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Methyl 3-aryl(pyridyl)-5-oxopyrrolidine-2-carboxylates: synthesis and structure

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Chemistry of Heterocyclic Compounds Aims and scope

A convenient diastereoselective method for the preparation of methyl (2R*,3R*)-3-aryl(pyridyl)-5-oxopyrrolidine-2-carboxylates was developed on the basis of the neutralization reaction of diastereohomogeneous dimethyl (2R*,3R*)-3-aryl(pyridyl)glutamate hydrochlorides.

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This work was supported by the Russian Ministry of Education (project FSZN-2020-0026) and the Russian Science Foundation (project 21-15-00192).

The spectral characteristics and elemental analysis data of the synthesized compounds were obtained using the equipment of the Collective Use Center ''Physicochemical methods for the study of nitro compounds, coordination compounds, biologically active substances, and nanostructured materials'' of the Interdisciplinary Resource Center for Collective Use ''Modern physicochemical methods of the formation and study of materials for the needs of industry, science, and education'' of the Herzen State Pedagogical University of Russia.

The X-ray structural study was carried out within the framework of the State Assignment to the Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”.

The X-ray structural study was performed using the equipment of the Distributed collective spectroanalytical center for the study of the structure, composition, and properties of substances and materials of the Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”.

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Authors and Affiliations

  1. Herzen State Pedagogical University of Russia, 48 Moyka River Embankment, Saint Petersburg, 191186, Russia

    Natal’ya V. Gorodnicheva, Olga S. Vasil’eva, Evgeny S. Ostroglyadov, Ruslan I. Baichurin & Sergey V. Makarenko

  2. A. E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzova St, Kazan, 420088, Russia

    Igor A. Litvinov

Authors
  1. Natal’ya V. Gorodnicheva
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  2. Olga S. Vasil’eva
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  3. Evgeny S. Ostroglyadov
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  4. Ruslan I. Baichurin
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  5. Igor A. Litvinov
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  6. Sergey V. Makarenko
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Corresponding author

Correspondence to Sergey V. Makarenko.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(1/2), 48–53

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Gorodnicheva, N.V., Vasil’eva, O.S., Ostroglyadov, E.S. et al. Methyl 3-aryl(pyridyl)-5-oxopyrrolidine-2-carboxylates: synthesis and structure. Chem Heterocycl Comp 59, 48–53 (2023). https://doi.org/10.1007/s10593-023-03161-7

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  • DOI: https://doi.org/10.1007/s10593-023-03161-7

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