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Tylosin in anaerobic reactors: degradation kinetics, effects on methane production and on the microbial community

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Abstract

Tylosin eliminated in animal waste, during therapeutic treatment, can be efficiently removed in anaerobic systems. The present study investigated the influence of tylosin concentration and assessed its degradation kinetics and the microorganisms involved in each stage of its anaerobic digestion (hydrolysis/acidogenesis; acetogenesis; methanogenesis). The results showed a stimulating effect on methane production with increasing tylosin concentration in the poultry litter up to 80 mg kg−1 tylosin (232.9 NL CH4 kg SV−1). As for tylosin degradation, greater removal of antibiotics was observed in the methanogenic phase (88%), followed by acetogenic (84%) and hydrolytic/acidogenic (76%) phases. The higher rate of tylosin degradation obtained in the methanogenic step, is mainly related to the co-metabolic effect exerted by the presence of acetate and its degradation by acetoclastic methanogens. Indeed, metagenomic analyses suggested a syntrophic action between archaea of ​​the genus Methanobacterium, and bacteria such as Clostridium and Flexilinea, which seemed decisive for tylosin degradation.

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The authors declare that all data supporting the findings of this study are available within the article, including the supplementary information on files.

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Acknowledgements

The authors would like to thank the Coordination for the Improvement of Higher Education Personnel – CAPES (Funding Code nº 001) and the financial support received by the following agencies/institutes: National Health Foundation – FUNASA (2510001557612017-21); National Council for Scientific and Technological Development – CNPq (423101/2018-8 and 151883/2020-3); Research Support Foundation of the State of Minas Gerais – FAPEMIG (APQ-02701-18) and the Federal University of Ouro Preto – UFOP.

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AGOP: Conceptualization, Methodology, Investigation, Resources, Writing – Original Draft. ARP: Methodology, Formal analysis, Writing – Original Draft. YAF: Methodology, Formal analysis, Writing – Original Draft. SQS: Writing – Review & Editing, Visualization. SFA: Conceptualization, Writing - Review & Editing, Project administration, Funding acquisition.

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Correspondence to Sérgio Francisco de Aquino.

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Paranhos, A.G., Pereira, A.R., da Fonseca, Y.A. et al. Tylosin in anaerobic reactors: degradation kinetics, effects on methane production and on the microbial community. Biodegradation 33, 283–300 (2022). https://doi.org/10.1007/s10532-022-09980-3

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  • DOI: https://doi.org/10.1007/s10532-022-09980-3

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