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Association of HIV Infection with Epilepsy and Other Comorbid Conditions

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Abstract

Here, we aimed to investigate the associations of comorbidities in HIV patients given antiepileptic drugs. HIV patients given antiepileptic drugs for at least 6 months were considered. Comorbidities of the epileptic, HIV-positive patients were stratified according to patients’ age and causes of epilepsy. Seventy-four of the 97 HIV patients identified had at least one comorbidity. Patients more than 50-years old had more comorbidities (1.9 ± 1.5 vs. 1.1 ± 1.2, p < 0.01) compared with younger subjects. The distribution of the psychiatric disorders was comparable between age-related categories. A marginally significant trend for higher frequency of psychiatric disorders was observed in patients with idiopathic epilepsy versus other causes of epilepsy (43% vs. 24%), Because the presence of comorbid disorders is a major driver for premature mortality both in HIV infection and epilepsy, strategies aimed at favoring prevention, early identification, and adequate treatment in these clinical settings should be pursued at all levels of care.

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Acknowledgements

This is an independent, no profit study supported by intramural funding of the L. Sacco Hospital. The Authors have not received any compensation for the present paper. Not related to the present investigation, CG and GR have received educational grants from Merck Sharp & Dome, Janssen-Cilag, ViiV Healthcare, Bristol Myers Squibb, Boehringer Ingelheim, Gilead and Abbvie. DC has received educational grants from Merck Sharp & Dome and ViiV Healthcare.

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Authors and Affiliations

  1. Gestione Ambulatoriale Politerapie (GAP) Outpatient Clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

    Dario Cattaneo & Cristina Gervasoni

  2. Unit of Clinical Pharmacology, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

    Dario Cattaneo

  3. Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Via GB Grassi 74, 20157, Milan, Italy

    Andrea Giacomelli, Davide Minisci, Noemi Astuti, Paola Meraviglia & Cristina Gervasoni

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  1. Dario Cattaneo
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  2. Andrea Giacomelli
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  3. Davide Minisci
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  4. Noemi Astuti
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  5. Paola Meraviglia
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  6. Cristina Gervasoni
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Correspondence to Cristina Gervasoni.

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Cattaneo, D., Giacomelli, A., Minisci, D. et al. Association of HIV Infection with Epilepsy and Other Comorbid Conditions. AIDS Behav 24, 1051–1055 (2020). https://doi.org/10.1007/s10461-019-02530-8

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  • DOI: https://doi.org/10.1007/s10461-019-02530-8

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