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Material Processing and Design of Biodegradable Metal Matrix Composites for Biomedical Applications

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Abstract

In recent years, biodegradable metallic materials have played an important role in biomedical applications. However, as typical for the metal materials, their structure, general properties, preparation technology and biocompatibility are hard to change. Furthermore, biodegradable metals are susceptible to excessive degradation and subsequent disruption of their mechanical integrity; this phenomenon limits the utility of these biomaterials. Therefore, the use of degradable metals, as the base material to prepare metal matrix composite materials, it is an excellent alternative to solve the problems above described. Biodegradable metals can thus be successfully combined with other materials to form biodegradable metallic matrix composites for biomedical applications and functions. The present article describes the processing methods currently available to design biodegradable metal matrix composites for biomedical applications and provides an overview of the current existing biodegradable metal systems. At the end, the manuscript presents and discusses the challenges and future research directions for development of biodegradable metallic matrix composites for biomedical purposes.

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Acknowledgments

This work was supported by the 2017 Premium Funding Project for Academic Human Resources Development at Beijing Union University (Grant No. BPHR2017DZ09), the 2017 Quota-Oriented Project for Improvement of Scientific Research at Beijing Union University (Grant No. KYDE40201708), and the National Institute of Health of the United States (Grant No. R01 AR068073, R01 CA180279, and P41 EB023833).

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Authors and Affiliations

  1. Beijing Engineering Research Center of Smart Mechanical Innovation Design Service, Beijing, People’s Republic of China

    Jingxin Yang & Guang Cheng

  2. Robot Academy, Beijing Union University, Beijing, 100101, People’s Republic of China

    Jingxin Yang & Guang Cheng

  3. Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA

    Jingxin Yang, Jason L. Guo & Antonios G. Mikos

  4. Jinzhou Medical University, Jinzhou, 121000, People’s Republic of China

    Chunyan He

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  1. Jingxin Yang
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Correspondence to Jingxin Yang.

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Associate Editor Debra T. Auguste oversaw the review of this article.

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Yang, J., Guo, J.L., Mikos, A.G. et al. Material Processing and Design of Biodegradable Metal Matrix Composites for Biomedical Applications. Ann Biomed Eng 46, 1229–1240 (2018). https://doi.org/10.1007/s10439-018-2058-y

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  • DOI: https://doi.org/10.1007/s10439-018-2058-y

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