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A fully integrated 4-channel GMR biochip for biomedical detection applications

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Abstract

This paper proposed a fully integrated 4-channel GMR biochip for biomedical detection assays, including the acquisition analog frontend for small signal extraction, 180° phase shifter, resistor ladder and control circuits for carrier cancellation, and amplifiers. Besides, the overall system was evaluated comprehensively by experiment, and the output noise is as low as \(321.7\mathrm {nV/\sqrt{Hz}},\) which is lower than the signal produced by one single 500nm magnetic particle during the detection.

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Acknowledgements

The authors would like to thank Keysight Technologies for instruments and measurement supports. This work is supported by National Natural Science Foundation of China under Grant 61101001, 61204026 and 61674087, and Tsinghua University Initiative Scientific Research Program.

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Authors and Affiliations

  1. Institute of Microelectronics, Tsinghua University, Beijing, 100084, China

    Cheng Zhu, Lei Zhang & He Qian

  2. Dongguan Bosh Biotechnologies, LTD., Dongguan, China

    Xizeng Shi

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  1. Cheng Zhu
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  2. Lei Zhang
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  4. He Qian
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Correspondence to Lei Zhang.

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Zhu, C., Zhang, L., Shi, X. et al. A fully integrated 4-channel GMR biochip for biomedical detection applications. Analog Integr Circ Sig Process 95, 513–521 (2018). https://doi.org/10.1007/s10470-018-1154-0

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