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Quality of life in type 2 diabetics with gastroesophageal reflux disease: a case control study

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Summary

Background

To compare health- and disease-related quality of life (QoL) in patients with gastroesophageal reflux disease (GERD), with and without type 2 diabetes mellitus (T2DM).

Methods

In a retro-pro study of 29 non-diabetic and 30 diabetic GERD-patients who underwent complete esophageal testing because of GERD symptoms, three different QoL questionnaires [short-form 36 (SF-36) questionnaire, Gastrointestinal Quality of Life Index (GIQLI), GERD-health related QoL Index (GERD-HRQL)] and a standardized symptom questionnaire were analyzed.

Results

T2DM patients revealed higher body-mass-index levels (31.8 ± 6.3 vs. 28.2 ± 4.4 kg/m2, p = 0.004), whereas hiatal hernias were found less frequently in non-diabetics (82.8 vs. 32.1 %, p < 0.001). Lower esophageal sphincter pressures (LES) were higher in T2DM GERD-patients (11.1 ± 6.1 vs. 5.3 ± 4.0 mmHg; p < 0.001). In the SF-36 domains, “vitality” and “physical functioning,” T2DM patients revealed lower QoL (48.8 ± 20.3 vs. 60.0 ± 16.7, p = 0.023; and 64.7 ± 25.4 vs. 78.8 ± 19.8, p = 0.027; respectively). The GERD-HRQL (16.8 ± 13.1 vs. 18.8 ± 10.7, p > 0.05) and GIQLI (88.5 ± 25.1 vs. 94.0 ± 18.2, p  > 0.05) did not differ significantly.

Conclusions

T2DM had a major impact on health-related QoL in patients with proven GERD, with impairment of the SF-36 domains, “physical functioning” and “vitality”. GERD-specific QoL, however, was similar in diabetic and non-diabetic patients.

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Conflict of interest

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria

    R. Promberger, A. Spitzer, J. Lenglinger & W. Eilenberg

  2. Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria

    J. Ott

  3. Karl Landsteiner Institute for Clinical Surgery, General Hospital of Krems, Krems, Austria

    M. Gadenstätter

  4. Division of Vascular Surgery, Department of Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria

    C. Neumayer

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  1. R. Promberger
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Promberger, R., Spitzer, A., Ott, J. et al. Quality of life in type 2 diabetics with gastroesophageal reflux disease: a case control study. Eur Surg 45, 194–199 (2013). https://doi.org/10.1007/s10353-013-0219-7

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