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Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface

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Abstract

The cuff electrode provides a stable interface with peripheral nerves, which has been widely used in basic research and clinical practice. Currently, the cuff electrodes are limited by the planar processing of microfabrication. This paper presents a novel cuff electrode using high-aspect ratio carbon nanotubes (CNTs) integrated on a flexible biocompatible parylene. The microfabrication process unites the high quality vertical CNTs grown at high temperature with the heat sensitive parylene substrate in a highly controllable manner. The fabricated cuff electrodes have been utilized for extracellular nerve stimulation in rats. The experimental results demonstrate the proposed CNT electrode has a better performance than Pt electrode in nerve stimulation. Moreover, the effect of electrode position and stimulation frequency is demonstrated in this paper. This preliminary data indicates that flexible 3D CNTs cuff electrode provides an excellent platform for functional electrical stimulation.

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Acknowledgements

The device was fabricated using Nano Fabrication Core (nFab) at Wayne State University. This work was supported by National Science Foundation (NSF) CAREER Award (1055932), NSF MRI Award (1229635), National Natural Science Foundation of China (51775332, 51675329), Major Project of National Social Science Fund (17ZDA020), Shanghai Committee of Science and Technology (15142200800, 16441906000, 16XD1425000), National Key R&D Program of China (2016YFF0101602, 2016YFC0104104), the State Key Laboratory of Mechanical System and Vibration (MSV201601).

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Authors and Affiliations

  1. State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China

    Pan Tian, Jie Hu & Jin Qi

  2. Electrical and Computer Engineering, Wayne State University, Detroit, MI, USA

    Wenwen Yi, Boshen Zhang & Mark Ming-Cheng Cheng

  3. Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA

    Chaoyang Chen & Mark Ming-Cheng Cheng

Authors
  1. Pan Tian
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  2. Wenwen Yi
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  3. Chaoyang Chen
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  4. Jie Hu
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  5. Jin Qi
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  6. Boshen Zhang
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  7. Mark Ming-Cheng Cheng
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Corresponding authors

Correspondence to Jie Hu or Mark Ming-Cheng Cheng.

Additional information

Jie Hu and Mark Ming-Cheng Cheng’s groups contribute the work equally, and they are listed as co-corresponding authors.

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Tian, P., Yi, W., Chen, C. et al. Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface. Biomed Microdevices 20, 21 (2018). https://doi.org/10.1007/s10544-018-0268-6

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