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Diffusional kurtosis imaging (DKI) incorporation into an intravoxel incoherent motion (IVIM) MR model to measure cerebral hypoperfusion induced by hyperventilation challenge in healthy subjects

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Abstract

Objectives

The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects.

Materials and methods

Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI–IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions.

Results

A significant reduction in the perfusion fraction (f) and in the product fD* of the perfusion fraction with the pseudodiffusion coefficient (D*) was found with the DKI–IVIM model, during the hyperventilation challenge. In the cerebellum GM, the percentage changes were f: −43.7 ± 40.1, p = 0.011 and fD*: −50.6 ± 32.1, p = 0.011; in thalamus GM, f: −47.7 ± 34.7, p = 0.012 and fD*: −47.2 ± 48.7, p = 0.040. In comparison, using the bi-exponential IVIM model, only a significant decrease in the parameter fD* was observed for the same regions of interest. In frontal-GM and posterior-GM, the reduction in f and fD* did not reach statistical significance, either with DKI–IVIM or the bi-exponential IVIM model.

Conclusion

When compared to the bi-exponential IVIM model, the DKI–IVIM model displays a higher sensitivity to detect changes in perfusion induced by the hyperventilation condition.

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Acknowledgements

This study was supported by the Conseil Scientifique et Méthodologique (CSM) of the University Hospital of Martinique (CHU).

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Authors and Affiliations

  1. INSERM, UMR 1099, 35000, Rennes, France

    Aude Pavilla, Giulio Gambarota & Hervé Saint-Jalmes

  2. Université de Rennes 1, LTSI, 35000, Rennes, France

    Aude Pavilla, Giulio Gambarota & Hervé Saint-Jalmes

  3. Department of Neuroradiology, Pierre-Zobda-Quitman Hospital, University Hospital of Martinique, Fort-de- France, Martinique, France

    Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi & Régis Duvauferrier

  4. CRLCC, Centre Eugène Marquis, 35000, Rennes, France

    Hervé Saint-Jalmes

Authors
  1. Aude Pavilla
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  2. Giulio Gambarota
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  3. Alessandro Arrigo
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  4. Mehdi Mejdoubi
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  5. Régis Duvauferrier
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  6. Hervé Saint-Jalmes
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Contributions

Pavilla: protocol/data collection/data analysis; Gambarota: protocol/data analysis/project development; Arrigo: protocol/data collection management/project development; Mejdoubi: Protocol/project development; Duvauferrier: protocol/project development; Saint-Jalmes: protocol/data analysis/project development

Corresponding author

Correspondence to Aude Pavilla.

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The authors each declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were approved by the appropriate ethics committee and were therefore performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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Pavilla, A., Gambarota, G., Arrigo, A. et al. Diffusional kurtosis imaging (DKI) incorporation into an intravoxel incoherent motion (IVIM) MR model to measure cerebral hypoperfusion induced by hyperventilation challenge in healthy subjects. Magn Reson Mater Phy 30, 545–554 (2017). https://doi.org/10.1007/s10334-017-0629-9

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  • DOI: https://doi.org/10.1007/s10334-017-0629-9

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