Abstract
Patients with hematologic cancers often develop acute and chronic oral complications from their disease and its treatment. These problems could change patients’ oral health-related quality of life (OHRQoL) negatively. Quality of life (QoL) has become an increasingly important outcome measure in oncology. This systematic literature review evaluates the impact of hematological malignancies and their treatment on OHRQoL as assessed by the Oral Health Impact Profile (OHIP-14) questionnaire. Medline through Pubmed and Web of Science were searched through April 2017. Two randomized controlled trials, one cohort study, one cross-sectional study, and one case–control study were included. Heterogeneity across the included studies did not allow for meta-analysis. OHIP-14 domains that were frequently given the highest scores were functional limitation (67%), physical pain (50%), physical disability (50%), and psychological discomfort (33%). The domains that were frequently given the lowest scores were social handicap (100%), social disability (100%), and psychological disability (67%). Insufficient evidence is available to draw any robust conclusions regarding OHRQoL assessed by the OHIP-14 in individuals with hematological malignancies. However, functional limitations because of problems with oral mucosal tissues, the dentition, or dentures, seem to have a larger negative impact on the OHRQoL than social aspects associated with oral health problems. Well-designed larger studies are required to determine effects of hematological malignancies as well as acute and long-term effects of their treatment on patients’ OHRQoL
Similar content being viewed by others
References
Kim HS, Lim CS. Oral signs of acute leukemia for early detection. J Periodontal Implant Sci. 2014;44:293–9.
de Almeida TMX, Cavalcanti EFF, da Silva Freitas A, Pessoa de Magalhães RJ, Maiolino A, Torres SR. Can dentists detect multiple myeloma through oral manifestations? Hematol Transfus Cell Ther. 2018;40:43–9.
Bellm LA, Epstein JB, Rose-Ped A, Martin P, Fuchs HJ. Patient reports of complications of bone marrow transplantation. Support Care Cancer. 2000;8:33–9.
Rogers SN. Quality of life perspectives in patients with oral cancer. Oral Oncol. 2010;46:445–7.
Brand HS, Bots CP, Raber-Durlacher JE. Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation. Br Dent J. 2009;207(E1):E7.
Elad S, Raber-Durlacher JE, Brennan MT, Saunders DP, Mank AP, Zadik Y, et al. Basic oral care for hematology–oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Support Care Cancer. 2015;23:223–36.
Treister N, Duncan C, Cutler C, Lehmann L. How we treat oral chronic graft-versus-host disease. Blood. 2012;120:3407–18.
Bottomley A. The cancer patient and quality of life. Oncologist. 2002;7:120–5.
WHOQOL. The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med. 1995;41:1403–9.
Slade GD, Spencer AJ. Development and evaluation of the Oral Health Impact Profile. Community Dent Health. 1994;11:3–11.
Roumani TI, Oulis CJ, Papagiannopoulou V, Yfantopoulos J. Validation of a Greek version of the oral health impact profile (OHIP-14) in adolescents. Eur Arch Paediatr Dent. 2010;11(suppl 5):247–52.
Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
Bardellini F, Amadori F, Majorana A. Oral hygiene grade and quality of life in children with chemotherapy-related oral mucositis: a randomized study on the impact of a fluoride toothpaste with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol. Int J Dent Hyg. 2016;14:314–9.
Silva LC, Sacono NT, Freire MC, Costa LR, Batista AC, Silva GBL. The impact of low-level laser therapy on oral mucositis and quality of life in patients undergoing hematopoietic stem cell transplantation using the oral health impact profile and the functional assessment of cancer therapy-bone marrow transplantation questionnaires. Photomed Laser Surg. 2015;33:357–63.
Bezinelli LM, Eduardo FP, Neves VD, Correa L, Lopes RM, Michel-Crostato E, et al. Quality of life related to oral mucositis of patients undergoing haematopoietic stem cell transplantation and receiving specialised oral care with low-level laser therapy: a prospective observational study. Eur J Cancer Care. 2016;25:6668–74.
Grando LJ, Mello ALSF, Salvato L, Brancher AP, Del Moral JAG, Steffenello-Durigon G. Impact of leukemia and lymphoma chemotherapy on oral cavity and quality of life. Spec Care Dentist. 2015;35:236–42.
Tinoco-Araujo JE, Orti-Raduan ESL, Santos D, Colturato VAR, Souza MP, Mauad MA, et al. Oral health-related quality of life before hematopoietic stem cell transplantation. Clin Oral Investig. 2015;19:2345–9.
Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L, et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin. 2012;62:400–22.
Naidu MU, Ramana GV, Rani PU, Mohan IK, Suman A, Roy P. Chemotherapy-induced and/or radiation therapy-induced oral mucositis—complicating the treatment of cancer. Neoplasia. 2004;6:423–31.
Weckx LLM, Hidal LBTH, Marcucci G. Oral manifestations of leukemia. Ear Nose Throat J. 1990;49:341–6.
Sonis S, Kunz A. Impact of improved dental services on the frequency of oral complications of cancer therapy for patients with non-head-and-neck malignancies. Oral Surg Oral Med Oral Pathol Oral Radiol. 1988;65:19–22.
Savage DG, Szydlo RM, Goldman JM. Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period. Br J Haematol. 1997;96:111–6.
Woo SB, Lee SJ, Schubert MM. Graft-vs.-host disease. Crit Rev Oral Biol Med. 1997;8:201–16.
Schubert MM, Sullivan KM, Morton TH, Izutsu KT, Peterson DE, Flournoy N, et al. Oral manifestations of chronic graft-v-host disease. Arch Intern Med. 1984;144:1591–5.
Raber-Durlacher JE, Epstein JB, Bresters D, Stern-Zivan L. Oral complications in children with cancer. Eur J Paediatr Dent. 2005;5:3–13.
Shi HB, Masuda M, Umezaki T, Kuratomi Y, Kumamoto Y, Yamamoto T, et al. Irradiation impairment of umami taste in patients with head and neck cancer. Auris Nasus Larynx. 2004;31:401–6.
Watters AL, Epstein JB, Agulnik M. Oral complications of targeted cancer therapies: a narrative literature review. Oral Oncol. 2011;47:441–8.
Comeau TB, Epstein JB, Migas C. Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer. 2001;9:575–80.
Raber-Durlacher JE, Brennan MT, Verdonck-de Leeuw IM, Gibson RJ, Eilers JG, Waltimo T, et al. Swallowing dysfunction in cancer patients. Support Care Cancer. 2011;20:433–43.
Van der Meulen MJ, John MT, Naeije M, Lobbezoo F. The Dutch version of the Oral Health Impact Profile (OHIP-NL): translation, reliability and construct validity. BMC Oral Health. 2008;8:11.
Bjordal K, Graeff de A, Fayers PM, Hammerlid E, van Pottelsberghe C, Curran D, et al. A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients. EORTC Quality of Life Group. Eur J Cancer. 2000;36:1796–807.
Hjermstad MJ, Bergenmar M, Bjordal K, Fisher SE, Hofmeister D, Montel S, et al. International field testing of the psychometric properties of an EORTC quality of life module for oral health: the EORTC QLQ-OH15. EORTC Quality of Life Group. Support Care Cancer. 2016;2:3915–21.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Stolze, J., Vlaanderen, K.C.E., Raber-Durlacher, J.E. et al. The impact of hematological malignancies and their treatment on oral health-related quality of life as assessed by the OHIP-14: a systematic review. Odontology 108, 511–520 (2020). https://doi.org/10.1007/s10266-019-00479-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10266-019-00479-7