, particularly in low- and middle-income countries where 70% of global cancer deaths occur and reliance on local geochemistry for drinking water and subsistence crops is still widespread. This article is an expansion of a series of presentations and discussions held at the 34th International Conference of the Society for Environmental Geochemistry and Health in Livingstone, Zambia, on the value of effective collaborations between environmental geochemists and cancer epidemiologists. Key technical aspects of each field are presented, in addition to a case study of the extraordinarily high incidence rates of oesophageal cancer in the East African Rift Valley, which may have a geochemical contribution. The potential merit of veterinary studies for investigating common geochemical risk factors between human and animal disease is also highlighted.
Similar content being viewed by others
References
Aderibigbe, A. D., Stewart, A. G., & Hursthouse, A. S. (2018). Seeking evidence of multidisciplinarity in environmental geochemistry and health: An analysis of arsenic in drinking water research. Environmental Geochemistry and Health,40, 395–413.
Al-Rmalli, S. W., Jenkins, R. O., Watts, M. J., & Haris, P. I. (2010). Risk of human exposure to arsenic and other toxic elements from geophagy: Trace element analysis of baked clay using inductively coupled plasma mass spectrometry. Environmental Health,9, 79.
Ames, B. N., & Wakimoto, P. (2002). Are vitamin and mineral deficiencies a major cancer risk? Nature Reviews Cancer,2, 694–704.
Armstrong, R. W. (1972). Is there a particular kind of soil or geologic environment that predisposes to cancer? Annals of the New York Academy of Sciences,199, 239–248.
Arnold, M., Soerjomataram, I., Ferlay, J., & Forman, D. (2015). Global incidence of oesophageal cancer by histological subtype in 2012. Gut,64, 387.
Arthur, J. R., McKenzie, R. C., & Beckett, G. J. (2003). Selenium in the immune system. The Journal of nutrition,133, 1457S–1459S.
Ayaya, S. O., & Esamai, F. O. (2001). Health problems of street children in Eldoret, Kenya. East African medical journal,78, 624–630.
Bertone, E. R., Snyder, L. A., & Moore, A. S. (2002). Environmental tobacco smoke and risk of malignant lymphoma in pet cats. American Journal of Epidemiology,156, 268–273.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A cancer journal for clinicians,68(6), 394–424.
Davey, G., Tekola, F., & Newport, M. J. (2007). Podoconiosis: Non-infectious geochemical elephantiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene,101, 1175–1180.
Davies, T. C. (2008). Environmental health impacts of East African Rift volcanism. Environmental Geochemistry and Health,30, 325–338.
Espina, C., Herrero, R., Sankaranarayanan, R., Krug, E., Wild, C. P., & Schüz, J. (2018). Toward the World code against cancer. Journal of Global Oncology,4, 1–8.
Espina, C., Porta, M., Schüz, J., Aguado, I. H., Percival, R. V., Dora, C., et al. (2013). Environmental and occupational interventions for primary prevention of cancer: A cross-sectorial policy framework. Environmental Health Perspectives,121, 420–426.
Francesconi, K. A., & Kuehnelt, D. (2004). Determination of arsenic species: A critical review of methods and applications, 2000–2003. Analyst,129, 373–395.
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., et al. (2004). A census of human cancer genes. Nature Reviews Cancer,4, 177.
Hanahan, D., & Weinberg, R. A. (2000). The hallmarks of cancer. Cell,100, 57–70.
Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell,144, 646–674.
Hayes, H. M., Tarone, R. E., Casey, H. W., & Huxsoll, D. L. (1990). Excess of seminomas observed in Vietnam service US military working dogs. JNCI: Journal of the National Cancer Institute,82, 1042–1046.
Ho, E. (2004). Zinc deficiency, DNA damage and cancer risk. The Journal of nutritional biochemistry,15, 572–578.
Hurst, R., Siyame, E. W., Young, S. D., Chilimba, A. D., Joy, E. J., Black, C. R., et al. (2013). Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi. Scientific Reports,3, 1425.
IARC (2006). Preamble to the IARC Monographs, International Agency for Research on Cancer. available: https://monographs.iarc.fr/wp-content/uploads/2018/06/CurrentPreamble.pdf. Accessed 19/07/2018.
Joy, E. J. M., Ander, E. L., Young, S. D., Black, C. R., Watts, M. J., Chilimba, A. D. C., et al. (2014). Dietary mineral supplies in Africa. Physiologia Plantarum,151, 208–229.
Joy, E. J. M., Broadley, M. R., Young, S. D., Black, C. R., Chilimba, A. D. C., Ander, E. L., et al. (2015). Soil type influences crop mineral composition in Malawi. Science of the Total Environment,505, 587–595.
Kamangar, F., Chow, W. H., Abnet, C. C., & Dawsey, S. M. (2009). Environmental causes of esophageal cancer. Gastroenterology Clinics of North America,38, 27–57.
Kelsey, J. L., Moore, A. S., & Glickman, T. (1998). Epidemiologic studies of risk factors for cancer in pet dogs. Epidemiologic Reviews,20, 204–217.
Lark, R. M., Ander, E. L., Cave, M. R., Knights, K. V., Glennon, M. M., & Scanlon, R. P. (2014). Mapping trace element deficiency by cokriging from regional geochemical soil data: A case study on cobalt for grazing sheep in Ireland. Geoderma,226, 64–78.
Mao, L., Bailey, E. H., Chester, J., Joseph Dean, E., Ander, L., Chenery, S. R., et al. (2014). Lability of Pb in soil: Effects of soil properties and contaminant source. Environmental Chemistry,11, 690–701.
McCormack, V. A., Menya, D., Munishi, M. O., Dzamalala, C., Gasmelseed, N., Leon Roux, M., et al. (2016). Informing etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting-specific exposures to known and putative risk factors. International journal of cancer,140(2), 259–271.
McCormack, V. A., & Schüz, J. (2012). Africa’s growing cancer burden: Environmental and occupational contributions. Cancer Epidemiology,36, 1–7.
McGlashan, N. D. (1969). Oesophageal cancer and alcoholic spirits in central Africa. Gut,10, 643–650.
McKinley, J. M., Ofterdinger, U., Young, Ml, Barsby, A., & Gavin, A. (2013). Investigating local relationships between trace elements in soils and cancer data. Spatial statistics,5, 25–41.
Middleton, D. R. S., Watts, M. J., Beriro, D. J., Hamilton, E. M., Leonardi, G. S., Fletcher, T., et al. (2017). Arsenic in residential soil and household dust in Cornwall, South West England: Potential human exposure and the influence of historical mining. Environmental Science: Processes & impacts,19, 517–527.
Middleton, D. R. S., Watts, M. J., Hamilton, E. M., Ander, E. L., Close, R. M., Exley, K. S., et al. (2016). Urinary arsenic profiles reveal exposures to inorganic arsenic from private drinking water supplies in Cornwall, UK. Scientific reports,6, 25656.
Ockerse, T. (1953). Chronic endemic dental fluorosis in Kenya, East Africa. Brit. Dent. J.,95, 57–60.
Olsson, A. C., Yiwen, X., Schüz, J., Vlaanderen, J., Kromhout, H., Vermeulen, R., et al. (2013). Lung cancer risk among hairdressers: A pooled analysis of case-control studies conducted between 1985 and 2010. American Journal of Epidemiology,178, 1355–1365.
Parkin, D. M., & Khlat, M. (1996). Studies of cancer in migrants: Rationale and methodology. European Journal of Cancer,32, 761–771.
Plowright, W., Linsell, C. A., & Peers, F. G. (1971). Focus of Rumenal Cancer in Kenyan Cattle. British Journal of Cancer,25, 72.
Polya, D. A., & Middleton, D. R. S. (2017). Arsenic in drinking water: Sources & human exposure routes. In P. Bhattacharya, D. A. Polya, & D. Jovanovic (Eds.), Best practice guide on the control of arsenic in drinking water. Lyon: IWA Publishing.
Qiao, Y. L., Dawsey, S. M., Kamangar, F., Fan, J. H., Abnet, C. C., Sun, X. D., et al. (2009). Total and cancer mortality after supplementation with vitamins and minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial. Journal of the National Cancer Institute,101, 507–518.
Rink, Lothar. (2000). Zinc and the immune system. Proceedings of the Nutrition Society,59, 541–552.
Rubio, C. A., & Liu, Fu-Sheng. (1989). Spontaneous squamous carcinoma of the esophagus in chickens. Cancer,64, 2511–2514.
Schaafsma, T., Wakefield, J., Hanisch, R., Bray, F., Schuz, J., Joy, E. J., et al. (2015). Africa’s Oesophageal Cancer Corridor: Geographic variations in incidence correlate with certain micronutrient deficiencies. One: PLoS.
Schneider, R., Dorn, C. R., & Taylor, D. O. N. (1969). Factors influencing canine mammary cancer development and postsurgical survival. Journal of the National Cancer Institute,43, 1249–1261.
Schonfeld, S. J., Winde, F., Albrecht, C., Kielkowski, D., Liefferink, M., Patel, M., et al. (2014). Health effects in populations living around the uraniferous gold mine tailings in South Africa: Gaps and opportunities for research. Cancer Epidemiology,38, 628.
Schüz, J., Espina, C., Villain, P., Herrero, R., Leon, M. E., Minozzi, S., et al. (2015). European Code against Cancer 4th Edition: 12 ways to reduce your cancer risk. Cancer Epidemiology,39, S1–S10.
Smith, M. T., Guyton, K. Z., Gibbons, C. F., Fritz, J. M., Portier, C. J., Rusyn, I., et al. (2016). Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environmental Health Perspectives,124, 713.
Smith, A. H., Hopenhayn-Rich, C., Bates, M. N., Goeden, H. M., Hertz-Picciotto, I., Duggan, H. M., et al. (1992). Cancer risks from arsenic in drinking water. Environmental Health Perspectives,97, 259.
Smith, A. H., Lingas, E. O., & Rahman, M. (2000). Contamination of drinking-water by arsenic in Bangladesh: A public health emergency. Bulletin of the World Health Organization,78, 1093–1103.
Steevens, J., van den Brandt, P. A., Goldbohm, R. A., & Schouten, L. J. (2010). Selenium status and the risk of esophageal and gastric cancer subtypes: The Netherlands cohort study. Gastroenterology,138, 1704–1713.
Stewart, B. W., & Wild, C. P. (2014). World Cancer Report 2014. Lyon: International Agency for Research on Cancer.
Sylla, B. S., & Wild, C. P. (2012). A million africans a year dying from cancer by 2030: What can cancer research and control offer to the continent? International Journal of Cancer,130, 245–250.
Tapiero, H., Townsend, D. M., & Tew, K. D. (2003). The antioxidant role of selenium and seleno-compounds. Biomedicine & Pharmacotherapy,57, 134–144.
Thornton, I. (1993). Environmental geochemistry and health in the 1990s: A global perspective. Applied Geochemistry,8, 203–210.
Thornton, I. (2002). Geochemistry and the mineral nutrition of agricultural livestock and wildlife. Applied Geochemistry,17, 1017–1028.
Thornton, I., & Webb, J. S. (1979). Geochemistry and health in the United Kingdom. Philosophical Transactions of the Royal Society of London. B, Biological Sciences,288, 151–168.
Tomasetti, C., & Vogelstein, B. (2015). Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science,347, 78–81.
Vineis, P., & Wild, C. P. (2014). Global cancer patterns: Causes and prevention. The Lancet,383, 549–557.
Vint, F. W. (1935). Malignant Disease in the Natives of Kenya. Lancet,226, 628–630.
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., Jr., & Kinzler, K. W. (2013). Cancer genome landscapes. Science,339, 1546–1558.
Watts, M. J., Joy, E. J. M., Young, S. D., Broadley, M. R., Chilimba, A. D. C., Gibson, R. S., et al. (2015). Iodine source apportionment in the Malawian diet. Scientific reports,5, 15251.
WHO. (2013). International classification of diseases for oncology (ICD-O)–3rd edition, 1st revision. Geneva: World Health Organization.
WHO (2018). Fact sheets on cancer, updated 1 February 2018, available: http://www.who.int/en/news-room/fact-sheets/detail/cancer. Accessed 19/07/2018.
WHO/UNICEF. (2017). ‘Progress on drinking water, sanitation and hygiene: 2017 update and SDG baselines. Geneva: World Health Organization.
Wild, C., Brennan, P., Plummer, M., Bray, F., Straif, K., & Zavadil, J. (2015). Cancer risk: Role of chance overstated. Science,347, 728.
World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) (2017). Licence: CC BY-NC-SA 3.0 IGO.
Woywodt, A., & Kiss, A. (2002). Geophagia: The history of earth-eating. Journal of the Royal Society of Medicine,95, 143–146.
Wu, S., Powers, S., Zhu, W., & Hannun, Y. A. (2016). Substantial contribution of extrinsic risk factors to cancer development. Nature,529, 43.
Acknowledgements
The authors are grateful to the organisers and delegates of the 34th SEGH International Conference, where this article was conceived and to the Environment, Sustainability and Environment Division of the Royal Society of Chemistry (RSC), which awarded funds to partially cover D. Middleton’s conference attendance. The work was undertaken during an IARC postdoctoral fellowship (D. Middleton) partially supported by the European Commission FP7 Marie Curie Actions —People—Co-funding of regional, national and international programs (COFUND).
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Middleton, D.R.S., McCormack, V.A., Watts, M.J. et al. Environmental geochemistry and cancer: a pertinent global health problem requiring interdisciplinary collaboration. Environ Geochem Health 42, 1047–1056 (2020). https://doi.org/10.1007/s10653-019-00303-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10653-019-00303-9