Abstract
Background
Multiple rapid swallows (MRS) during HREM assess post-deglutitive inhibition, LES relaxation, and subsequent esophageal contraction.
Aims
(1) To determine the relationship between MRS and single-swallow (SS) responses and (2) to determine if MRS provides information for symptomatic patients.
Methods
Healthy volunteers (HVs) and patients underwent HREM [30-s landmark, ten 5-mL SS, MRS (5 consecutive 2-mL swallows every 2–3 s)] and were analyzed with ManoView software version 3 with CC version 3.0.
Results
In 20 HVs, MRS response consisted of: (1) reduction in GEJ pressure; (2) absence of esophageal contractile activity during MRS; and (3) post-MRS peristaltic contraction greater than SS contractions. In 20 HVs and 403 patients, MRS IRP correlated with SS IRP (r = 0.65; p < 0.0001) and post-MRS contraction DCI correlated with SS DCI (r = 0.76; p < 0.0001). Abnormally elevated MRS IRP was seen in 68% type 2 achalasia, 50% type 3 achalasia, 47% EGJOO, and 9% jackhammer. Increased MRS DCI was seen in 53% type 2 achalasia, 92% type 3 achalasia, 10% EGJOO, 22% jackhammer, and 18% DES. Increased DCI post-MRS was seen in 38% patients with jackhammer, 8% type 3 achalasia, 12% EGJOO, and 9% DES. 14 out of 143 (10%) patients with normal or indeterminate results on SS analysis had at least one abnormality on MRS.
Conclusions
MRS IRP correlated with SS IRP, and post-MRS DCI correlated with SS DCI. Patients with defined CC disorders have abnormalities on MRS. There were MRS abnormalities in some patients with normal SS studies, most notably suggesting impaired LES relaxation and/or spastic esophageal motility. MRS may complement the baseline SS study analysis.
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AL conceived and designed the study; analyzed and interpreted the data; performed statistical analysis; and drafted the manuscript. DY performed statistical analysis; conceived and designed statistical analysis; analyzed and interpreted the data; and critically revised the manuscript. RB designed the study; interpreted the data; oversaw the analysis; and reviewed the manuscript. RK designed the study; interpreted the data; oversaw the analysis; and reviewed the manuscript. XL performed statistical analysis. AJ conceived and designed the study; interpreted the data; and reviewed the manuscript. MH collected the data and performed esophageal manometry. FF conceived and designed the study; interpreted the data; and reviewed the manuscript. ZM conceived and designed the study; interpreted the data; and reviewed the manuscript. RS conceived and designed the study; interpreted the data; and reviewed the manuscript. HPP conceived and designed the study; analyzed and interpreted the data; critically revised the manuscript for important intellectual content; and supervised the study.
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Leopold, A., Yu, D., Bhuta, R. et al. Multiple Rapid Swallows (MRS) Complements Single-Swallow (SS) Analysis for High-Resolution Esophageal Manometry (HREM). Dig Dis Sci 64, 2206–2213 (2019). https://doi.org/10.1007/s10620-019-05545-2
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DOI: https://doi.org/10.1007/s10620-019-05545-2