Abstract
Healthy aging is considered as the core issue of aging population. Centenarians are a symbol of healthy aging. Concentration of elements in hair is an indicator of micronutrient status, which can affect the human health. In the present study, we investigated element concentrations in the scalp hair of 255 healthy centenarians from Hainan Island, China. The pattern of intergenerational transmission of elements and the effects of confounders such as sex, age, education level, smoking habits, alcohol intake, and frequency of hospitalization on hair element concentrations were assessed. For most elements, the load in hair increased significantly through intergenerational transmission (i.e., centenarians < children < grandchildren). Our results also demonstrated that female centenarians had significantly higher concentrations of Ca, Mg, Mn, Se, and Sr but lower levels of Cr and P. The Mn level was statistically significantly lower in the primary studies group. Alcohol intake was positively associated with Cd and Na levels, whereas smoking habits showed no significant effect on all the elements. Furthermore, the frequency of hospitalization was significantly positively associated with Cd, Cu, and Pb concentration. Moreover, our analysis suggested that adequate concentrations of Fe and Se might increase the life span of centenarians, whereas excessive concentrations of P and Pb were harmful to health and reduced life span. These results imply that element concentrations could be manipulated as a therapeutic modality in geriatric disease. They might also provide reference values for diseased subjects, allowing improved diagnoses and more effective therapies, which might support effective policies on health and aging.
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Aguilera, I., Daponte, A., Gil, F., Hernandez, A. F., Godoy, P., Pla, A., et al. (2008). Biomonitoring of urinary metals in a population living in the vicinity of industrial sources: A comparison with the general population of Andalusia, Spain. Science of the Total Environment, 407, 669–678.
Ahluwalia, N., Gordon, M. A., Handte, G., Mahlon, M., Li, N. Q., Beard, J. L., et al. (2000). Iron status and stores decline with age in Lewis rats. Journal of Nutrition, 130, 2378–2383.
Andersen, S. L., Sebastiani, P., Dworkis, D. A., Feldman, L., & Perls, T. T. (2012). Health span approximates life span among many supercentenarians: Compression of morbidity at the approximate limit of life span. Journals of Gerontology Series a-Biological Sciences and Medical Sciences, 67, 395–405.
Andersen-Ranberg, K., Vasegaard, L., & Jeune, B. (2001). Dementia is not inevitable: A population-based study of Danish centenarians. Journals of Gerontology Series B-Psychological Sciences and Social Sciences, 56, 152–159.
Beard, J., Biggs, S., Bloom, D. E., Fried, L. P., Hogan, P. R., Kalache, A., et al. (2011). Global population ageing: Peril or promise?Geneva: World Economic Forum.
Block, G. A., Hulbert-Shearon, T. E., Levin, N. W., & Port, F. K. (1998). Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. American Journal of Kidney Diseases, 31, 607–617.
Brulle, R. J., & Pellow, D. N. (2006). Environmental justice: Human health and environmental inequalities. Annual Review of Public Health, 27, 103–124.
Calvo, M. S., Moshfegh, A. J., & Tucker, K. L. (2014). Assessing the health impact of phosphorus in the food supply: Issues and considerations. Advances in Nutrition, 5, 104–113.
China NBS—National Bureau of Statistics of China. (2001). The fifth national population census of the People’s Republic of China.
China NBS—National Bureau of Statistics of China. (2011). The sixth national population census of the People’s Republic of China.
Christensen, K., & Vaupel, J. W. (1996). Determinants of longevity: Genetic, environmental and medical. Journal of Internal Medicine, 240, 333–341.
Darviri, C., Demakakos, P., & Charizani, F. (2008). Assessment of the health status of Greek centenarians. Archives of Gerontology and Geriatrics, 46, 67–78.
Evert, J., Lawler, E., Bogan, H., & Perls, T. (2003). Morbidity profiles of centenarians: Survivors, delayers, and escapers. Journals of Gerontology Series a-Biological Sciences and Medical Sciences, 58, 232–237.
Franchini, M., & Mannucci, P. M. (2007). Short-term effects of air pollution on cardiovascular diseases: Outcomes and mechanisms. Journal of Thrombosis and Haemostasis, 5, 2169–2174.
Ginter, E., & Simko, V. (2013). Women live longer than men. Bratislava Medical Journal-Bratislavske Lekarske Listy, 114, 45–49.
Goulle, J. P., Mahieu, L., Castermant, J., Neveu, N., Bonneau, L., Laine, G., et al. (2005). Metal and metalloid multi-elementary ICP-MS validation in whole blood, plasma, urine and hair—Reference values. Forensic Science International, 153, 39–44.
Hamilton, I. M. J., Gilmore, W. S., & Strain, J. J. (2000). Marginal copper deficiency and atherosclerosis. Biological Trace Element Research, 78, 179–189.
Hoffmann, K., Becker, K., Friedrich, C., Helm, D., Krause, C., & Seifert, B. (2000). The German Environmental Survey 1990/1992 (GerES II): Cadmium in blood, urine and hair of adults and children. Journal of Exposure Analysis and Environmental Epidemiology, 10, 126–135.
Iannotti, L. L., Tielsch, J. M., Black, M. M., & Black, R. E. (2006). Iron supplementation in early childhood: Health benefits and risks. American Journal of Clinical Nutrition, 84, 1261–1276.
Jiang, W., Hou, Q. Y., Yang, Z. F., Yu, T., Zhong, C., Yang, Y., et al. (2014). Annual input fluxes of heavy metals in agricultural soil of Hainan island, China. Environmental Science and Pollution Research, 21, 7876–7885.
Kazi, T. G., Afridi, H. I., Kazi, N., Jamali, M. K., Arain, M. B., Jalbani, N., et al. (2008). Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biological Trace Element Research, 122, 1–18.
Kestenbaum, B., Sampson, J. N., Rudser, K. D., Patterson, D. J., Seliger, S. L., Young, B., et al. (2005). Serum phosphate levels and mortality risk among people with chronic kidney disease. Journal of the American Society of Nephrology, 16, 520–528.
Li, Y. H., Yang, L. S., Wang, W. Y., Li, H. R., Lv, J. M., & Zou, X. Y. (2011). Trace element concentrations in hair of healthy Chinese centenarians. Science of the Total Environment, 409, 1385–1390.
Li, Y. H., Zou, X. Y., Lv, J. M., Yang, L. S., Li, H. R., & Wang, W. Y. (2012). Trace elements in fingernails of healthy Chinese centenarians. Biological Trace Element Research, 145, 158–165.
Luy, M., & Gast, K. (2014). Do women live longer or do men die earlier? Reflections on the causes of sex differences in fife expectancy. Gerontology, 60, 143–153.
Mertz, W. (1997). Confirmation: Chromium levels in serum, hair, and sweat decline with age. Nutrition Reviews, 55, 373–375.
Mikulewicz, M., Chojnacka, K., Gedrange, T., & Gorecki, H. (2013). Reference values of elements in human hair: A systematic review. Environmental Toxicology and Pharmacology, 36, 1077–1086.
Motta, M., Bennati, E., Ferlito, L., Malaguarnera, M., Motta, L., & IMUSCE. (2005). Successful aging in centenarians: Myths and reality. Archives of Gerontology and Geriatrics, 40, 241–251.
Olsson, I. M., Bensryd, I., Lundh, T., Ottosson, H., Skerfving, S., & Oskarsson, A. (2002). Cadmium in blood and urine—Impact of sex, age, dietary intake, iron status, and former smoking—Association of renal effects. Environmental Health Perspectives, 110, 1185–1190.
Ozaki, A., Uchiyama, M., Tagaya, H., Ohida, T., & Ogihara, R. (2007). The Japanese centenarian study: Autonomy was associated with health practices as well as physical status. Journal of the American Geriatrics Society, 55, 95–101.
Papp, L. V., Lu, J., Holmgren, A., & Khanna, K. K. (2007). From selenium to selenoproteins: Synthesis, identity, and their role in human health. Antioxidants & Redox Signaling, 9, 775–806.
Perls, T., Levenson, R., Regan, M., & Puca, A. (2002). What does it take to live to 100? Mechanisms of Ageing and Development, 123, 231–242.
Pike, J., & Chandra, R. K. (1995). Effect of vitamin and trace-element supplementation on immune indexes in healthy elderly. International Journal for Vitamin and Nutrition Research, 65, 117–121.
Poulsen, O. M., Holst, E., & Christensen, J. M. (1997). Calculation and application of coverage intervals for biological reference values—Technical report. Pure and Applied Chemistry, 69, 1601–1611.
Preziosi, P., Hercberg, S., Galan, P., Devanlay, M., Cherouvrier, F., & Dupin, H. (1994). Iron status of a healthy French population: Factors determining biochemical markers. Annals of Nutrition & Metabolism, 38, 192–202.
Robine, J. M., & Paccaud, F. (2005). Nonagenarians and centenarians in Switzerland, 1860 2001: A demographic analysis. Journal of Epidemiology and Community Health, 59, 31–37.
Salive, M. E., Cornoni-Huntley, J., Guralnick, J. M., Phillips, C. L., Wallace, R. B., Ostfeld, A. M., et al. (1992). Anemia and hemoglobin levels in older persons: Relationship with age, gender and health status. Journal of the American Geriatrics Society, 40, 489–496.
Savarino, L., Granchi, D., Ciapetti, G., Cenni, E., Ravaglia, G., Forti, P., et al. (2001). Serum concentrations of zinc and selenium in elderly people: Results in healthy nonagenarians/centenarians. Experimental Gerontology, 36, 327–339.
Schmidt, K. (1991). Vitamins, minerals, and trace-element in elderly people. Zentralblatt für Hygiene und Umweltmedizin, 191(2–3), 327–332.
Selim, A. J., Fincke, G., Berlowitz, D. R., Miller, D. R., Qian, S. X., Lee, A., et al. (2005). Comprehensive health status assessment of centenarians: Results from the 1999 large health survey of veteran enrollees. Journals of Gerontology Series a-Biological Sciences and Medical Sciences, 60, 515–519.
Slinin, Y., Foley, R. N., & Collins, A. J. (2005). Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: The USRDS waves 1, 3, and 4 study. Journal of the American Society of Nephrology, 16, 1788–1793.
Stathakos, D., Pratsinis, H., Zachos, L., Vlahaki, I., Gianakopoulou, A., Zianni, D., et al. (2005). Greek centenarians: Assessment of functional health status and life-style characteristics. Experimental Gerontology, 40, 512–518.
Steinmaus, C. M., Nunez, S., & Smith, A. H. (2000). Diet and bladder cancer: A meta-analysis of six dietary variables. American Journal of Epidemiology, 151, 693–702.
Suleiman, J. S., Hu, B., Pu, X. L., Huang, C. Z., & Jiang, Z. C. (2007). Nanometer-sized zirconium dioxide microcolumn separation/preconcentration of trace metals and their determination by ICP-OES in environmental and biological samples. Microchimica Acta, 159, 379–385.
UN DESA (United Nations, Department of Economic and Social Affairs), Population Division. (2013). World population prospects: The 2012 revision, key findings and advance tables. Working Paper No. ESA/P/WP.227.
US EPA (United States Environmental Protection Agency). (1979).Toxic trace metals in mammalian hair and nails. EPA-600/4-79-049.
Weisskopf, M. G., Proctor, S. P., Wright, R. O., Schwartz, J., Spiro, A., Sparrow, D., et al. (2007). Cumulative lead exposure and cognitive performance among elderly men. Epidemiology, 18, 59–66.
Wilhelm, M., Hafner, D., Lombeck, I., & Ohnesorge, F. K. (1991). Monitoring of cadmium, copper, lead and zinc status in young-children using toenails—Comparison with scalp hair. Science of the Total Environment, 103, 199–207.
Wilkinson, T. J., & Sainsbury, R. (1998). A census-based comparison of centenarians in New Zealand with those in the United States. Journal of the American Geriatrics Society, 46, 488–491.
Wright, R. O., Tsaih, S. W., Schwartz, J., Spiro, A., McDonald, K., Weiss, S. T., et al. (2003). Lead exposure biomarkers and mini-mental status exam scores in older men. Epidemiology, 14, 713–718.
Xinhua. (2014). China Exclusive: Hainan declared as “World Longevity Island”.
Yoshizawa, K., Willett, W. C., Morris, S. J., Stampfer, M. J., Spiegelman, D., Rimm, E. B., et al. (1998). Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. Journal of the National Cancer Institute, 90, 1219–1224.
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This work was supported by the National Science Foundation of China (No. 41171082).
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Hao, Z., Li, Y., Liu, Y. et al. Hair elements and healthy aging: a cross-sectional study in Hainan Island, China. Environ Geochem Health 38, 723–735 (2016). https://doi.org/10.1007/s10653-015-9755-3
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DOI: https://doi.org/10.1007/s10653-015-9755-3