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Single-breath-hold 3-D CINE imaging of the left ventricle using Cartesian sampling

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Abstract

Objectives

Our objectives were to evaluate a single-breath-hold approach for Cartesian 3-D CINE imaging of the left ventricle with a nearly isotropic resolution of \(1.9 \times 1.9 \times 2.5\,{\text {mm}^3}\) and a breath-hold duration of \(\sim \)19 s against a standard stack of 2-D CINE slices acquired in multiple breath-holds. Validation is performed with data sets from ten healthy volunteers.

Materials and methods

A Cartesian sampling pattern based on the spiral phyllotaxis and a compressed sensing reconstruction method are proposed to allow 3-D CINE imaging with high acceleration factors. The fully integrated reconstruction uses multiple graphics processing units to speed up the reconstruction. The 2-D CINE and 3-D CINE are compared based on ventricular function parameters, contrast-to-noise ratio and edge sharpness measurements.

Results

Visual comparisons of corresponding short-axis slices of 2-D and 3-D CINE show an excellent match, while 3-D CINE also allows reformatting to other orientations. Ventricular function parameters do not significantly differ from values based on 2-D CINE imaging. Reconstruction times are below 4 min.

Conclusion

We demonstrate single-breath-hold 3-D CINE imaging in volunteers and three example patient cases, which features fast reconstruction and allows reformatting to arbitrary orientations.

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Acknowledgements

The authors gratefully acknowledge funding of the Erlangen Graduate School in Advanced Optical Technologies (SAOT) by the German Research Foundation (DFG) in the framework of the German excellence initiative.

Author contributions

JW: protocol and project development, data collection and analysis. MS: protocol development, data collection and analysis. FP: data collection and analysis. BL: data collection and analysis. FL: data collection and management. AM: project development. JH: project development. CF: protocol and project development, data collection and analysis

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Authors and Affiliations

  1. Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Martensstr. 3, 91058, Erlangen, Germany

    Jens Wetzl, Felix Lugauer, Andreas Maier & Joachim Hornegger

  2. Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Jens Wetzl, Andreas Maier & Joachim Hornegger

  3. Siemens Healthcare GmbH, Erlangen, Germany

    Michaela Schmidt & Christoph Forman

  4. Department of Cardiovascular Imaging, CHU Lille and Univ. Lille, 59000, Lille, France

    François Pontana & Benjamin Longère

Authors
  1. Jens Wetzl
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  3. François Pontana
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Correspondence to Jens Wetzl.

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Conflict of interest

Jens Wetzl and Felix Lugauer receive project funding from Siemens Healthcare GmbH. Michaela Schmidt and Christoph Forman are employees of Siemens Healthcare GmbH. François Pontana receives research support from Siemens Healthcare GmbH.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Wetzl, J., Schmidt, M., Pontana, F. et al. Single-breath-hold 3-D CINE imaging of the left ventricle using Cartesian sampling. Magn Reson Mater Phy 31, 19–31 (2018). https://doi.org/10.1007/s10334-017-0624-1

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  • DOI: https://doi.org/10.1007/s10334-017-0624-1

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