Abstract
We employ a mechanical model of sarcomere to quantitatively investigate how adenosine triphosphate (ATP) concentration affects motor force regulation during skeletal muscle contraction. Our simulation indicates that there can be negative cross-bridges resisting contraction within the sarcomere and higher ATP concentration would decrease the resistance force from negative cross-bridges by promoting their timely detachment. It is revealed that the motor force is well regulated only when ATP concentration is above a certain level. These predictions may provide insights into the role of ATP in regulating coordination among multiple motors.
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The project was supported by the National Natural Science Foundation of China (Grants 11372279, 11572285).
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Wei, J., Dong, C. & Chen, B. Effects of adenosine triphosphate concentration on motor force regulation during skeletal muscle contraction. Acta Mech. Sin. 33, 243–249 (2017). https://doi.org/10.1007/s10409-017-0637-z
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DOI: https://doi.org/10.1007/s10409-017-0637-z