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Update on gastric cancer treatments and gene therapies

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Abstract

Gastric cancer is an active topic of clinical and basic research due to high morbidity and mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric cancer patients, but drug resistance, either acquired or primary, is the main cause for treatment failure. Differences in development and response to cancer treatments have been observed among ethnically diverse GC patient populations. In spite of major incidence, GC Asian patients have a significantly better prognosis and response to treatments than Caucasian ones due to genetic discordances between the two populations. Gene therapy could be an alternative strategy to overcome such issues and especially CRISPR/Cas9 represents one of the most intriguing gene-editing system. Thus, in this review article, we want to provide an update on the currently used therapies for the treatment of advanced GC.

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Dr. Alessio Biagioni was supported by a postdoctoral fellowship of the Italian Foundation for Cancer Research (AIRC).

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  1. Lucia Magnelli and Laura Papucci equally contributed to this manuscript as last authors

Authors and Affiliations

  1. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale G.B. Morgagni 50, 50134, Florence, Italy

    Alessio Biagioni, Sara Peri, Nicola Schiavone, Lucia Magnelli & Laura Papucci

  2. Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy

    Ileana Skalamera & Fabio Cianchi

  3. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy

    Sara Peri

  4. Medical Oncology Unit, Department of Oncology and Robotic Surgery, AOU Careggi, Largo Brambilla 3, 50134, Florence, Italy

    Elisa Giommoni

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Biagioni, A., Skalamera, I., Peri, S. et al. Update on gastric cancer treatments and gene therapies. Cancer Metastasis Rev 38, 537–548 (2019). https://doi.org/10.1007/s10555-019-09803-7

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