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Fractured Symmetries: Information and Control Theory Perspectives on Mitochondrial Dysfunction

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...[E]stimation of mutual information and channel capacity [of cellular signals] from experimental data is a nontrivial challenge.

— Suderman et al. (2017)

Abstract

Mitochondrial dysfunction underlies a vast array of chronic disorders across the life span. The asymptotic limit theorems of information and control theories, supplemented by symmetry-breaking phase transition arguments adapted from physical theory, give deep insight into canonical mechanisms of cognition and regulation associated with such dysfunction. The probability models studied here can provide a foundation for the development of statistical tools useful in clinical and public health address of those disorders.

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Acknowledgements

The author thanks Dr. D.N. Wallace—an actual biologist—for useful comments and suggestions, and the editor and reviewers for perceptive insights and hard work.

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  1. The New York State Psychiatric Institute, New York, USA

    Rodrick Wallace

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  1. Rodrick Wallace
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Correspondence to Rodrick Wallace.

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Wallace, R. Fractured Symmetries: Information and Control Theory Perspectives on Mitochondrial Dysfunction. Acta Biotheor 69, 277–301 (2021). https://doi.org/10.1007/s10441-020-09387-8

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