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Three-Dimensional Printing of Tissue/Organ Analogues Containing Living Cells

  • Additive Manufacturing of Biomaterials, Tissues, and Organs
  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

The technical advances of three-dimensional (3D) printing in the field of tissue engineering have enabled the creation of 3D living tissue/organ analogues. Diverse 3D tissue/organ printing techniques with computer-aided systems have been developed and used to dispose living cells together with biomaterials and supporting biochemicals as pre-designed 3D tissue/organ models. Furthermore, recent advances in bio-inks, which are printable hydrogels with living cell encapsulation, have greatly enhanced the versatility of 3D tissue/organ printing. Here, we introduce 3D tissue/organ printing techniques and biomaterials that have been developed and widely used thus far. We also review a variety of applications in an attempt to repair or replace the damaged or defective tissue/organ, and develop the in vitro tissue/organ models. The potential challenges are finally discussed from the technical perspective of 3D tissue/organ printing.

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Acknowledgments

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2010-0018294).

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The authors have no financial conflicts of interest.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 790-784, Korea

    Jeong Hun Park, Jinah Jang, Jung-Seob Lee & Dong-Woo Cho

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  1. Jeong Hun Park
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  2. Jinah Jang
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  3. Jung-Seob Lee
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  4. Dong-Woo Cho
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Correspondence to Dong-Woo Cho.

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Associate Editor Amir Abbas Zadpoor oversaw the review of this article.

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Park, J.H., Jang, J., Lee, JS. et al. Three-Dimensional Printing of Tissue/Organ Analogues Containing Living Cells. Ann Biomed Eng 45, 180–194 (2017). https://doi.org/10.1007/s10439-016-1611-9

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  • DOI: https://doi.org/10.1007/s10439-016-1611-9

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