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Influence of Side Effects on ART Adherence Among PLWH in China: The Moderator Role of ART-Related Knowledge

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Abstract

Despite the medical advancements in HIV treatment, realities of side effects are faced by people living with HIV (PLWH) who receive antiretroviral therapy (ART). Mixed findings have been reported on the association between side effects and ART adherence. However, few studies have explored the combined side effects and behavior-related information on medication adherence. The aim of the current study is to examine moderator role of ART-related knowledge between side effects and ART adherence. A cross-sectional survey was conducted among 2987 PLWH from October 2012 to August 2013 in China. Of the total sample, 2095 patients had received ART and provided ART adherence. Side effects, ART-related knowledge, and ART adherence, as well as potential covariates were assessed. The results revealed that there was a negative relationship of side effects and ART adherence existed among low and medium levels of ART-related knowledge, but not among high level of knowledge. Future interventions to promote HIV medication adherence should focus on providing behavior-related information education among PLWH.

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Acknowledgements

The authors want to thank other team members at University of South Carolina and Guangxi CDC for their efforts in instrument development and data collection and data management. The authors wish to thank Dr. Christine Beyer, Director of Community Engagement, for her contributions to language edition.

Funding

The study was supported by National Institutes of Health (NIH) [Grant Nos. R01HD074221 and R01AA018090] and National Nature Science Foundation of China (NSFC) [Grant No. 71673146]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or NSFC.

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Authors and Affiliations

  1. Department of Health Promotion, Education, and Behavior & South Carolina SmartState Center for Healthcare Quality (CHQ), University of South Carolina Arnold School of Public Health, 915 Greene Street, Columbia, SC, 29208, USA

    Guangyu Zhou, Xiaoming Li & Shan Qiao

  2. Guangxi Center for Disease Control and Prevention, Nanning, People’s Republic of China

    Zhiyong Shen & Yuejiao Zhou

  3. School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, People’s Republic of China

    Guangyu Zhou

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  1. Guangyu Zhou
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Correspondence to Guangyu Zhou.

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Conflict of interest

Guangyu Zhou declares that he has no conflict of interest. Xiaoming Li declares that he has no conflict of interest. Guangyu Zhou declares that he has no conflict of interest. Shan Qiao declares that she has no conflict of interest. Zhiyong Shen declares that he has no conflict of interest. Yuejiao Zhou declares that she has no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

Additional information

Joint first authors: Guangyu Zhou and Yuejiao Zhou.

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Zhou, G., Li, X., Qiao, S. et al. Influence of Side Effects on ART Adherence Among PLWH in China: The Moderator Role of ART-Related Knowledge. AIDS Behav 22, 961–970 (2018). https://doi.org/10.1007/s10461-017-1791-9

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  • DOI: https://doi.org/10.1007/s10461-017-1791-9

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