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At-Risk Alcohol Use Among HIV-Positive Patients and the Completion of Patient-Reported Outcomes

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Abstract

Heavy drinking is prevalent among people living with HIV. Studies use tools like patient-reported outcomes (PROs) to quantify alcohol use in a detailed, timely manner. However, if alcohol misuse influences PRO completion, selection bias may result. Our study included 14,145 adult HIV patients (133,036 visits) from CNICS who were eligible to complete PROs at an HIV primary care visit. We compared PRO completion proportions between patients with and without a clinical diagnosis of at-risk alcohol use in the prior year. We accounted for confounding by baseline and visit-specific covariates. PROs were completed at 20.8% of assessed visits. The adjusted difference in PRO completion proportions was −3.2% (95% CI −5.6 to −0.8%). The small association between receipt of an at-risk alcohol use diagnosis and decreased PRO completion suggests there could be modest selection bias in studies using the PRO alcohol measure.

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Acknowledgements

This project was supported by Grant Numbers T32ES007018, R01AI100654, R24AI067039 and P30AI50410 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr. Stephen Cole and Dr. Jessie Edwards provided expert advice and consultation throughout the project process. The Center for AIDS Research Network of Integrated Clinical Systems supplied the data and information on the cohort and linked us to our CNICS collaborators, including Dr. Moore, Dr. O’Cleirigh, Dr. Christopoulos, and Dr. Mathews.

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Authors and Affiliations

  1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB# 7435, Chapel Hill, NC, 27599, USA

    Jacqueline E. Rudolph, Stephen R. Cole & Jessie K. Edwards

  2. Department of Medicine, Johns Hopkins University, Baltimore, MD, USA

    Richard Moore

  3. Harvard Medical School, Boston, MA, USA

    Conall O’Cleirigh

  4. Department of Medicine, University of California at San Diego, San Diego, CA, USA

    Wm. Christopher Mathews

  5. Department of Medicine, University of California at San Francisco, San Francisco, CA, USA

    Katerina Christopoulos

Authors
  1. Jacqueline E. Rudolph
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  2. Stephen R. Cole
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  3. Jessie K. Edwards
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  4. Richard Moore
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  5. Conall O’Cleirigh
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  6. Wm. Christopher Mathews
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  7. Katerina Christopoulos
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For the Center for AIDS Research Network of Integrated Clinical Systems

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Correspondence to Jacqueline E. Rudolph.

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All authors declare that they have no conflicts of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors. This study was reviewed by the Office of Human Research Ethics at the University of North Carolina at Chapel Hill and was determined to not constitute human subjects research as defined under federal regulations.

Appendix

Appendix

See Tables 6 and 7.

Table 6 Baseline characteristics of CNICS patients at first eligible visit and all eligible visits
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Table 7 Visit-specific characteristics of CNICS patients at first eligible visit and all eligible visits
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Rudolph, J.E., Cole, S.R., Edwards, J.K. et al. At-Risk Alcohol Use Among HIV-Positive Patients and the Completion of Patient-Reported Outcomes. AIDS Behav 22, 1313–1322 (2018). https://doi.org/10.1007/s10461-017-1824-4

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  • DOI: https://doi.org/10.1007/s10461-017-1824-4

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