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Anti-Tobacco Mosaic Virus Chromone Derivatives from the Stems of Nicotiana tabacum

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Chemistry of Natural Compounds Aims and scope

Two new compounds (1 and 2), together with five known (3–7) chromone derivatives, were isolated from the stems of Nicotiana tabacum (a gene-edited mutant cultivated by Yunnan China Tobacco Industry Co., Ltd.). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1, 2, and 7 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 1, 2, and 7 exhibited high anti-TMV activities with inhibition rates of 38.4, 43.5, and 33.6% at the concentration of 20 μM. These rates are higher than that of positive control.

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Acknowledgment

This work was supported financially by the Foundation of Yunnan basic research program (2019FD086), the Foundation of Yunnan Tobacco Industry Co., Ltd. (2018JC07), the high-tech projects of Yunnan Province (2017ZE027), and the Yunnan Innovative Research Team for Discovery and Comprehensive Utilization of Functional Small Molecules in Medicinal Plants (Grant to Q.H.).

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Authors and Affiliations

  1. Technology Center, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Tao Zhou, Feng-Xian Yang, Bing-Biao Cai, Chun-Bo Liu, Jun Ling, Wei-Song Kong, Guang-Yu Yang & Xin Liu

  2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Tao Zhou, Fan Wu, Ya-Ning Zhu, Lu Liu, Guang-Yu Yang & Qiu-Fen Hu

Authors
  1. Tao Zhou
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  2. Feng-Xian Yang
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  3. Bing-Biao Cai
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  5. Ya-Ning Zhu
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  6. Lu Liu
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  8. Jun Ling
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  9. Wei-Song Kong
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  10. Guang-Yu Yang
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  11. Qiu-Fen Hu
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  12. Xin Liu
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Corresponding authors

Correspondence to Qiu-Fen Hu or Xin Liu.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2021, pp. 874–877.

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Zhou, T., Yang, FX., Cai, BB. et al. Anti-Tobacco Mosaic Virus Chromone Derivatives from the Stems of Nicotiana tabacum. Chem Nat Compd 57, 1019–1022 (2021). https://doi.org/10.1007/s10600-021-03540-6

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  • DOI: https://doi.org/10.1007/s10600-021-03540-6

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