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The role of osteoprotegerin (OPG) receptor activator for nuclear factor kappaB ligand (RANKL) in cardiovascular pathology – a review

Osteoprotegerin (OPG) und Receptor Activator for Nuclear Factor kappaB Ligand (RANKL) als Risikofaktoren für Entstehung und Schweregrad einer Koronaren Herzerkrankung – ein Review

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Zusammenfassung

Osteoprotegerin (OPG), Receptor activator of nuclear factor kappaB (RANK) und dessen Ligand (RANKL) werden nicht nur als Schlüsselregulatoren des Knochenstoffwechsels beschrieben, sondern auch als wichtige Regulatoren immunologischer Funktionen erkannt. Eine koronare Herzerkrankung (KHK) entwickelt sich über Jahre und ist sehr oft die Folge entzündlicher Prozesse, die eine Schädigung des Endothels verursachen. Die rezente Literatur beschreibt OPG bei Patienten mit einer KHK als wichtigen Prädiktor von Mortalität und Morbidität.

Summary

Initially described as key regulators in metabolic bone disease osteoprotegerin (OPG), receptor activator of nuclear factor kappa B (RANK) and RANK ligand (RANKL) have also been discriminated as regulators in immunologic function. Cardiovascular diseases (CVD) develop over many years in life and are often triggered by inflammatory processes within the vessel wall that lead to vascular remodeling. Recently some study groups have described OPG as a prognostic parameter for mortality and morbidity in cardiovascular patients.

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Authors and Affiliations

  1. Division of Cardiac Surgery, Department of Surgery, Medical University of Graz, Graz, Austria

    Daniela-Eugenia Malliga

  2. Division of Transplantation, Department of Surgery, Medical University of Graz, Graz, Austria

    Doris Wagner

  3. Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Astrid Fahrleitner-Pammer

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  1. Daniela-Eugenia Malliga
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  2. Doris Wagner
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  3. Astrid Fahrleitner-Pammer
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Correspondence to Astrid Fahrleitner-Pammer.

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Malliga, DE., Wagner, D. & Fahrleitner-Pammer, A. The role of osteoprotegerin (OPG) receptor activator for nuclear factor kappaB ligand (RANKL) in cardiovascular pathology – a review. Wien Med Wochenschr 161, 565–570 (2011). https://doi.org/10.1007/s10354-011-0022-7

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