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Arterial input function in a dedicated slice for cerebral perfusion measurements in humans

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Abstract

Object

We aimed to modify our previously published method for arterial input function measurements for evaluation of cerebral perfusion (dynamic susceptibility contrast MRI) such that it can be applied in humans in a clinical setting.

Materials and methods

Similarly to our previous work, a conventional measurement sequence for dynamic susceptibility contrast MRI is extended with an additional measurement slice at the neck. Measurement parameters at this slice were optimized for the blood signal (short echo time, background suppression, magnitude and phase images). Phase-based evaluation of the signal in the carotid arteries is used to obtain quantitative arterial input functions.

Results

In all pilot measurements, quantitative arterial input functions were obtained. The resulting absolute perfusion parameters agree well with literature values (gray and white matter mean values of 46 and 24 mL/100 g/min, respectively, for cerebral blood flow and 3.0% and 1.6%, respectively, for cerebral blood volume).

Conclusions

The proposed method has the potential to quantify arterial input functions in the carotid arteries from a direct measurement without any additional normalization.

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Acknowledgements

We are grateful to Hansjörg Mast. The work was supported by the German Research Council (grants KI-1089/2-1 and MA 2343/4-1).

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Authors and Affiliations

  1. Department of Radiology, Medical Physics, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Breisacher Str. 60a, 79115, Freiburg, Germany

    Elias Kellner, Marco Reisert & Valerij Gennadevic Kiselev

  2. Department of Neuroradiology, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Breisacher Str. 60a, Freiburg, 79115, Germany

    Irina Mader & Horst Urbach

Authors
  1. Elias Kellner
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  2. Irina Mader
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  3. Marco Reisert
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  5. Valerij Gennadevic Kiselev
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Contributions

Author contributions

EK was responsible for protocol/project development, data collection or management, and data analysis. IM was responsible for protocol/project development and data collection or management. MR was responsible for data analysis. HU was responsible for data collection or management. VGK was responsible for protocol/project development and data analysis.

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Correspondence to Elias Kellner.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards..

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Kellner, E., Mader, I., Reisert, M. et al. Arterial input function in a dedicated slice for cerebral perfusion measurements in humans. Magn Reson Mater Phy 31, 439–448 (2018). https://doi.org/10.1007/s10334-017-0663-7

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  • DOI: https://doi.org/10.1007/s10334-017-0663-7

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