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Pseudoartrosi e perdite di sostanza juxta-articolari

Juxta-articular non unions and bone defects

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Riassunto

Le pseudoartrosi (PSA) e le perdite di sostanza ossea juxta-articolari sono una rara complicanza in ortopedia e traumatologia, ma rappresentano situazioni assai impegnative dal punto di vista clinico e della scelta del trattamento.

Alcuni problemi coesistenti, come l’osteoporosi, la deformità, l’atrofia dei tessuti molli, l’eventuale presenza di infezione e la possibile compromissione articolare, ne complicano ancor più l’inquadramento e la scelta terapeutica. A tal fine abbiamo sviluppato un nuovo sistema classificativo: il Non Union Scoring System (NUSS) che consente di identificare forme di PSA prognosticamente omogenee, indipendentemente dal solo sospetto radiografico, e quindi di strutturare una piu? completa ricerca clinica per ricavarne un algoritmo di cura.

La scelta del trattamento di queste delicate situazioni deve prevedere quindi un approccio globale al paziente che permetta di pianificare una strategia di trattamento che consenta di ottenere una valida stabilità meccanica, di correggere eventuali deformità e di fornire un adeguato stimolo biologico, quando richiesto. In tale panorama, quale ruolo quindi possiamo attribuire alla fissazione esterna?

Abstract

Juxta-articular non unions and bone defects are a rare complication in orthopedics and traumatology, but they represent very difficult situations in terms of clinical outcome and treatment options.

Some coexisting problems, such as osteoporosis, deformity, bone loss, soft tissue atrophy, infection and the possible association of articular degeneration, usually make the grading and the treatment choice very difficult. For this purpose we have developed a new classification system: the Non Union Scoring System (NUSS) which allows to identify prognostically homogeneous forms of non unions, regardless of the radiographic aspect only, and then to structure a more complete clinical grading in order to obtain an algorithm of care.

The choice of treatment of these delicate situations should utilize a global approach to the patient so to allow the clinician to plan a treatment strategy. A good mechanical stability must be reached, the deformity has to be corrected and an appropriate biological stimulus must be provided when required. In this scenario, which role can we attribute to external fixation?

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Bibliografia

  1. Carpenter CA, Jupiter JB (1996) Blade plate reconstruction of metaphyseal nonunion of the tibia. Clin Orthop Relat Res 332:23–28

    Article  PubMed  Google Scholar 

  2. Chapman MW, Finkemeier CG (1999) Treatment of supracondylar nonunions of the femur with plate fixation and bone graft. J Bone Joint Surg 81:1217–1228

    PubMed  CAS  Google Scholar 

  3. Johnson EE, Urist MR, Finerman GA (1990) Distal metaphyseal tibial nonunion: deformity and bone loss treated by open reduction, internal fixation, and human bone morphogenetic protein (hBMP). Clin Orthop Relat Res 250:234–240

    PubMed  Google Scholar 

  4. King GJ, Schatzker J (1991) Nonunion of a complex tibial plateau fracture. J Orthop Trauma 5:209–212

    Article  PubMed  CAS  Google Scholar 

  5. Lonner JH, Siliski JM, Jupiter JB, Lhowe DW (1999) Posttraumatic nonunion of the proximal tibial metaphysis. Am J Orthop 28:523–528

    PubMed  CAS  Google Scholar 

  6. Mandt PR, Gershuni DH (1987) Treatment of nonunion of fractures in the epiphyseal-metaphyseal region of long bones. J Orthop Trauma 1:141–151

    Article  PubMed  CAS  Google Scholar 

  7. Matelic TM, Monroe MT, Mast JW (1996) The use of endosteal substitution in the treatment of recalcitrant nonunions of the femur: report of seven cases. J Orthop Trauma 10:1–6

    Article  PubMed  CAS  Google Scholar 

  8. Cole PA (2003) Endosteal allograft plating for the treatment of recalcitrant nonunions. Tech Orthop 18:344–355

    Article  Google Scholar 

  9. Koval KJ, Seligson D, Rosen H, Fee K (1995) Distal femoral nonunion: treatment with a retrograde inserted locked intramedullary nail. J Orthop Trauma 9:285–291

    Article  PubMed  CAS  Google Scholar 

  10. McLaren AC, Blokker CP (1991) Locked intramedullary fixation for metaphyseal malunion and nonunion. Clin Orthop Relat Res 265:253–260

    PubMed  Google Scholar 

  11. Bishop AT, Wood MB, Sheetz KK (1995) Arthrodesis of the ankle with a free vascularized autogenous bone graft: reconstruction of segmental loss of bone secondary to osteomyelitis, tumor, or trauma. J Bone Joint Surg 77:1867–1875

    PubMed  CAS  Google Scholar 

  12. Yajima H, Tamai S, Mizumoto S, Inada Y (1993) Vascularized fibular grafts in the treatment of osteomyelitis and infected nonunion. Clin Orthop Relat Res 293:256–264

    PubMed  Google Scholar 

  13. Marsh JL, Rattay RE, Dulaney T (1997) Results of ankle arthrodesis for treatment of supramalleolar nonunion and ankle arthrosis. Foot Ankle Int 18:138–143

    PubMed  CAS  Google Scholar 

  14. Gruen GS, Mears DC (1991) Arthrodesis of the ankle and subtalar joints. Clin Orthop Relat Res 268:15–20

    PubMed  Google Scholar 

  15. Lonner JH, Koval KJ, Golyakhovsky V, Frankel VH (1995) Posttraumatic nonunion of the distal tibial metaphysis: treatment using the Ilizarov circular external fixator. Am J Orthop May (Suppl):16–21

  16. Paley D, Catagni MA, Argnani F et al (1989) Ilizarov treatment of tibial nonunions with bone loss. Clin Orthop Relat Res 241:146–165

    PubMed  Google Scholar 

  17. Martin JA, Ellerbroek SM, Buckwalter JA (1997) Age-related decline in chondrocyte response insulin like growth factor-I: the role of growth factor binding proteins. J Orthop Res 15:491–498

    Article  PubMed  CAS  Google Scholar 

  18. Lill CA, Hesseln J, Schelegen U et al (2003) Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis. J Orthop Res 21:836–842

    Article  PubMed  CAS  Google Scholar 

  19. Healy WL, White GM, Mick CA et al (1987) Nonunion of humeral shaft. Clin Orthop Relat Res 219:206–213

    PubMed  Google Scholar 

  20. Einhorn TA, Bonnorens F, Burstein AH (1986) The contributions of dietary protein and mineral in the healing of experimental fracture. A biomechanical study. J Bone Joint Surg 68:1389–1395

    PubMed  CAS  Google Scholar 

  21. Adam CI, Kenting JF, Court-Brown CM (2001) Cigarette smoking and open tibial fractures. Injury 32:61–65

    Article  Google Scholar 

  22. Ziran B, Cheung S, Smith W, Westerheide K (1995) Comparative efficacy of 2 different demineralized bone matrix allografts in treating long-bone nonunions in heavy tobacco smokers. Am J Orthop 34:329–332

    Google Scholar 

  23. Calori GM, Albisetti W, Agus A et al (2007) Risk factors contributing to fracture non-unions Injury 38:S11–S18

    Article  PubMed  Google Scholar 

  24. Calori GM, Phillips M, Jeetle S et al (2008) Classification of nonunion: need for a new scoring system? Injury 39:S59–S63

    Article  PubMed  Google Scholar 

  25. Kanakaris NK, Calori GM, Verdonk R et al (2008) Application of BMP-7 to tibial non-unions: a 3-year multicenter experience. Injury 39:S83–S90

    Article  PubMed  Google Scholar 

  26. Calori GM, Tagliabue L, Gala L et al (2008) Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomized clinical study on 120 patients. Injury 39:1391–1402

    Article  PubMed  CAS  Google Scholar 

  27. Kanakaris NK, Lasanianos N, Calori GM et al (2009) Application of bone morphogenetic proteins to femoral non-unions: a 4-year multicentre experience. Injury 40:S54–S61

    Article  PubMed  Google Scholar 

  28. Calori GM, Mazza E, Colombo M et al (2011) Treatment of long bone non unions with polytherapy: indications and clinical results. Injury 42:587–590

    Article  PubMed  CAS  Google Scholar 

  29. Calori GM, Colombo M, Ripamonti C et al (2011) Polytherapy in bone regeneration: clinical applications and preliminary considerations. Int J Immunopathol Pharmacol 24:85–90

    PubMed  CAS  Google Scholar 

  30. Masquelet AC, Fitoussi F, Begue T, Muller GP (2000) Reconstruction of long bones induced membrane and spongy autograft. Ann Chir Plast Esthet 45:346–353

    PubMed  CAS  Google Scholar 

  31. Pelissier P, Masquelet AC, Bareille R et al (2004) Induced membranes secrete growth factors including vascular and osteoinductive factors, and could stimulate bone regeneration. J Orthop Res 22:73–79

    Article  PubMed  CAS  Google Scholar 

  32. Calori GM, Giannoudis PV (2011) Enhancement of fracture healing with the diamond concept: the role of the biological chamber. Injury 42:1191–1193

    Article  PubMed  Google Scholar 

  33. McCall TA, Brokaw DS, Jelen BA et al (2010) Treatment of large segmental bone defects with reamer-irrigator-aspirator bone graft: technique and case series. Orthop Clin North Am 41:63–73

    Article  PubMed  Google Scholar 

  34. Calori GM, Tagliabue L, Colombo M et al (2010) Pseudoartrosi e perdite di sostanza. GIOT 36:183–189

    Google Scholar 

  35. Keramaris NC, Calori GM, Nikolaou VS et al (2008) Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury 39:S45–S57

    Article  PubMed  Google Scholar 

  36. McKibbin B (1978) The biology of fracture healing in long bones. J Bone Joint Surg 60:150–162

    Google Scholar 

  37. Rhinelander FW (1974) Tibial blood supply in relation to fracture healing. Clin Orthop Relat Res 105:34–81

    Article  PubMed  Google Scholar 

  38. Kanakaris NK, Mallina R, Calori GM et al (2009) Use of bone morphogenetic proteins in arthrodesis: clinical results. Injury 40:S62–S66

    Article  PubMed  Google Scholar 

  39. Anderson SP, Matthews LS, Kaufer H (1990) Treatment of juxtaarticular nonunion fractures at the knee with long-stem total knee arthroplasty. Clin Orthop Relat Res 260:104–109

    PubMed  Google Scholar 

  40. Kress KJ, Scuderi GR, Windsor RE, Insall JN (1993) Treatment of nonunions about the knee utilizing custom total knee arthroplasty with press-fit intramedullary stems. J Arthroplasty 8: 49–55

    Article  PubMed  CAS  Google Scholar 

  41. Ring D, Jupiter JB, Gan BS et al (1999) Infected nonunion of the tibia. Clin Orthop Relat Res 369:302–311

    Article  PubMed  Google Scholar 

  42. Minematsu K, Tsuchiya H, Taki J, Tomita K (1998) Blood flow measurement during distraction osteogenesis. Clin Orthop Relat Res 347:229–235

    Article  PubMed  Google Scholar 

  43. Calori GM, Mazza E, Colombo M, Ripamonti C (2011) The use of bone-graft substitutes in large bone defects: any specific needs? Injury 42:S56–S63

    Article  PubMed  Google Scholar 

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Calori, G.M., Bucci, M., Fadigati, P. et al. Pseudoartrosi e perdite di sostanza juxta-articolari. Aggiornamenti 18, 71–76 (2012). https://doi.org/10.1007/s10351-012-0012-2

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  • DOI: https://doi.org/10.1007/s10351-012-0012-2

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