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Clinical features of superior segmental optic hypoplasia: hospital-based study

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine the clinical features of patients diagnosed with superior segmental optic hypoplasia (SSOH) and to quantitatively compare retinal nerve fiber layer (RNFL) thickness in SSOH eyes, to that in normal subjects.

Study design

Retrospective comparative case series.

Methods

We examined the medical charts of 106 eyes of 59 patients with SSOH and 35 eyes of 35 normal subjects as controls. Forty-four of 59 patients had been examined by spectral-domain optical coherence tomography (SD-OCT). Eyes with SSOH were classified into a definite and a suspect type determined by standard automated perimetry. The definite type had inferior visual field (VF) defects, while the suspect type did not have inferior VF defects. The findings of the SD-OCT images of 35 eyes with SSOH were compared to those of the 35 normal eyes.

Results

Of the 106 eyes with SSOH, 56 (52.8%) were classified as the definite type and 50 (47.2%) as the suspect type. OCT showed that the average of the total RNFL thickness was significantly thinner in the SSOH group than in the normal group (P < 0.001; Mann-Whitney U test). Sectorial analysis demonstrated that the RNFL was thinner than controls in all quadrants (all P < 0.001; Mann-Whitney U test). The comparison of the hourly sectors showed that the RNFL was thinner at 10, 11, 12, 1, 2, 3, 5, and 6 o’clock sectors in the SSOH group than controls.

Conclusions

Approximately one-half of eyes with SSOH had a detectable VF defect. OCT showed that eyes with SSOH have a thinner RNFL than controls except in 4 o`clock and from 7 o’clock to 9 o’clock.

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Authors and Affiliations

  1. Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan

    Ayaka Yagasaki, Akira Sawada, Yusuke Manabe & Tetsuya Yamamoto

Authors
  1. Ayaka Yagasaki
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  2. Akira Sawada
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  3. Yusuke Manabe
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  4. Tetsuya Yamamoto
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Corresponding author

Correspondence to Ayaka Yagasaki.

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Conflicts of interest

A. Yagasaki, None; A. Sawada, None; Y. Manabe, None; T. Yamamoto, None. The authors have no proprietary or financial interest in any products used in this study.

Additional information

Corresponding author: Ayaka Yagasaki

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Yagasaki, A., Sawada, A., Manabe, Y. et al. Clinical features of superior segmental optic hypoplasia: hospital-based study. Jpn J Ophthalmol 63, 34–39 (2019). https://doi.org/10.1007/s10384-018-0634-1

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  • DOI: https://doi.org/10.1007/s10384-018-0634-1

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