Changes in the structure of the olfactory bulbs after long-term intranasal administration of pesticide rotenone, a classical inductor of parkinsonism, to rats were studied by the methods of immunomorphology. In rats intranasally receiving rotenone in a dose of 2.5 mg/kg every other day over 2 weeks, a decrease in the density of dopaminergic neurons and the area of astrocyte processes in the olfactory bulbs, activation of microglia in the glomerular layer, and enhanced α-synuclein phosphorylation and its accumulation in the bodies of mitral layer neurons were observed. The observed changes agree with the hypothesis on pathological α-synuclein transport via the olfactory route in Parkinson’s disease and confirm relevance of the rotenone model of Parkinson’s disease for studies of the pathological accumulation of α-synuclein.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 232-236, August, 2017
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Voronkov, D.N., Kutukova, K.A., Ivanov, M.V. et al. Immunomorphological Changes in the Olfactory Bulbs of Rats after Intranasal Administration of Rotenone. Bull Exp Biol Med 164, 203–206 (2017). https://doi.org/10.1007/s10517-017-3958-9
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DOI: https://doi.org/10.1007/s10517-017-3958-9