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Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

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A Correction to this article was published on 18 December 2019

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Abstract

In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.

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Change history

  • 18 December 2019

    In the original publication of the article, one of the co-authors name was mistakenly missed out. It has been updated in this correction.

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Acknowledgments

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through research groups program under Grant Number R.G.P. 1/19/40. Thomas Heinze acknowledged financially supported by the DFG-funded Collaborative Research Centre PolyTarget (SFB 1278, Project A02).

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Authors and Affiliations

  1. Nanomaterials and Systems for Renewable Energy Laboratory, Research and Technology Center of Energy, Technoparc borje cedria, BP 095, Hammam Lif, Tunisia

    Sherif M. A. S. Keshk

  2. Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia

    Adel A. El-Zahhar & Samir Bondock

  3. Hot Labs., Nuclear Chemistry Department, Center Atomic Energy Authority, Cairo, 13759, Egypt

    Adel A. El-Zahhar

  4. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 42805, Jeddah, 21589, Saudi Arabia

    Qana A. Alsulami

  5. Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia

    Mariusz Jaremko

  6. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    Samir Bondock

  7. Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany

    Thomas Heinze

Authors
  1. Sherif M. A. S. Keshk
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  2. Adel A. El-Zahhar
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  3. Qana A. Alsulami
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  4. Mariusz Jaremko
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  5. Samir Bondock
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  6. Thomas Heinze
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Correspondence to Sherif M. A. S. Keshk.

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Keshk, S.M.A.S., El-Zahhar, A.A., Alsulami, Q.A. et al. Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite. Cellulose 27, 1603–1618 (2020). https://doi.org/10.1007/s10570-019-02887-y

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