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Fingolimod loaded niosomes attenuates sevoflurane induced cognitive impairments

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Abstract

Neurocognition is a severe, neurological challenge caused due to sevoflurane application for induction of anaesthesia. The plan of this study is to investigate the effect of fingolimod loaded niosomes on the cognitive impairment induced by sevoflurane. Span 40 and cholesterol were used in reverse phase evaporation techniques for the preparation of fingolimod -loaded niosomes. The positively charged niosomes were obtained by using chloride salts of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The Fingolimod loaded niosomes has average particle size of 223.5 nm and the surface charge measured as + 8.7 ± 1.2 mV in presence of DOTAP. The Fingolimod loaded niosomes formulation shows higher entrapment efficiency. Fingolimod loaded positively charged niosomes were efficiently retained drug and increase the sustain release property. Fingolimod niosomes increases the spontaneous alternation in Y maze and reduces the escape latency in the Morris water maze test, which leads to significant (p < 0.01) improvement in spatial short-term and long-term memory. The neuronal death in the hippocampus due to the sevoflurane exposure was attenuated by fingolimod loaded niosomes, which was proved by histopathological study. It could be defined that fingolimod loaded niosomes attenuates the sevoflurane induced cognitive impairment.

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Acknowledgements

XingDa Li is extremely thankful to Department of Anesthesiology, Linyi Central Hospital, Linyi, China for providing desired facility to carry out the research activity and other relevant supports.

Funding

This study didn’t receive any specific grant/fund from any funding agencies in the public, commercial, or nonprofits sector.

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Authors and Affiliations

  1. Department of Anesthesiology, Linyi Central Hospital, Linyi, 276400, Shandong, China

    Hongliang Weng, Xiaoguang Liu, Yongying Ren, Yujian Li & XingDa Li

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  1. Hongliang Weng
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  2. Xiaoguang Liu
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  3. Yongying Ren
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  4. Yujian Li
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  5. XingDa Li
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Contributions

HW and XL are associated in planning the work. The experiments were carried out by XL and YR whereas HW, YR and XL were involved in data handling and processing. All the authors contributed equally in preparing the manuscript. All authors read and approved the final manuscript.

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Correspondence to XingDa Li.

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Weng, H., Liu, X., Ren, Y. et al. Fingolimod loaded niosomes attenuates sevoflurane induced cognitive impairments. Biomed Microdevices 24, 5 (2022). https://doi.org/10.1007/s10544-021-00603-x

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