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Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

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Abstract

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case–control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43–0.62, p trend < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49–0.90, p trend = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13–1.74, p trend = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14–1.65, p trend < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84–0.97).

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Acknowledgments

Shu-Chun Chuang worked on this study during the tenure of a Special Training Award from the International Agency for Research on Cancer. This INHANCE Consortium was supported by a grant from the US National Institutes of Health (NIH), National Cancer Institute (NCI), (R03CA113157) and National Institute for Dental and Craniofacial Research (NIDCR; R03DE016611). The individual studies were funded by the following grants: Milan study: Italian Association for Research on Cancer (AIRC). Aviano: Italian Association for Research on Cancer (AIRC), Italian League against Cancer and Italian Ministry of Research. France study: Swiss League against Cancer (KFS1069-09-2000), Fribourg League against Cancer (FOR381.88), Swiss Cancer Research (AKT 617), and Gustave-Roussy Institute (88D28). Italy Multicenter study: Italian Association for Research on Cancer (AIRC), Italian League against Cancer and Italian Ministry of Research. Swiss study: Swiss League against Cancer and the Swiss Research against Cancer/Oncosuisse (KFS-700, OCS-1633). Central Europe study: World Cancer Research Fund and the European Commission’s INCO-COPERNICUS Program (Contract No. IC15-CT98-0332). Seattle study: National Institutes of Health (NIH) US (R01CA048996, R01DE012609). North Carolina study: National Institutes of Health (NIH) US (R01CA61188), and in part by a grant from the National Institute of Environmental Health Sciences (P30ES010126). Tampa study: National Institutes of Health (NIH) US (P01CA068384, K07CA104231, R01DE13158). Los Angeles study: National Institute of Health (NIH) US (P50CA90388, R01DA11386, R03CA77954, T32CA09142, U01CA96134, R21ES011667) and the Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center. Puerto Rico study: jointly funded by National Institutes of Health (NCI) US and NIDCR intramural programs. Latin America study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundac¸a˜o de Amparo a` Pesquisa no. Estado de Sa˜o Paulo (FAPESP) (No 01/01768-2), and European Commission (IC18-CT97-0222). IARC Multicenter study: Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government (FIS 97/0024, FIS 97/0662, BAE 01/5013), International Union Against Cancer (UICC), and Yamagiwa-Yoshida Memorial International Cancer Study Grant. Boston study: National Institutes of Health (NIH) US (R01CA078609, R01CA100679). Rome study: AIRC (Italian Agency for Research on Cancer). US Multicenter study: The Intramural Program of the National Cancer Institute, National Institutes of Health, USA. MSKCC study: NIH (R01CA51845). Seattle-LEO study: NIH(R01CA30022). Western Europe Study: European Commission’s 5th Framework Program (Contract No. QLK1-2001-00182), Italian Association for Cancer Research, Compagnia di San Paolo/FIRMS, Region Piemonte, and Padova University (Contract No. CPDA057222). Saarland study: Ministry of Science, Research and Arts Baden-Wϋrttemberg. Heidelberg study: Grant No. 01GB9702/3 from the German Ministry of Education and Research. Japan study: Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan (17015052) and grant for the Third-Term Comprehensive 10-year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan (H20-002).

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Authors and Affiliations

  1. Imperial College London, London, UK

    Shu-Chun Chuang

  2. International Agency for Research on Cancer (IARC), Lyon, France

    Shu-Chun Chuang, Mazda Jenab, Silvia Franceschi, Maria Paula Curado, Gilles Ferro, Paul Brennan & Mia Hashibe

  3. UCLA School of Public Health, Los Angeles, CA, USA

    Julia E. Heck & Zuo-Feng Zhang

  4. Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

    Cristina Bosetti & Carlo La Vecchia

  5. Aviano Cancer Centre, Aviano, Italy

    Renato Talamini & Luigino Dal Maso

  6. Aichi Cancer Center Research Institute, Nagoya, Japan

    Keitaro Matsuo

  7. Institut Català d’Oncologia, Barcelona, Spain

    Xavier Castellsague

  8. Instituto de Investigación Epidemiológica, San José, Costa Rica

    Rolando Herrero

  9. National Cancer Institute, Bethesda, MA, USA

    Deborah M. Winn & Mark Purdue

  10. Department of Occupational Health, University of Milan, Milan, Italy

    Carlo La Vecchia

  11. Department of Epidemiology and Environmental Health Sciences and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA

    Hal Morgenstern

  12. Institut Universitaire de Medecine Sociale et Preventive, Lausanne, Switzerland

    Fabio Levi

  13. Brown University, Providence, RI, USA

    Karl Kelsey

  14. Boston University of Public Health, Boston, MA, USA

    Michael D. McClean

  15. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Thomas Vaughan, Chu Chen & Stephen M. Schwartz

  16. Pen State College of Medicine, Philadelphia, PA, USA

    Philip Lazarus & Joshua Muscat

  17. University of Heidelberg, Heidelberg, Germany

    Heribert Ramroth

  18. Departemento Medicina Preventiva, Universidade de Sao Paulo, Sao Paulo, Brazil

    Jose Eluf-Neto

  19. New York University School of Medicine, New York, NY, USA

    Richard B. Hayes

  20. Institute of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy

    Stefania Boccia

  21. IRCCS San Raffaele Pisana, Rome, Italy

    Stefania Boccia

  22. Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy

    Gabriella Cadoni

  23. Cancer Research Center, Moscow, Russia

    David Zaridze

  24. Escola Nacional de Saude Publica, Rio de Janeiro, Brazil

    Sergio Koifman

  25. Bermen Institute for Prevention Research and Social Med, Bermen, Germany

    Wolfgang Ahrens

  26. INSERM, Paris, France

    Simone Benhamou

  27. Institute of Oncology Angel H. Roffo, Buenos Aires, Argentina

    Elena Matos

  28. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Athens, Greece

    Pagona Lagiou

  29. Institute of Occupational Medicine, Lodz, Poland

    Neonilla Szeszenia-Dabrowska

  30. School of Public Health, University of North Carolina, Chapel Hill, NC, USA

    Andrew F. Olshan

  31. Institute of Oncology and Radiology, Havana, Cuba

    Leticia Fernandez

  32. Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, Brazil

    Ana Menezes

  33. Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain

    Antonio Agudo

  34. Hospital de Clinicas de Porto Allegre, Porto Alegre, Brazil

    Alexander W. Daudt

  35. Unit of Cancer Epidemiology, Turin, Italy

    Franco Merletti

  36. School of Medicine and Dentistry, University of Aberdeen, Scotland, UK

    Gary J. Macfarlane

  37. Cancer Registry of Norway, Oslo, Norway

    Kristina Kjaerheim

  38. Institute of Public Health, Bucharest, Romania

    Dana Mates

  39. Institute of Hygiene and Epidemiology, Prague, Czech Republic

    Ivana Holcatova

  40. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Stimson Schantz & Guo-Pei Yu

  41. Department of Environmental Medicine and Public Health, School of Medicine, University of Padova, Padua, Italy

    Lorenzo Simonato

  42. German Cancer Research Center, Heidelberg, Germany

    Hermann Brenner & Heiko Mueller

  43. Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

    David I. Conway

  44. University of Newcastle Dental School, Newcastle, UK

    Peter Thomson

  45. Specialized State Health Institute, Banská Bystrica, Slovakia

    Eleonora Fabianova

  46. Croatian National Cancer Registry, Zagreb, Croatia

    Ariana Znaor

  47. National Institute of Environmental Health, Budapest, Hungary

    Peter Rudnai

  48. Trinity College School of Dental Science, Dublin, Ireland

    Claire M. Healy

  49. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA

    Paolo Boffetta

  50. International Prevention Research Institute, Lyon, France

    Paolo Boffetta

  51. Division of Public Health, Department of Family & Preventive Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT, 84108, USA

    Mia Hashibe

Authors
  1. Shu-Chun Chuang
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  2. Mazda Jenab
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  3. Julia E. Heck
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  4. Cristina Bosetti
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  5. Renato Talamini
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  6. Keitaro Matsuo
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  7. Xavier Castellsague
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  8. Silvia Franceschi
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  9. Rolando Herrero
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  10. Deborah M. Winn
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  11. Carlo La Vecchia
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  12. Hal Morgenstern
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  13. Zuo-Feng Zhang
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  14. Fabio Levi
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  15. Luigino Dal Maso
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  16. Karl Kelsey
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  17. Michael D. McClean
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  18. Thomas Vaughan
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  19. Philip Lazarus
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  20. Joshua Muscat
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  21. Heribert Ramroth
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  22. Chu Chen
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  23. Stephen M. Schwartz
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Corresponding author

Correspondence to Mia Hashibe.

Appendices

Appendix 1

See Table 8.

Table 8 Summary of individual studies in INHANCE consortium pooled data version 1.3, by region and study period
Full size table

Appendix 2

See Table 9.

Table 9 Property of Questionnaires
Full size table

Appendix 3

See Tables 10 and 11.

Table 10 Odds ratios (OR) and 95% confidence intervals (CI) for selected food groups and head and neck cancer risks by tobacco smoking status
Full size table
Table 11 Odds ratios (OR) and 95% confidence intervals (CI) for selected food groups and head and neck cancer risks by alcohol drinking intensity
Full size table

Appendix 4

See Figs. 1, 2, 3, 4, 5, 6.

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Chuang, SC., Jenab, M., Heck, J.E. et al. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium. Cancer Causes Control 23, 69–88 (2012). https://doi.org/10.1007/s10552-011-9857-x

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