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An investigation of vibration-induced protein desorption mechanism using a micromachined membrane and PZT plate

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Abstract

A micromachined vibrating membrane is used to remove adsorbed proteins on a surface. A lead zirconate titanate (PZT) composite (3 × 1 × 0.5 mm) is attached to a silicon membrane (2,000 × 500 × 3 μm) and vibrates in a flexural plate wave (FPW) mode with wavelength of 4,000/3 μm at a resonant frequency of 308 kHz. The surface charge on the membrane and fluid shear stress contribute in minimizing the protein adsorption on the SiO2 surface. In vitro characterization shows that 57 ± 10% of the adsorbed bovine serum albumin (BSA), 47 ± 13% of the immunoglobulin G (IgG), and 55.3~59.2 ± 8% of the proteins from blood plasma are effectively removed from the vibrating surface. A simulation study of the vibration-frequency spectrum and vibrating amplitude distribution matches well with the experimental data. Potentially, a microelectromechanical system (MEMS)-based vibrating membrane could be the tool to minimize biofouling of in vivo MEMS devices.

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Acknowledgement

This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC), Canada Foundation for Innovation (CFI). Dr. Chiao is supported by Canada Research Chair, Tier 2 program. J.N.K. is the recipient of a CBS/CIHR new investigator award in transfusion science.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, British Columbia, V6T 1Z4, Canada

    Po Ying Yeh & Mu Chiao

  2. Centre for Blood Research, Department of Pathology and Laboratory Medicine, University of British Columbia, 4th Floor, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, British Columbia, V6T 1Z3, Canada

    Yevgeniya Le & Jayachandran N. Kizhakkedathu

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  1. Po Ying Yeh
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  2. Yevgeniya Le
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  3. Jayachandran N. Kizhakkedathu
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  4. Mu Chiao
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Correspondence to Jayachandran N. Kizhakkedathu or Mu Chiao.

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Yeh, P.Y., Le, Y., Kizhakkedathu, J.N. et al. An investigation of vibration-induced protein desorption mechanism using a micromachined membrane and PZT plate. Biomed Microdevices 10, 701–708 (2008). https://doi.org/10.1007/s10544-008-9181-8

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