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Smoking and survival in male breast cancer patients

  • Epidemiology
  • Published:
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Abstract

The purpose of the article was to assess whether smoking affects survival in male breast cancer patients for the overall population and when stratified by race, ethnicity, and socioeconomic status. Data were obtained by linking the 1996–2007 Florida Cancer Data System, the Florida Agency for Health Care Administration, and the US Census. Inclusion criteria were males ≥18 years, diagnosed with breast cancer and residing in Florida (n = 1573). To analyze the association between smoking and survival, we performed sequential multivariate Cox proportional hazards regression models with progressive adjustment for main confounders. Compared to never smokers, worse survival was found in current (hazard ratio = 1.63; 95 % CI = 1.23–2.16) but not in former smokers (1.26; 0.99–1.59). Those who smoked ≥1 packs/day had worse survival (2.48; 1.59–3.87) than never smokers with a significant dose–response (P for linear trend <0.001). Race-ethnic stratified models comparing current and former smokers with never smokers found significant differences among Whites [(1.88; 1.44–2.44) and (1.31; 1.04–1.65, respectively)] and non-Hispanics, [(1.73; 1.31–2.28) and (1.31; 1.04–1.66, respectively)]. Overall, current smokers were found to have significantly reduced survival, which was worse by intensity of smoking. Also, any smoking history is associated with worse survival in White and non-Hispanic male breast cancer patients compared to never smokers. Thus, male breast cancer patients should be advised to quit smoking.

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Abbreviations

SES:

Socioeconomic status

FCDS:

Florida Cancer Data System

AHCA:

Agency for health care administration

HR:

Hazard ratio

CI:

Confidence interval

CA:

Carcinoma

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Acknowledgments

This study was funded by the James & Esther King Florida Biomedical Research Program (Grant 10KG-06).

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Authors and Affiliations

  1. Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA

    Alicia Padron-Monedero, Tulay Koru-Sengul, Feng Miao, Damien Hansra, David J. Lee & Margaret M. Byrne

  2. National Centre for Epidemiology, Instituto de Salud Carlos III. Madrid, Monforte de Lemos 5, Madrid, Spain

    Alicia Padron-Monedero

  3. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA

    Tulay Koru-Sengul, Stacey L. Tannenbaum, Feng Miao & Margaret M. Byrne

Authors
  1. Alicia Padron-Monedero
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  2. Tulay Koru-Sengul
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  3. Stacey L. Tannenbaum
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  4. Feng Miao
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  5. Damien Hansra
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  6. David J. Lee
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  7. Margaret M. Byrne
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Corresponding author

Correspondence to Alicia Padron-Monedero.

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The authors declare that they have no conflict of interest.

Ethical approval

This manuscript complies with the current laws of the country in which the research was performed. The study was approved by the Institutional Review Boards of the University of Miami and the Florida Department of Health in the US, and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Padron-Monedero, A., Koru-Sengul, T., Tannenbaum, S.L. et al. Smoking and survival in male breast cancer patients. Breast Cancer Res Treat 153, 679–687 (2015). https://doi.org/10.1007/s10549-015-3582-1

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  • DOI: https://doi.org/10.1007/s10549-015-3582-1

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