Skip to main content
SpringerLink
Log in

Cellulose nanocrystals-based materials as hemostatic agents for wound dressings: a review

  • Published:
Biomedical Microdevices Aims and scope Submit manuscript

Abstract

Wound dressings are devices used to stop bleeding and provide appropriate environmental conditions to accelerate wound healing. The effectiveness of wound dressing materials can be crucial to prevent deaths from excessive bleeding in surgeries and promote complete restoration of the injury. Some requirements for an ideal wound dressing are rapid hemostatic effect, high swelling capacity, antibacterial properties, biocompatibility, biodegradability, and mechanical strength. However, finding all these properties in a single material remains a challenge. In this context, nanocomposites have demonstrated an excellent capacity for this application because of their multifunctionality. One of the emerging materials used in nanocomposite manufacture is cellulose nanocrystals (CNCs), which are rod-like crystalline nanometric structures present on cellulose chains. These nanoparticles are attractive for wound healing applications because of their high aspect ratio, high mechanical properties, functionality and low density. Hence, this work aimed to present an overview of nanocomposites constituted by CNCs for wound healing applications. The review focuses on the most common materials used as matrices, the types of dressing, and their fabrication techniques. Novel wound dressings composites have improved hemostatic, swelling, and mechanical properties compared to other pure biopolymers while preserving their other biological properties. Films, nanofibers mats, sponges, and hydrogels have been prepared with CNCs nanocomposites, and in vitro and in vivo tests have proved their suitability for wound healing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Reproduced with permission from Ref. (Cheng et al. 2016a). Copyright 2016, Springer Nature

Fig. 7

Reproduced with permission from Ref. (Cheng et al. 2016a). Copyright 2016, Springer Nature

Fig. 8

Reproduced with permission from Ref. (Liu et al. 2018). Copyright 2018, Elsevier

Fig. 9

Reproduced with permission from Ref. (Liu et al. 2018). Copyright 2018, Elsevier

Fig. 10

Copyright 2017, ACS Publications

Similar content being viewed by others

References

  • T. Adschiri, Y.W. Lee, M. Goto, S. Takami, Green Chem. 13, 1380 (2011)

    Article  Google Scholar 

  • P. Agulhon, M. Robitzer, L. David, F. Quignard, Biomacromol 13, 215 (2012)

    Article  Google Scholar 

  • N. Akhavan-Kharazian, H. Izadi-Vasafi, Int. J. Biol. Macromol. 133, 881 (2019)

    Article  Google Scholar 

  • I.F.H. AI-Jawhari, Handbook of Nanomaterial Nanocomposites Energy Environmental Applications (2020), p. 1

  • M.G. Albu, I. Titorencu, M.V. Ghica, in Biomaterials Applications for Nanomedicine, edited by R. Pignatello (InTech, Rijeka, 2011), pp. 333–357

  • N. Annabi, J.W. Nichol, X. Zhong, C. Ji, S. Koshy, A. Khademhosseini, F. Dehghani, Tissue Eng. Part B Rev. 16, 371 (2010)

    Article  Google Scholar 

  • P. Aramwit, Introduction to Biomaterials for Wound Healing (Elsevier Ltd, London, 2016)

    Book  Google Scholar 

  • D. Archana, P.K. Dutta, J. Dutta, Chitin and Chitosan for Regenerative Medicine (2016)

  • D.K. Arserim-Uçar, F. Korel, L.S. Liu, K.L. Yam, Food Chem. 336, 127597 (2021)

    Article  Google Scholar 

  • L. Bacakova, J. Pajorova, M. Bacakova, A. Skogberg, P. Kallio, K. Kolarova, V. Svorcik, Nanomaterials 9, 164 (2019)

    Article  Google Scholar 

  • B. Balakrishnan, M. Mohanty, P.R. Umashankar, A. Jayakrishnan, Biomaterials 26, 6335 (2005)

    Article  Google Scholar 

  • S. Beck-Candanedo, M. Roman, D.G. Gray, Biomacromol 6, 1048 (2005)

    Article  Google Scholar 

  • A.M. Behrens, M.J. Sikorski, P. Kofinas, J. Biomed. Mater. Res. Part A 102, 4182 (2014)

    Article  Google Scholar 

  • J.S. Boateng, K.H. Matthews, H.N.E. Stevens, G.M. Eccleston, J. Pharm. Sci. 97, 2892 (2008)

    Article  Google Scholar 

  • A.D.J. Bombin, N.J. Dunne, H.O. McCarthy, Mater. Sci. Eng. C 114, 110994 (2020)

    Article  Google Scholar 

  • Bowil/Biotech (2021)

  • R. Brandes, L. De Souza, C. Carminatti, D. Recouvreux, Int. J. Nanosci. 19, 1 (2020)

    Article  Google Scholar 

  • X. Cao, B. Ding, J. Yu, S.S. Al-deyab, Carbohydr. Polym. 90, 1075 (2012)

    Article  Google Scholar 

  • M. Capozza, G. Pansini, A.M. Buccoliero, G. Barbagli, B. Ashraf-Noubari, F. Mariotti, F. Ammannati, Iran. J. Neurosurg. 2, 20 (2016)

    Article  Google Scholar 

  • K.C. Castro, M.G.N. Campos, L.H.I. Mei, Int. J. Biol. Macromol. 173, 251 (2021)

    Article  Google Scholar 

  • Celluforce (2021)

  • About CelluForce (2021)

  • P.R. Chawla, I.B. Bajaj, S.A. Survase, R.S. Singhal, Food Technol. Biotechnol. 47, 107 (2009)

    Google Scholar 

  • X. Chen, X. Deng, W. Shen, L. Jiang, BioResources 7, 4237 (2012)

    Google Scholar 

  • Y. Chen, Y. Wang, Q. Yang, Y. Liao, B. Zhu, G. Zhao, R. Shen, X. Lu, S. Qu, J. Mater. Chem. B 6, 4502 (2018)

    Article  Google Scholar 

  • Y. Chen, L. Wu, P. Li, X. Hao, X. Yang, G. Xi, W. Liu, Y. Feng, H. He, C. Shi, Macromol. Biosci. 1900370, 1 (2020)

    Google Scholar 

  • W. Cheng, J. He, Y. Wu, C. Song, S. Xie, Y. Huang, B. Fu, Cellulose 20, 2547 (2013)

    Article  Google Scholar 

  • W. Cheng, J. He, M. Chen, D. Li, H. Li, L. Chen, Y. Cao, J. Wang, Y. Huang, Fibers Polym. 17, 1277 (2016a)

    Article  Google Scholar 

  • W. Cheng, H. Li, X. Zheng, L. Chen, F. Cheng, J. He, K. Liu, P. Cai, X. Wang, Y. Huang, Phys. Chem. Chem. Phys. 18, 29183 (2016b)

    Article  Google Scholar 

  • F. Cheng, C. Liu, X. Wei, T. Yan, H. Li, J. He, Y. Huang, A.C.S. Sustain, Chem. Eng. 5, 3819 (2017)

    Google Scholar 

  • B. Cohen, A. Shefy-Peleg, M. Zilberman, J. Biomater. Sci. Polym. Ed. 25, 224 (2014)

    Article  Google Scholar 

  • D.S. da Perez, S. Montanari, M.R. Vignon, Biomacromolecules 4, 1417 (2003)

    Article  Google Scholar 

  • T. Dai, M. Tanaka, Y.-Y. Huang, M.R. Hamblin, Chitosan Preparations for Wound-Healing Effects (2011)

  • C.A. de Assis, C. Houtman, R. Phillips, E.M.T. Bilek, O.J. Rojas, L. Pal, M.S. Peresin, H. Jameel, R. Gonzalez, Biofuels Bioprod. Biorefining 11, 682 (2017)

    Article  Google Scholar 

  • I.A.A. de Fernandes, A.C. Pedro, V.R. Ribeiro, D.G. Bortolini, M.S.C. Ozaki, G.M. Maciel, C.W.I. Haminiuk, Int. J. Biol. Macromol. 164, 2598 (2020)

    Article  Google Scholar 

  • B. Deepa, E. Abraham, N. Cordeiro, M. Faria, G. Primc, Y. Pottathara, M. Leskovšek, M. Gorjanc, M. Mozetič, S. Thomas, L.A. Pothan, Heliyon 6, e03266 (2020)

    Article  Google Scholar 

  • M. Djabourov, P. Papon, Polymer (guildf) 24, 537 (1983)

    Article  Google Scholar 

  • F. Dong, S. Li, Polymers (basel) 10, 673 (2018)

    Article  Google Scholar 

  • H. Du, C. Liu, X. Mu, W. Gong, D. Lv, Y. Hong, C. Si, B. Li, Cellulose 23, 2389 (2016)

    Article  Google Scholar 

  • L. Du, J. Wang, Y. Zhang, C. Qi, M.P. Wolcott, Z. Yu, Nanomaterials 7, 1 (2017)

    Article  Google Scholar 

  • H. Du, W. Liu, M. Zhang, C. Si, X. Zhang, B. Li, Carbohydr. Polym. 209, 130 (2019a)

    Article  Google Scholar 

  • W.B. Du, A. Deng, J. Guo, J. Chen, H. Li, Y. Gao, Carbohydr. Polym. 223, 115084 (2019b)

    Article  Google Scholar 

  • R.D. Farahani, M. Dubé, D. Therriault, Adv. Mater. 28, 5794 (2016)

    Article  Google Scholar 

  • R.D. Farahani, M. Dubé, Adv. Eng. Mater. 20, 1 (2018)

    Google Scholar 

  • M. Fazil, S. Nikhat, J. Ethnopharmacol. 257, 112878 (2020)

    Article  Google Scholar 

  • E.J. Foster, R.J. Moon, U.P. Agarwal, M.J. Bortner, J. Bras, S. Camarero-Espinosa, K.J. Chan, M.J.D. Clift, E.D. Cranston, S.J. Eichhorn, D.M. Fox, W.Y. Hamad, L. Heux, B. Jean, M. Korey, W. Nieh, K.J. Ong, M.S. Reid, S. Renneckar, R. Roberts, J.A. Shatkin, J. Simonsen, K. Stinson-Bagby, N. Wanasekara, J. Youngblood, Chem. Soc. Rev. 47, 2609 (2018)

    Article  Google Scholar 

  • A. Gaspar-Pintiliescu, A.M. Stanciuc, O. Craciunescu, Int. J. Biol. Macromol. 138, 854 (2019)

    Article  Google Scholar 

  • C. Ghobril, M.W. Grinstaff, Chem. Soc. Rev. 44, 1820 (2015)

    Article  Google Scholar 

  • L. Golbaghi, M. Khamforoush, T. Hatami, Carbohydr. Polym. 174, 780 (2017)

    Article  Google Scholar 

  • A.C.D.O. Gonzalez, Z.D.A. Andrade, T.F. Costa, A.R.A.P. Medrado, An. Bras. Dermatol. 91, 614 (2016)

    Article  Google Scholar 

  • S. Gopi, P. Balakrishnan, D. Chandradhara, D. Poovathankandy, S. Thomas, Mater. Today Chem. 13, 59 (2019)

    Article  Google Scholar 

  • M.F.P. Graça, S.P. Miguel, C.S.D. Cabral, I.J. Correia, Carbohydr. Polym. 241, 116364 (2020)

    Article  Google Scholar 

  • Y. Habibi, L.A. Lucia, O.J. Rojas, Chem. Rev. 110, 3479 (2010)

    Article  Google Scholar 

  • D.M. Hariyadi, N. Islam, Adv. Pharmacol. Pharm. Sci. 2020, 1 (2020)

    Article  Google Scholar 

  • T. Hatami, J. Vigano, L.H.I. Mei, J. Martinez, J. Supercrit. Fluids 160, 104791 (2020)

    Article  Google Scholar 

  • S.S.Z. Hindi, Nanosci. Nanotechnol. Res. 4, 17 (2017)

    Google Scholar 

  • A. Hivechi, S. Hajir Bahrami, R.A. Siegel, Int. J. Biol. Macromol. 124, 411 (2019)

    Article  Google Scholar 

  • W. Huang, Y. Wang, Z. Huang, X. Wang, L. Chen, Y. Zhang, L. Zhang, A.C.S. Appl, Mater. Interfaces 10, 41076 (2018)

    Article  Google Scholar 

  • R.W. Hutchinson, K. George, D. Johns, L. Craven, G. Zhang, P. Shnoda, Cellulose 20, 537 (2013)

    Article  Google Scholar 

  • A. Isogai, T. Saito, H. Fukuzumi, Nanoscale 3, 71 (2011)

    Article  Google Scholar 

  • Z.M. Jessop, A. Al-Sabah, N. Gao, S. Kyle, B. Thomas, N. Badiei, K. Hawkins, I.S. Whitaker, Biofabrication 11, 045006 (2019)

    Article  Google Scholar 

  • A.F. Jozala, L.C. de Lencastre-Novaes, A.M. Lopes, V. de Carvalho Santos-Ebinuma, P.G. Mazzola, A. Pessoa, D. Grotto, M. Gerenutti, M.V. Chaud, Appl. Microbiol. Biotechnol. 100, 2063 (2016)

    Article  Google Scholar 

  • H. Kargarzadeh, M. Mariano, D. Gopakumar, I. Ahmad, S. Thomas, A. Dufresne, J. Huang, N. Lin, Advances in Cellulose Nanomaterials (Springer, Netherlands, 2018)

    Book  Google Scholar 

  • A. Karimian, H. Parsian, M. Majidinia, M. Rahimi, S.M. Mir, H. Samadi Kafil, V. Shafiei-Irannejad, M. Kheyrollah, H. Ostadi, B. Yousefi, Int. J. Biol. Macromol. 133, 850 (2019)

    Article  Google Scholar 

  • H.P.S.A. Khalil, Y. Davoudpour, M.N. Islam, A. Mustapha, K. Sudesh, R. Dungani, M. Jawaid, Carbohydr. Polym. 99, 649 (2014)

    Article  Google Scholar 

  • M. Khamforoush, T. Asgari, T. Hatami, F. Dabirian, Korean J. Chem. Eng. 31, 1695 (2014a)

    Article  Google Scholar 

  • M. Khamforoush, T. Hatami, M. Mahjob, F. Dabirian, A. Zandi, Iran. Polym. J. (english Ed.) 23, 569 (2014b)

    Article  Google Scholar 

  • M. Khamforoush, O. Pirouzram, T. Hatami, Desalination 359, 14 (2015)

    Article  Google Scholar 

  • H. Khoshmohabat, S. Paydar, A. Makarem, M.Y. Karami, N. Dastgheib, S.A.H. Zahraei, R. Rezaei, G. Sadat, M. Nezhad, Open Access. Emerg. Med. 11, 171 (2019)

    Google Scholar 

  • S. S. Kordestani, in Atlas of Wound Healing (Elsevier, 2019), pp. 11–22

  • A.J. Kuijpers, G.H.M. Engbers, J. Feijen, S.C. De Smedt, T.K.L. Meyvis, J. Demeester, J. Krijgsveld, S.A.J. Zaat, J. Dankert, Macromolecules 32, 3325 (1999)

    Article  Google Scholar 

  • K. Leppänen, S. Andersson, M. Torkkeli, M. Knaapila, N. Kotelnikova, R. Serimaa, Cellulose 16, 999 (2009)

    Article  Google Scholar 

  • J. Leppiniemi, P. Lahtinen, A. Paajanen, R. Mahlberg, S. Metsä-Kortelainen, T. Pinomaa, H. Pajari, I. Vikholm-Lundin, P. Pursula, V.P. Hytönen, A.C.S. Appl, Mater. Interfaces 9, 21959 (2017)

    Article  Google Scholar 

  • A.C.W. Leung, S. Hrapovic, E. Lam, Y. Liu, K.B. Male, K.A. Mahmoud, J.H.T. Luong, Small 7, 302 (2011)

    Article  Google Scholar 

  • W. Li, R. Guo, Y. Lan, Y. Zhang, W. Xue, Y. Zhang, J. Biomed. Mater. Res. Part A 102, 1131 (2014)

    Article  Google Scholar 

  • N. Lin, J. Huang, P.R. Chang, L. Feng, J. Yu, Coll. Surf. B Biointerfaces 85, 270 (2011)

    Article  Google Scholar 

  • L.Z. Linan, A.C.M. Cidreira, C.Q. da Rocha, F.F. de Menezes, G.J. de M. Rocha, A.E.M. Paiva, J. Bioresour. Bioprod. 1 (2021). https://doi.org/10.1016/j.jobab.2021.04.007

  • J. Liu, S. Willför, A. Mihranyan, Carbohydr. Polym. 172, 11 (2017)

    Article  Google Scholar 

  • R. Liu, L. Dai, C. Si, Z. Zeng, Carbohydr. Polym. 195, 63 (2018)

    Article  Google Scholar 

  • W. Liu, H. Du, H. Liu, H. Xie, T. Xu, X. Zhao, Y. Liu, X. Zhang, C. Si, A.C.S. Sustain, Chem. Eng. 8, 16691 (2020)

    Google Scholar 

  • E. Lizundia, D. Puglia, T.D. Nguyen, I. Armentano, Prog. Mater. Sci. 112, 100668 (2020)

    Article  Google Scholar 

  • E.P.C.G. Luz, P.H.S. Chaves, L.A.P. de Vieira, S.F. Ribeiro, M.F. Borges, F.K. Andrade, C.R. Muniz, A.I. Molina, E.R. Castellón, M.F. de Rosa, R.S. Vieira, Carbohydr. Polym. 237, 116174 (2020)

    Article  Google Scholar 

  • B. Martina, K. Kateřina, R. Miloslava, G. Jan, M. Ruta, Adv. Polym. Technol. 28, 199 (2009)

    Article  Google Scholar 

  • E. Mascheroni, R. Rampazzo, M.A. Ortenzi, G. Piva, S. Bonetti, L. Piergiovanni, Cellulose 23, 779 (2016)

    Article  Google Scholar 

  • E. Masci, G. Faillace, M. Longoni, B.M.C. Res, Notes 11, 3 (2018)

    Google Scholar 

  • S. Megelski, J.S. Stephens, D. Bruce Chase, J.F. Rabolt, Macromolecules 35, 8456 (2002)

    Article  Google Scholar 

  • S. Meschini, E. Pellegrini, C.A. Maestri, M. Condello, P. Bettotti, G. Condello, M. Scarpa, J. Biomed. Mater. Res. Part B Appl. Biomater. 108, 687 (2020)

    Article  Google Scholar 

  • A. Mihranyan, J. Appl. Polym. Sci. 119, 2449 (2010)

    Article  Google Scholar 

  • K. Missoum, M.N. Belgacem, J. Bras, Materials (basel) 6, 1745 (2013)

    Article  Google Scholar 

  • A. Moeini, P. Pedram, P. Makvandi, M. Malinconico, G. Gomez dAyala, Carbohydr. Polym. 233, 115839 (2020)

    Article  Google Scholar 

  • T.C. Mokhena, M.J. John, Cellulose 27, 1149 (2020)

    Article  Google Scholar 

  • M. Monfared, D. Mawad, J. Rnjak-Kovacina, and M. H. Stenzel, J. Mater. Chem. B. 9, 6163–6175 (2021)

  • S. Montanari, M. Roumani, L. Heux, M.R. Vignon, Macromolecules 38, 1665 (2005)

    Article  Google Scholar 

  • J. Moohan, S. A. Stewart, E. Espinosa, A. Rosal, A. Rodríguez, E. Larrañeta, R. F. Donnelly, and J. Domínguez-Robles, Appl. Sci. 10 (2020)

  • R. J. Moon, A. Martini, J. Nairn, J. Simonsen, and J. Youngblood, Cellulose Nanomaterials Review: Structure, Properties and Nanocomposites (2011)

  • S. Mueller, J. Sapkota, A. Nicharat, T. Zimmermann, P. Tingaut, C. Weder, E.J. Foster, J. Appl. Polym. Sci. 132, 1 (2015)

    Article  Google Scholar 

  • S.V. Murphy, A. Atala, Nat. Biotechnol. 32, 773 (2014)

    Article  Google Scholar 

  • K. J. Nagarajan, N. R. Ramanujam, M. R. Sanjay, S. Siengchin, B. S. Rajan, K. S. Basha, P. Madhu, and G. R. Raghav, Polym. Compos. 1, 1588–1630 (2021)

  • P. Nakielski, F. Pierini, Acta Biomater. 84, 63 (2019)

    Article  Google Scholar 

  • Nanocellulose Mark. Prod. an Pricing Rep. 2019 (2019)

  • S. Napavichayanun, R. Yamdech, P. Aramwit, Arch. Dermatol. Res. 308, 123 (2016)

    Article  Google Scholar 

  • D.M.D. Nascimento, J.S. Almeida, M.S. do Vale, R.C. Leitão, C.R. Muniz, M.C.B.D. Figueirêdo, J.P.S. Morais, M.F. de Rosa, Ind. Crops Prod. 93, 66 (2016)

    Article  Google Scholar 

  • N. Naseri, A.P. Mathew, L. Girandon, M. Frohlich, K. Oksman, Cellulose 22, 521 (2015)

    Article  Google Scholar 

  • T.T. Nge, S.H. Lee, T. Endo, Cellulose 20, 1841 (2013)

    Article  Google Scholar 

  • L.P. Novo, J. Bras, A. García, N. Belgacem, A.A.S. Curvelo, A.C.S. Sustain, Chem. Eng. 3, 2839 (2015)

    Google Scholar 

  • L.P. Novo, J. Bras, A. García, N. Belgacem, A.A.S. da Curvelo, Ind. Crops Prod. 93, 88 (2016)

    Article  Google Scholar 

  • F.J. O’Brien, B.A. Harley, I.V. Yannas, L. Gibson, Biomaterials 25, 1077 (2004)

    Article  Google Scholar 

  • S. Ohta, T. Nishiyama, M. Sakoda, K. Machioka, M. Fuke, S. Ichimura, F. Inagaki, A. Shimizu, K. Hasegawa, N. Kokudo, M. Kaneko, Y. Yatomi, T. Ito, J. Biosci. Bioeng. 119, 718 (2015)

    Article  Google Scholar 

  • K. Oksman, Y. Aitomäki, A.P. Mathew, G. Siqueira, Q. Zhou, S. Butylina, S. Tanpichai, X. Zhou, S. Hooshmand, Compos. Part A Appl. Sci. Manuf. 83, 2 (2016)

    Article  Google Scholar 

  • F. Ostadhossein, N. Mahmoudi, G. Morales-Cid, E. Tamjid, F.J. Navas-Martos, B. Soriano-Cuadrado, J.M.L. Paniza, A. Simchi, Materials (basel) 8, 6401 (2015)

    Article  Google Scholar 

  • A.A. Oun, J.W. Rhim, Carbohydr. Polym. 150, 187 (2016)

    Article  Google Scholar 

  • J. Oyama, Á.C. Fernandes Herculano Ramos-Milaré, D.S.S. Lopes Lera-Nonose, V. Nesi-Reis, I. Galhardo Demarchi, S.M. Alessi Aristides, J. Juarez Vieira Teixeira, T. Gomes Verzignassi Silveira, M.V. Campana Lonardoni, Photodiagn. Photodyn. Ther. 30, 101682 (2020)

    Article  Google Scholar 

  • N. Pal, P. Dubey, P. Gopinath, K. Pal, Int. J. Biol. Macromol. 95, 94 (2017)

    Article  Google Scholar 

  • B. Pereira, V. Arantes, Ind. Crops Prod. 152, 112377 (2020)

    Article  Google Scholar 

  • P.H.F. Pereira, H.O.J. Luiz, L.V. Coutinho, B. Duchemin, M.O.H. Cioffi, Cellulose 27, 5745 (2020)

    Article  Google Scholar 

  • Y. Pilehvar-Soltanahmadi, M. Dadashpour, A. Mohajeri, A. Fattahi, R. Sheervalilou, N. Zarghami, Mini-Reviews. Med. Chem. 18, 414 (2018)

    Google Scholar 

  • G.N. Piozzi, E. Reitano, V. Panizzo, B. Rubino, D. Bona, D. Tringali, G. Micheletto, Am. J. Case Rep. 19, 812 (2018)

    Article  Google Scholar 

  • R. Poonguzhali, S.K. Basha, V.S. Kumari, Int. J. Biol. Macromol. 112, 1300 (2018)

    Article  Google Scholar 

  • M. Rajinipriya, M. Nagalakshmaiah, M. Robert, S. Elkoun, A.C.S. Sustain, Chem. Eng. 6, 2807 (2018)

    Google Scholar 

  • A. Rees, L.C. Powell, G. Chinga-Carrasco, D.T. Gethin, K. Syverud, K.E. Hill, D.W. Thomas, Biomed Res. Int. 2015, 1–7 (2015)

    Article  Google Scholar 

  • R. Reshmy, E. Philip, S. A. Paul, A. Madhavan, R. Sindhu, P. Binod, A. Pandey, and R. Sirohi, Rev. Environ. Sci. Bio/Technology (2020)

  • N. Rhein-Knudsen, M.T. Ale, A.S. Meyer, Mar. Drugs 13, 3340 (2015)

    Article  Google Scholar 

  • A.P.H. Rodrigues, S.D. de Souza, C.S.B. Gil, F.V. Pereira, L.C.A. de Oliveira, P.S. de Oliveira Patricio, J. Appl. Polym. Sci. 134, 16 (2017)

    Google Scholar 

  • A. Rogina, Appl. Surf. Sci. 296, 221 (2014)

    Article  Google Scholar 

  • R. Rohaizu, W.D. Wanrosli, Ultrason. Sonochem. 34, 631 (2017)

    Article  Google Scholar 

  • T. Saito, I. Shibata, A. Isogai, N. Suguri, N. Sumikawa, Carbohydr. Polym. 61, 414 (2005)

    Article  Google Scholar 

  • T. Saito, Y. Okita, T.T. Nge, J. Sugiyama, A. Isogai, Carbohydr. Polym. 65, 435 (2006)

    Article  Google Scholar 

  • A. Sbiai, H. Kaddami, H. Sautereau, A. Maazouz, E. Fleury, Carbohydr. Polym. 86, 1445 (2011)

    Article  Google Scholar 

  • F.T. Seta, X. An, L. Liu, H. Zhang, J. Yang, W. Zhang, S. Nie, S. Yao, H. Cao, Q. Xu, Y. Bu, H. Liu, Carbohydr. Polym. 234, 115942 (2020)

    Article  Google Scholar 

  • U.A. Sezer, İ Sahin, B. Aru, H. Olmez, G.Y. Demirel, S. Sezer, Carbohydr. Polym. 219, 87 (2019)

    Article  Google Scholar 

  • J. Shojaeiarani, D. Bajwa, A. Shirzadifar, Carbohydr. Polym. 216, 247 (2019)

    Article  Google Scholar 

  • R. Singla, S. Soni, P.M. Kulurkar, A. Kumari, S. Mahesh, V. Patial, Y.S. Padwad, S.K. Yadav, Carbohydr. Polym. 155, 152 (2017a)

    Article  Google Scholar 

  • R. Singla, S. Soni, V. Patial, P.M. Kulurkar, A. Kumari, S. Mahesh, Y.S. Padwad, S.K. Yadav, Int. J. Biol. Macromol. 105, 45 (2017b)

    Article  Google Scholar 

  • R. Singla, S. Soni, V. Patial, P.M. Kulurkar, A. Kumari, S. Mahesh, Y.S. Padwad, S.K. Yadav, Sci. Rep. 7, 1 (2017c)

    Article  Google Scholar 

  • P. Slezak, X. Monforte, J. Ferguson, S. Sutalo, H. Redl, H. Gulle, D. Spazierer, J. Mater. Sci. Mater. Med. 71, 1 (2018)

    Google Scholar 

  • M. Smyth, A. García, C. Rader, E.J. Foster, J. Bras, Ind. Crops Prod. 108, 257 (2017)

    Article  Google Scholar 

  • P. Sukyai, P. Anongjanya, N. Bunyahwuthakul, K. Kongsin, N. Harnkarnsujarit, U. Sukatta, R. Sothornvit, R. Chollakup, Food Res. Int. 107, 528 (2018)

    Article  Google Scholar 

  • M. Tavakolian, S.M. Jafari, T.G.M. Van De Ven, Nano-Micro Lett. 73, 23 (2020)

    Google Scholar 

  • H.L. Teo, R.A. Wahab, Int. J. Biol. Macromol. 161, 1414 (2020)

    Article  Google Scholar 

  • P. Thomas, T. Duolikun, N.P. Rumjit, S. Moosavi, C.W. Lai, M.R. Bin Johan, L.B. Fen, J. Mech. Behav. Biomed. Mater. 110, 103884 (2020)

    Article  Google Scholar 

  • W.Y. Tong, A.Y.K. Bin Abdullah, N.A.S. Binti Rozman, M.I.A. Bin Wahid, M.S. Hossain, L.C. Ring, Y. Lazim, W.N. Tan, Cellulose 25, 631 (2018)

    Article  Google Scholar 

  • D. Trache, M.H. Hussin, M.K.M. Haafiz, V.K. Thakur, Nanoscale 9, 1763 (2017)

    Article  Google Scholar 

  • J.P.C. Trigueiro, G.G. Silva, F.V. Pereira, R.L. Lavall, J. Colloid Interface Sci. 432, 214 (2014)

    Article  Google Scholar 

  • B.D. Ulery, L.S. Nair, C.T. Laurencin, J. Polym. Sci. Part B Polym. Phys. 49, 832 (2011)

    Article  Google Scholar 

  • O.M. Vanderfleet, D.A. Osorio, E.D. Cranston, Philos. Trans. A 376, 20170041 (2018)

    Article  Google Scholar 

  • K. Varaprasad, T. Jayaramudu, V. Kanikireddy, C. Toro, E.R. Sadiku, Carbohydr. Polym. 236, 116025 (2020)

    Article  Google Scholar 

  • N.F. Vasconcelos, J.P.A. Feitosa, F.M.P. da Gama, J.P.S. Morais, F.K. Andrade, M.S.M. de Souza Filho, M.F. de Rosa, Carbohydr. Polym. 155, 425 (2017)

    Article  Google Scholar 

  • C. Ventura, F. Pinto, A. F. Lourenço, P. J. T. Ferreira, H. Louro, and M. J. Silva, On the Toxicity of Cellulose Nanocrystals and Nanofibrils in Animal and Cellular Models (2020)

  • T. Wang, Q. Gu, J. Zhao, J. Mei, M. Shao, Y. Pan, J. Zhang, H. Wu, Z. Zhang, F. Liu, Int. J. Clin. Exp. Pathol. 8, 6636 (2015)

    Google Scholar 

  • B. Wang, X. Lv, S. Chen, Z. Li, X. Sun, C. Feng, H. Wang, Y. Xu, Cellulose 23, 3187 (2016)

    Article  Google Scholar 

  • T. Wang, Y. Zheng, Y. Shi, L. Zhao, Drug Deliv. Transl. Res. 9, 227 (2019)

    Article  Google Scholar 

  • J. Wei, B. Wang, Z. Li, Z. Wu, M. Zhang, N. Sheng, Q. Liang, H. Wang, S. Chen, Carbohydr. Polym. 238, 116207 (2020)

    Article  Google Scholar 

  • H. Wu, G.R. Williams, J. Wu, J. Wu, S. Niu, H. Li, H. Wang, L. Zhu, Carbohydr. Polym. 180, 304 (2018a)

    Article  Google Scholar 

  • Y. Wu, F. Wang, Y. Huang, Clin. Appl. Thromb. 24, 566 (2018b)

    Article  Google Scholar 

  • Q. Xiang, Y.Y. Lee, P.O. Pettersson, R.W. Torget, Appl. Biochem. Biotechnol. 105, 505 (2003)

    Article  Google Scholar 

  • J. Xiang, L. Shen, Y. Hong, Eur. Polym. J. 130, 109609 (2020)

    Article  Google Scholar 

  • X. Yang, W. Liu, N. Li, M. Wang, B. Liang, I. Ullah, A. Luis Neve, Y. Feng, H. Chen, C. Shi, Biomater. Sci. 5, 2357 (2017)

    Article  Google Scholar 

  • F. Yin, L. Lin, S. Zhan, J. Biomater. Sci. Polym. Ed. 30, 190 (2019)

    Article  Google Scholar 

  • M. Younas, A. Noreen, A. Sharif, A. Majeed, A. Hassan, S. Tabasum, A. Mohammadi, K.M. Zia, Int. J. Biol. Macromol. 124, 591 (2019)

    Article  Google Scholar 

  • H. Yuan, L. Chen, F.F. Hong, A.C.S. Appl, Mater. Interfaces 12, 3382 (2020)

    Article  Google Scholar 

  • K. Zhang, P. Sun, H. Liu, S. Shang, J. Song, D. Wang, Carbohydr. Polym. 138, 237 (2016)

    Article  Google Scholar 

  • S. Zhang, J. Li, S. Chen, X. Zhang, J. Ma, J. He, Carbohydr. Polym. 230, 115585 (2020)

    Article  Google Scholar 

  • J. Zhao, S. Li, Y. Zhao, Z. Peng, Polym. Bull. 77, 4401 (2020)

    Article  Google Scholar 

  • Y. Zhou, T. Saito, L. Bergström, A. Isogai, Biomacromol 19, 633 (2018)

    Article  Google Scholar 

  • K. Zubik, P. Singhsa, Y. Wang, H. Manuspiya, R. Narain, Polymers (basel) 9, 119 (2017)

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the funding received CNPq (130508/2020-9) and Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP (Project No. 2018/18722-6).

Author information

Authors and Affiliations

  1. Department of Material Engineering and Bioprocesses, University of Campinas (UNICAMP), School of Chemical Engineering (FEQ), University City Zeferino Vaz, Campinas, SP, CEP 13083-970, Brazil

    Anne Carolyne Mendonça Cidreira, Karine Cappuccio de Castro, Tahmasb Hatami & Lucia Helena Innocentini Mei

  2. Laboratory of Materials and Process Engineering (LaMEP), Chemical Engineering Department (DEEQ), Federal University of Maranhão (UFMA), Av. dos Portugueses, 1933, Bacanga, São Luís, MA, CEP 65080-805, Brazil

    Lamia Zuniga Linan

Authors
  1. Anne Carolyne Mendonça Cidreira
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karine Cappuccio de Castro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tahmasb Hatami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lamia Zuniga Linan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lucia Helena Innocentini Mei
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All the authors contributed to the study conception and design. Idea for the article: LHIM and ACMC. Literature research and data analysis: ACMC and KCdC. Figure design: TH, ACMC, KCdC. Critically revised the work: LZL, TH and LHIM. The authors have no relevant financial or non-financial interests to disclose.

Corresponding author

Correspondence to Anne Carolyne Mendonça Cidreira.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cidreira, A.C.M., de Castro, K.C., Hatami, T. et al. Cellulose nanocrystals-based materials as hemostatic agents for wound dressings: a review. Biomed Microdevices 23, 43 (2021). https://doi.org/10.1007/s10544-021-00581-0

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10544-021-00581-0

Keywords

Search

Navigation