Skip to main content
SpringerLink
Log in

„The new kids on the block“

Elagolix und Relugolix verändern die Behandlung von Endometriose und Uterus myomatosus

“The new kids on the block”

Elagolix and Relugolix are changing the treatment of endometriosis and uterine fibroids

  • Medizin aktuell
  • Published:
Gynäkologische Endokrinologie Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Diedrich K, Diedrich C, Santos E, Zoll C, al-Hasani S, Reissmann T, Krebs D, Klingmüller D (1994) Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist cetrorelix during ovarian stimulation. Hum Reprod 9(5):788–791

    Article  CAS  Google Scholar 

  2. Felberbaum RE, Ludwig M, Diedrich K (2000) Clinical application of GnRH-antagonists. Mol Cell Endocrinol 166(1):9–14

    Article  CAS  Google Scholar 

  3. Felberbaum RE, Reissmann T, Küpker W et al (1995) Preserved pituitary response under ovarian stimulation with HMG and GnRH antagonists (cetrorelix) in women with tubal infertility. Eur J Obstet Gynecol Reprod Biol 61:151–155

    Article  CAS  Google Scholar 

  4. Griesinger G, von Otte S, Schroer A, Ludwig AK, Diedrich K, Al-Hasani S, Schultze-Mosgau A (2007) Elective cryopreservation of all pronuclear oocytes after GnRH agonist triggering of final oocyte maturation in patients at risk of developing OHSS: a prospective, observational proof-of-concept study. Hum Reprod 22(5):1348–1352

    Article  CAS  Google Scholar 

  5. Barbieri RL (1998) Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment. J Reprod Med 43(3):287–292

    CAS  PubMed  Google Scholar 

  6. Kettel LM, Murphy AA, Morales AJ, Rivier J, Vale W, Yen SS (1993) Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist. Fertil Steril 60(4):642–646

    Article  CAS  Google Scholar 

  7. Felberbaum RE, Germer U, Ludwig M, Riethmüller-Winzen H, Heise S, Buttge I, Bauer O, Reissmann T, Engel J, Diedrich K (1998) Treatment of uterine fibroids with a slow-release formulation of the gonadotrophin releasing hormone antagonist cetrorelix. Hum Reprod 13(6):1660–1668

    Article  CAS  Google Scholar 

  8. Felberbaum RE, Küpker W, Krapp M, Gehl B, Ludwig M, Diedrich K (2001) Preoperative reduction of uterine fibroids in only 16 days by administration of a gonadotrophin-releasing hormone antagonist (cetrotide). Reprod Biomed Online 3(1):14–18. https://doi.org/10.1016/s1472-6483(10)61957-8

    Article  CAS  PubMed  Google Scholar 

  9. Flierman PA, Oberyé JJ, van der Hulst VP, de Blok S (2005) Rapid reduction of leiomyoma volume during treatment with the GnRH antagonist ganirelix. BJOG 112(5):638–642

    Article  CAS  Google Scholar 

  10. Küpker W, Felberbaum RE, Krapp M, Schill T, Malik E, Diedrich K (2002) Use of GnRH antagonists in the treatment of endometriosis. Reprod Biomed Online 5(1):12–16

    Article  Google Scholar 

  11. Taylor HS, Giudice LC, Lessey BA, Abrao MS, Kotarski J, Archer DF, Diamond MP, Surrey E, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Rowan JP, Duan WR, Ng J, Schwefel B, Thomas JW, Jain RI, Chwalisz K (2017) Treatment of endometriosis-associated pain with elagolix, an oral GnRH antagonist. N Engl J Med 377(1):28–40

    Article  CAS  Google Scholar 

  12. Surrey E, Taylor HS, Giudice L, Lessey BA, Abrao MS, Archer DF, Diamond MP, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Singh SS, Rechberger T, Agarwal SK, Duan WR, Schwefel B, Thomas JW, Peloso PM, Ng J, Soliman AM, Chwalisz K (2018) Long-term outcomes of elagolix in women with endometriosis: results from two extension studies. Obstet Gynecol 132(1):147–160

    Article  CAS  Google Scholar 

  13. Schlaff WD, Ackerman RT, Al-Hendy A, Archer DF, Barnhart KT, Bradley LD, Carr BR, Feinberg EC, Hurtado SM, Kim J, Liu R, Mabey RG Jr, Owens CD, Poindexter A, Puscheck EE, Rodriguez-Ginorio H, Simon JA, Soliman AM, Stewart EA, Watts NB, Muneyyirci-Delale O (2020) Elagolix for heavy menstrual bleeding in women with uterine fibroids. N Engl J Med 382(4):328–340

    Article  CAS  Google Scholar 

  14. Food and Drug Administration (2020) ORIAHNN (elagolix, estradiol, and norethindrone acetate capsules; elagolix capsules),co-packaged for oraluseinitial U.S. Approval

    Google Scholar 

  15. Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, Critchley HOD, Li Y, McKain L, Arjona Ferreira JC, Langenberg AGM, Wagman RB, Stewart EA (2021) Treatment of uterine fibroid symptoms with relugolix combination therapy. N Engl J Med 384(7):630–642

    Article  CAS  Google Scholar 

  16. EMA/318437/2021 EMEA/H/C/005267

  17. Osuga Y, Seki Y, Tanimoto M, Kusumoto T, Kudou K, Terakawa N (2021) Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose-response manner: a randomized, double-blind, placebo-controlled study. Fertil Steril 115(2):397–405

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. KinderWunschKempten, Zentrum für gynäkologische Endokrinologie und Reproduktionsmedizin, Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Kempten, Akademisches Lehrkrankenhaus der Universität Ulm, Klinikverbund Allgäu, Kempten, Deutschland, 87439, Robert-Weixler Strasse 50

    Ricardo Felberbaum

  2. Zentrum für Reproduktionsmedizin und gynäkologische Endokrinologie, IVF Baden-Baden, Baden-Baden, Deutschland

    Wolfgang Küpker

  3. Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland

    Klaus Diedrich

Authors
  1. Ricardo Felberbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wolfgang Küpker
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Klaus Diedrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ricardo Felberbaum.

Ethics declarations

Interessenkonflikt

R. Felberbaum, W. Küpker und K. Diedrich geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

Redaktion

Ricardo Felberbaum, Kempten

figure qr

QR-Code scannen & Beitrag online lesen

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Felberbaum, R., Küpker, W. & Diedrich, K. „The new kids on the block“. Gynäkologische Endokrinologie 20, 154–156 (2022). https://doi.org/10.1007/s10304-022-00448-4

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10304-022-00448-4

Search

Navigation