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The aging effect on prostate metabolite concentrations measured by 1H MR spectroscopy

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Abstract

Objective

The effects of aging, magnetic field and the voxel localization on measured concentrations of citrate (Cit), creatine (Cr), cholines (Cho) and polyamines (PA) in a healthy prostate were evaluated.

Materials and methods

36 examinations at both 1.5T and 3T imagers of 52 healthy subjects aged 19–71 years were performed with PRESS 3D-CSI sequences (TE = 120 and 145 ms). Concentrations in laboratory units and their ratios to citrate were calculated using the LCModel technique. Absolute concentrations were also obtained after the application of correction coefficients. Statistical analysis was performed using a robust linear mixed effects model.

Results

Significant effects of aging, the magnetic field strength and the voxel position in central (CZ) or peripheral (PZ) zones on all measured metabolites were found. The concentrations (mmol/kg wet tissue) including prediction intervals in a range of 20–70 years were found: Cit: 7.9–17.2; Cho: 1.4–1.7; Cr: 2.8-2.5; PA (as spermine): 0.6–2.1 at 3T in CZ. In PZ, the concentrations were higher by about 10 % as compared to CZ.

Conclusion

Increasing citrate and spermine concentrations with age are significant and correlate well with a recently described increase of zinc in the prostate. These findings should be considered in decision-making if the values obtained from a subject are in the range of control values.

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Acknowledgments

The study was supported by the Ministry of Health of the Czech Republic: Internal Grant Agency No. NT13017 and the grant project for development of research organization 00023001IKEM, Institutional support. We give thanks to Siemens for providing us with Work-In-Progress sequence GRESHIM.

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Authors and Affiliations

  1. MR-Unit, Department of Diagnostic and Interventional Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021, Prague 4, Czech Republic

    Monika Dezortova, Filip Jiru, Antonin Skoch, Vaclav Capek, Zuzana Ryznarova & Milan Hajek

  2. Department of Urology, Thomayer Hospital, Videnska 800, 14000, Prague 4, Czech Republic

    Viktor Vik

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  1. Monika Dezortova
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  2. Filip Jiru
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  3. Antonin Skoch
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  6. Viktor Vik
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  7. Milan Hajek
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Correspondence to Monika Dezortova.

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All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Dezortova, M., Jiru, F., Skoch, A. et al. The aging effect on prostate metabolite concentrations measured by 1H MR spectroscopy. Magn Reson Mater Phy 30, 65–74 (2017). https://doi.org/10.1007/s10334-016-0584-x

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  • DOI: https://doi.org/10.1007/s10334-016-0584-x

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