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Endothelial dysfunction, subclinical atherosclerosis and LDL cholesterol are the independent predictors of left atrial functions in hypertension

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Abstract

Left atrial function has an important role in determining optimal performance of the heart. Increase of left atrial dysfunction and volume are poor prognostic factors. In this study, we investigated independent determinants of left atrial function in non-diabetic patients with de novo hypertension. The study included 124 consecutive non-diabetic patients with de novo hypertension. Brachial artery flow-mediated dilatation, carotid intima-media thickness, transthoracic echocardiography, 24-h rhythm holter, and aortic stiffness measurements were recorded. In echocardiography, left atrial maximum (LAMaV) and minimum (LAMiV) volumes were calculated. Left atrium total emptying fraction (LATEF) and total emptying volume (LATEV) were divided into two groups according to the mean levels. Multivariate analysis was performed after correlation analysis for LATEV and LATEF mean levels. By logistic regression analysis, systolic blood pressure (OR 0.882, 95% CI 0.784–0.992, p = 0.036), percent of flow-mediated dilation (OR 0.747, 95% CI 0.595–0.938, p = 0.012), and presence of carotid plaque (OR 0.014, 95% CI 0.001–0.188, p = 0.001) were found as independent variables that determine LATEF. Age (OR  0.879, 95% CI 0.795–0.972, p = 0.012), smoking (OR  23.739, 95% CI 2.699–208.810, p = 0.004), left ventricular mass index (OR  1.052, 95% CI 1.012–1.094, p = 0.011), mitrale E-wave velocity (OR 1.108, 95% CI 1.031–1.191, p = 0.005) and LDL (low-density lipoprotein) cholesterol (OR 0.942, 95% CI 0.911–0.974, p = 0.001) were independent predictors of LATEV. In non-diabetic patients with de novo hypertension endothelial dysfunction, subclinical atherosclerosis and LDL cholesterol levels independently affect left atrial function.

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Authors and Affiliations

  1. Department of Cardiology, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Turkey

    Mustafa Çetin, Turan Erdoğan, Elif Ergül, Emre Durakoğlugil, Hüseyin Durak & Yüksel Çiçek

  2. Department of Cardiology, Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey

    Tuncay Kırış

  3. Department of Cardiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Turkey

    Ali Gökhan Özyıldız

  4. Department of Cardiology, Ahi Evren Training and Research Hospital, Trabzon, Turkey

    Ezgi Kalaycıoğlu

Authors
  1. Mustafa Çetin
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  2. Turan Erdoğan
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  3. Tuncay Kırış
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  4. Ali Gökhan Özyıldız
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  5. Elif Ergül
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  6. Emre Durakoğlugil
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  8. Ezgi Kalaycıoğlu
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  9. Yüksel Çiçek
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All authors have made substantial contributions to the conception and design of the study, acquisition of data, or analysis and interpretation; drafting the article or revising it critically for important intellectual content and final approval of the version to be submitted. All authors endorse the data and conclusions.

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Correspondence to Ali Gökhan Özyıldız.

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The study was performed in accordance with the principles stated in the Declaration of Helsinki and approved by the R.T.E. University Faculty of Medicine Ethics Committee.

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Çetin, M., Erdoğan, T., Kırış, T. et al. Endothelial dysfunction, subclinical atherosclerosis and LDL cholesterol are the independent predictors of left atrial functions in hypertension. Int J Cardiovasc Imaging 36, 69–77 (2020). https://doi.org/10.1007/s10554-019-01699-2

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  • DOI: https://doi.org/10.1007/s10554-019-01699-2

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