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3D Bioprinting of Hyaline Cartilage Using Nasal Chondrocytes

  • S.I. : Bioengineering and Enabling Technologies II
  • Published:
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Abstract

Due to the limited self-repair capacity of the hyaline cartilage, the repair of cartilage remains an unsolved clinical problem. Tissue engineering strategy with 3D bioprinting technique has emerged a new insight by providing patient’s personalized cartilage grafts using autologous cells for hyaline cartilage repair and regeneration. In this review, we first summarized the intrinsic property of hyaline cartilage in both maxillofacial and orthopedic regions to establish the requirement for 3D bioprinting cartilage tissue. We then reviewed the literature and provided opinion pieces on the selection of bioprinters, bioink materials, and cell sources. This review aims to identify the current challenges for hyaline cartilage bioprinting and the directions for future clinical development in bioprinted hyaline cartilage.

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Funding

Funding was provided by Natural Sciences and Engineering Research Council of Canada (NSERC RGPIN 06431), Canadian Institutes of Health Research (CIHR PS 159661), and Alberta Cancer Foundation (ACF-MIBRP 27128).

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  1. Department of Civil and Environmental Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada

    Xiaoyi Lan & Yaman Boluk

  2. Department of Surgery, Divisions of Orthopedic Surgery & Surgical Research, Faculty of Medicine & Dentistry, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, Canada

    Adetola B. Adesida

  3. Department of Surgery, Division of Otolaryngology, Faculty of Medicine & Dentistry, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, Canada

    Adetola B. Adesida

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Lan, X., Boluk, Y. & Adesida, A.B. 3D Bioprinting of Hyaline Cartilage Using Nasal Chondrocytes. Ann Biomed Eng (2023). https://doi.org/10.1007/s10439-023-03176-3

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