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Multi-Slice DCE-MRI Data Using P760 Distinguishes Between Metastatic and Non-Metastatic Rodent Prostate Tumors

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Abstract

An intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1 prostate tumors originally derived from the Dunning prostate cancer model were implanted on the hind leg of Copenhagen rats. Multi-sliced DCE-MRI data were acquired on a SIGNA 1.5 T scanner and analyzed using a recently developed empirical mathematical model. The P760 multi-slice DCE-MRI data in combination with the empirical mathematical model successfully distinguished between metastatic and non-metastatic rodent prostate tumors. Specifically, fitting the data with the empirical model showed that metastatic tumors had significantly faster contrast media uptake (p<0.001) and slower washout rates (p<0.01) than non-metastatic tumors

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Authors and Affiliations

  1. Department of Radiology, University of Chicago, Chicago, IL, 60637, USA

    Xiaobing Fan, Milica Medved, Sean Foxley, Jonathan N. River, Marta Zamora & Gregory S. Karczmar

  2. Guerbet Laboratories, 95943, Roissy Charles De Gaulle, Cedex, France

    Claire Corot, Philippe Robert & Philippe Bourrinet

Authors
  1. Xiaobing Fan
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  2. Milica Medved
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  3. Sean Foxley
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  4. Jonathan N. River
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  5. Marta Zamora
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  6. Gregory S. Karczmar
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  7. Claire Corot
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  8. Philippe Robert
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  9. Philippe Bourrinet
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Correspondence to Xiaobing Fan.

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Fan, X., Medved, M., Foxley, S. et al. Multi-Slice DCE-MRI Data Using P760 Distinguishes Between Metastatic and Non-Metastatic Rodent Prostate Tumors. Magn Reson Mater Phy 19, 15–21 (2006). https://doi.org/10.1007/s10334-005-0022-y

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  • DOI: https://doi.org/10.1007/s10334-005-0022-y

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