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An overview on the exponential growth of non-invasive diagnosis of diabetes mellitus from exhaled breath by nanostructured metal oxide Chemi-resistive gas sensors and μ-preconcentrator

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Abstract

The characterization of acetone in exhaled breath reflects the internal metabolism of glucose in bloodstream and airways. This phenomenon provides a great potential for non-invasive diagnosis of diabetes mellitus and has inspired medical sodalities as an alternative diagnostic tool. This review discusses about the origination of acetone in breath, its correlation with blood glucose level along with the ways to collect breath sample. Furthermore, we also discuss the detection of acetone by chemical sensors with emphasis on the use of pre-concentrators on a single lab-on-chip for the diagnosis of diabetes mellitus. Finally, this review outlines the future directions for the detection of acetone from exhaled breath. The first part of the review introduces the biochemistry and prevalence of diabetes in India along with the existing techniques to estimate the concentration of acetone. The second part focuses on the semiconducting metal oxide and polymer gas sensors which discusses about tailoring the dynamic sensitivity range and selectivity towards acetone in breath. The third part elaborates on the ways to pre-concentrate the target biomarkers along with future perspectives for non-invasive diabetes diagnosis. Finally we also provide the perspectives on future challenges to make it to clinical practice.

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References

  • H. Ahn, Y. Wang, S.H. Jee, M. Park, Y.S. Yoon, D.J. Kim, Chem. Phys. Lett. 511, 331 (2011)

    Article  Google Scholar 

  • M. Alexiadou, M. Kandyla, G. Mousdis, M. Kompitsas, Appl. Phys. A 123, 262 (2017)

    Article  Google Scholar 

  • J.C. Anderson, Obesity 23, 2327 (2015)

    Article  Google Scholar 

  • J.C. Anderson, W.J.E. Lamm, M.P. Hlastala, J. Appl. Physiol. 100, 880 (2006)

    Article  Google Scholar 

  • Biomarkers Definitions Working Group Clinical Pharmacology & Therapeutics 69 89–95 (2001)

  • T.A. Betts, C.A. Tipple, M.J. Sepaniak, P.G. Datskos, Anal. Chim. Acta 422, 89 (2000)

    Article  Google Scholar 

  • T.P. Burg, M. Godin, S.M. Knudsen, W. Shen, G. Carlson, J.S. Foster, K. Babcock, S.R. Manalis, Nature 446, 1066 (2007)

    Article  Google Scholar 

  • S. Chakraborty, D. Banerjee, I. Ray, A. Sen, Curr. Sci. 94, 237 (2008)

    Google Scholar 

  • T.Y. Chen, M.J. Li, J.L. Wang, J. Chromatogr. A 976, 39 (2002)

    Article  Google Scholar 

  • X. Cheng, Y. Xu, S. Gao, H. Zhao, L. Huo, Sensors Actuators B 155, 716 (2011)

    Article  Google Scholar 

  • S.M. Cho, Y.J. Kim, G.S. Heo, S.M. Shin, Sensors Actuators B Chem. 117, 50 (2006)

    Article  Google Scholar 

  • S.J. Choi, B.H. Jang, S.J. Lee, B.K. Min, A. Rothschild, I.D. Kim, Appl. Mater. Interfaces 6, 2588 (2014)

    Article  Google Scholar 

  • X. Chu, P. Dai, S. Liang, A. Bhattacharya, Y. Dong, M. Epifani, Physica E Low Dimens Syst Nanostruct 106, 326 (2019)

    Article  Google Scholar 

  • P.K. Chuang, L.C. Wang, C.T. Kuo, Thin Solid Films 529, 205 (2013)

    Article  Google Scholar 

  • A. Daneshkhah, S. Shrestha, M. Agarwal, K. Varahramyan, Sensors Actuators B 221, 635 (2015)

    Article  Google Scholar 

  • S. Das, S. Pal, M. Mitra, J. Med. Biol. Eng. 36(605) (2016)

  • C. Deng, J. Zhang, X. Yu, W. Zhang, X. Zhang, J. Chromatogr. B 810, 269 (2004)

    Article  Google Scholar 

  • M. Ding, D.C. Sorescu, A. Star, J. Am. Chem. Soc. 135, 9015 (2013)

    Article  Google Scholar 

  • J.S. Do, S.H. Wang, Sensors Actuators B 185, 39 (2013)

    Article  Google Scholar 

  • Y. Dong, W. Gao, Q. Zhou, Y. Zheng, Z. You, Anal. Chim. Acta 671, 85 (2010)

    Article  Google Scholar 

  • Executive Summary of India Council of Medical Research Youth Diabetes Registry Phase – 1 Report http://icmr.nic.in/final/diabetes/Executive%20summary%20YDR%2025082014.pdf

  • L. Fadel, F. Lochon, I. Dufour, O. Francais, J. Micromech. Microeng. 14, 23 (2004)

    Article  Google Scholar 

  • N. Fens, M.P. Van der Schee, P. Brinkman, P.J. Sterk, Clin. Exp. Allergy 43, 705 (2013)

    Article  Google Scholar 

  • I. Gracia, P. Ivanov, F. Blanco, N. Sabate, X. Vilanova, X. Correig, L. Fonseca, E. Figueras, J. Santander, C. Cane, Sensors Actuators B 132, 149 (2008)

    Article  Google Scholar 

  • A. Hasani, H.S. Dehsari, J.N. Gavgani, E.K. Shalamzari, A. Salehi, F.A. Taromi, M. Mahyari, Microchim. Acta 182, 1551 (2015)

    Article  Google Scholar 

  • J. Hu, Y. Wang, W. Wang, Y. Xue, P. Li, K. Lian, L. Chen, W. Zhang, S. Zhuiykov, J. Mater. Sci. 52, 11554 (2017)

    Article  Google Scholar 

  • Q.Q. Jia, H.M. Ji, P. Gao, X. Bai, Z.G. Jin, J. Mater. Sci. Mater. Electron. 26, 5792 (2015)

    Article  Google Scholar 

  • R. Kalidoss, S. Umapathy, R. Anandan, V. Ganesh, Y. Sivalingam, Anal. Chem. 91, 5116 (2019)

    Article  Google Scholar 

  • K.W. Kao, M.C. Hsu, Y.H. Chang, S. Gwo, J.A. Yeh, Sensors 12, 7157 (2012)

    Article  Google Scholar 

  • J. Kaur, K. Anand, K. Anand, R. C. Singh, J. Mater. Sci. 53 12894 (2018)

  • N. Kilinc, O. Cakmak, A. Kosemen, E. Ermek, S. Ozturk, Y. Yerli, Z.Z. Ozturk, H. Urey, Sensors Actuators B 202, 357 (2014)

    Article  Google Scholar 

  • J. King, P. Mochalski, A. Kupferthaler, K. Unterkofler, H. Koc, W. Filipiak, S. Teschl, H. Hinterhuber, A. Amann, Physiol. Meas. 31, 1169 (2010)

    Article  Google Scholar 

  • S. Kischkel, W. Miekisch, A. Sawacki, E.M. Straker, P. Trefz, A. Amann, J.K. Schubert, Clin. Chim. Acta 411, 1637 (2010)

    Article  Google Scholar 

  • J. Lee, M. Jung, S. Barthwal, S. Lee, S.H. Lim, Biochip J. 9, 44 (2014)

    Article  Google Scholar 

  • J.H. Leopold, R.T.M.V. Hooijdonk, P.J. Sterk, A.A. Hanna, M.J. Schultz, L.D. Bos, BMC Anesthesiol. 14, 46 (2014)

    Article  Google Scholar 

  • D. Lian, B. Shi, R. Dai, X. Jia, X. Wu, J. Nanopart. Res. 19, 401 (2017)

    Article  Google Scholar 

  • Y. Lin, H. Ji, Z. Shen, Q. Jia, D. Wang, J. Mater. Sci. Mater. Electron. 27, 2086 (2016)

    Article  Google Scholar 

  • Z. Liu, T. Yang, Y. Dong, X. Wang, Sensors 18, 3113 (2018)

    Article  Google Scholar 

  • C.J. Lu, E.T. Zellers, Anal. Chem. 73, 3449 (2001)

    Article  Google Scholar 

  • C.J. Lu, E.T. Zellers, Analyst 127, 1061 (2002)

    Article  Google Scholar 

  • D. Maity, K. Rajavel, R.T.R. Kumar, Sensors Actuators B 261, 297 (2018)

    Article  Google Scholar 

  • S. K. Mohapatra, S. K. Mahapatra, S. K. Tripathy, L. Kanoje In Proceedings of the First International Conference on Intelligent Computing and Communication. Advances in Intelligent Systems and Computing ed. by J. Mandal, S. Satapathy, M. Sanyal, V. Bhateja (Springer, Singapore, 2017), p. 17

  • M.E. O’Hara, T.H.C. Brock, S. Green, C.A. Mayhew, J. Breath Res. 3, 027005 (2009)

    Article  Google Scholar 

  • C. Peng, J. Guo, W. Yang, C. Shi, M. Liu, Y. Zheng, J. Xu, P. Chen, T. Huang, Y. Yang, J. Alloys Compd. 654, 371 (2016)

    Article  Google Scholar 

  • L. Peng, T.F. Xie, M. Yang, P. Wang, D. Xu, S. Pang, D.J. Wang, Sensors Actuators B 131, 660 (2008)

    Article  Google Scholar 

  • T. Pisarkiewicz, W. Maziarz, A. Rydosz, J. Mueller, M. Mach, Procedia Eng. 5, 1244 (2010)

    Article  Google Scholar 

  • A. Rydosz, J. Microelectr. Electr. Compon. Mater. 44, 126 (2014)

    Google Scholar 

  • A. Rydosz, W. Maziarz, T. Pisarkiewicz, K. Domański, P. Grabiec, Microelectron. Reliab. 52, 2640 (2012)

    Article  Google Scholar 

  • A. Rydosz, D. Michon, K. Domanski, W. Maziarz, T. Pisarkiewicz, Adv. Electr. Comput. En. 14, 59 (2016)

    Google Scholar 

  • S. Sachdeva, R. Agarwal, A. Agarwal, Microsyst. Technol. 1 (2018a)

  • S. Sachdeva, R. Agarwal, A. Agarwal, Bull. Mater. Sci. 41, 105 (2018b)

    Article  Google Scholar 

  • S. Salehi, E. Nikan, A.A. Khodadadi, Y. Mortazavi, Sensors Actuators B 205, 261 (2014)

    Article  Google Scholar 

  • J.H. Seo, S.K. Kim, E.T. Zellers, K. Kurabayashi, Lab Chip 12, 717 (2012)

    Article  Google Scholar 

  • N. Shiraishi, T. Ikehara, D.V. Dao, S. Sugiyama, Y. Ando, Sensors Actuators A 202, 233 (2013)

    Article  Google Scholar 

  • P. Si, J. Mortensen, A. Komolov, J. Denborg, P.J. Moller, Anal. Chim. Acta 597, 223 (2007)

    Article  Google Scholar 

  • D. Smith, P. Spanel, A.A. Fryer, F. Hanna, G.A.A. Ferns, J. Breath Res. 5, 022001 (2011)

    Article  Google Scholar 

  • C. Steffens, F.L. Leite, A. Manzoli, R.D. Sandoval, O. Fatibello, P.S.P. Herrmann, J. Nanosci. Nanotechnol. 14, 6718 (2014)

    Article  Google Scholar 

  • L. Sun, Z. Yao, A.A. Haidry, Z. Li, Q. Fatima, L. Xie, J. Mater. Sci. Mater. Electron. 29, 14546 (2018)

    Article  Google Scholar 

  • M. Sun, Z. Chen, Z. Gong, X. Zhao, C. Jiang, Y. Yuan, Z. Wang, Y. Li, C. Wang, Anal. Bioanal. Chem. 407, 1641 (2015)

    Article  Google Scholar 

  • C. Turner, C. Walton, S. Hoashi, M. Evans, J. Breath Res. 3, 046004 (2009)

    Article  Google Scholar 

  • I. Ueta, Y. Saito, M. Hosoe, M. Okamoto, H. Ohkita, S. Shirai, H. Tamura, K. Jinno, J. Chromatogr. B 877, 2551 (2009)

    Article  Google Scholar 

  • A. Vomiero, S. Bianchi, E. Comini, G. Faglia, M. Ferroni, G. Sberveglieri, Cryst. Growth Des. 7, 2500 (2007)

    Article  Google Scholar 

  • C. Wang, A.B. Surampudi, Meas. Sci. Technol. 19, 105604 (2008)

    Article  Google Scholar 

  • C. Wang, A. Mbi, M. Sheperd, IEEE Sensors J. 10, 54 (2010)

    Article  Google Scholar 

  • L. Wang, A. Teleki, S. Pratsinis, P. Gouma, Chem. Mater. 20, 4794 (2008)

    Article  Google Scholar 

  • Z. Wang, C. Wang, J. Breath Res. 7, 037109 (2013)

    Article  Google Scholar 

  • S. Wei, J. Zhao, W. Du, Ceram. Int. 41, 769 (2015)

    Article  Google Scholar 

  • M.Y. Wong, W.R. Cheng, M.H. Liu, W.C. Tian, C.J. Lu, Talanta 101, 307 (2012)

    Article  Google Scholar 

  • T. Xiao, X.Y. Wang, Z.H. Zhao, L. Li, L. Zhang, H.C. Yao, J.S. Wang, Z.J. Li, Sensors Actuators B 199, 210 (2014)

    Article  Google Scholar 

  • R. Xing, L. Xu, J. Song, C. Zhou, Q. Li, D. Liu, H.W. Song, Sci. Rep. 5, 10717 (2015)

    Article  Google Scholar 

  • D. Zhang, A. Liu, H. Chang, B. Xia, RSC Adv. 5, 3016 (2015)

    Article  Google Scholar 

  • M.G. Zhou, Y. Liu, W.W. Li, X. Yuan, X.F. Zhan, J. Li, Y.X. Duan, Y. Liu, Z.H. Gao, Y. Cheng, S.Q. Cheng, H. Li, Y. Liang, Chin. Sci. Bull. 59, 1992 (2014)

    Article  Google Scholar 

  • L. Zhu, W. Zeng, Sensors Actuators A (2017)

  • Y.A. Zolotov, J. Anal. Chem. 60, 497 (2005)

    Article  Google Scholar 

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Acknowledgments

The authors are thankful to the Department of Biomedical Engineering, SRM Institute of Science & Technology for encouraging the research and providing necessary financial assistance.

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  1. Department of Biomedical Engineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India

    Ramji Kalidoss & Snekhalatha Umapathy

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  1. Ramji Kalidoss
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Correspondence to Snekhalatha Umapathy.

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Kalidoss, R., Umapathy, S. An overview on the exponential growth of non-invasive diagnosis of diabetes mellitus from exhaled breath by nanostructured metal oxide Chemi-resistive gas sensors and μ-preconcentrator. Biomed Microdevices 22, 2 (2020). https://doi.org/10.1007/s10544-019-0448-z

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