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Self-reported periodontitis and migraine: results from a multicenter, cross-sectional survey in Spain

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Abstract

The aim of this study was to evaluate self-reported periodontitis (PD) prevalence in migraineurs as well as to investigate the association between both diseases. A cross-sectional survey was carried out including patients diagnosed with migraine attending 12 Spanish Headache Units. We determined diagnosis of PD administering a validated self-reported questionnaire. Socio-demographic, clinical and medical information, comorbidities, daily habits, migraine characteristics and medication were collected using a questionnaire. Of the 651 consecutive migraineurs included in the study, 393 suffered from chronic migraine (CM). Self-reported PD was detected in 327 patients with migraine (50.2%). Migraineurs with self-reported PD were significantly older and had a previous history of fibromyalgia, stress, anxiety, depression, and allodynia (all P < 0.001). Additionally, this group of patients consumed more topiramate (P = 0.008) and simple analgesics (P < 0.001) than patients with migraine and without self-reported PD. Also, they were less active physically and belonged to a low education level (both P < 0.001). Prevalence of self-reported PD was significantly higher in chronic migraineurs compared to those diagnosed with episodic migraine (EM) (53.9% vs. 44.6%, P = 0.019). Logistic regression analyses showed that self-reported PD was associated with CM (OR 1.456; 95% CI 1.062–1.997, P = 0.020). However, after adjusting for significant confounders, the association was attenuated (OR 1.100; 95% CI 0.784–1.543, P = 0.581). We concluded that self-reported PD was significantly more frequent in CM compared to EM. Self-reported PD was associated with the presence of CM, although some comorbidities shared by both diseases could have an effect on this association.

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Acknowledgements

Yago Leira holds a Senior Clinical Research Fellowship supported by the UCL Biomedical Research Centre.

Funding

This study was partially supported by grants from the Spanish Ministry of Economy and Competitiveness—Institute of Health Carlos III (PI15/01578). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Author notes

  1. Rogelio Leira and Francesco D’Aiuto contributed equally as joint senior authors.

Authors and Affiliations

  1. Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    Yago Leira, Marco Orlandi & Francesco D’Aiuto

  2. Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

    Yago Leira & Juan Blanco

  3. Headache Unit, Neurology Department, Vall d’Hebron University Hospital, Barcelona, Spain

    Patricia Pozo-Rosich & Marta Torres-Ferrús

  4. Headache Research Group, Vall d’Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain

    Patricia Pozo-Rosich & Marta Torres-Ferrús

  5. Department of Neurology, Hospital Clínico Universitario, Universidad Católica de Valencia, Valencia, Spain

    José Miguel Láinez

  6. Hospital Universitario Basurto, Universidad del País Vasco/Euskal Herriko Unibertsitatea EHU/UPV, Bilbao, Spain

    Luis Carlos Álvaro

  7. Hospital Universitario Miguel Servet, Zaragoza, Spain

    María José Monzón

  8. Hospital Clínico Universitario de Valladolid, Valladolid, Spain

    Ángel Guerrero & David García-Azorín

  9. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    Roberto Belvís

  10. Hospital Universitario Virgen del Rocío, Sevilla, Spain

    Carmen González-Oria

  11. Hospital Universitario La Princesa, Madrid, Spain

    Ana Beatriz Gago-Veiga

  12. Hospital Universitario de Fuenlabrada, Madrid, Spain

    Germán Latorre

  13. Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

    Sonia Santos

  14. Department of Neurology, Headache Unit, Hospital Clínico San Carlos, San Carlos Institute for Health Research (IdISSC), Complutense University of Madrid, Madrid, Spain

    María Luz Cuadrado

  15. Department of Neurology, Headache Unit, Hospital Clínico Universitario, University of Santiago de Compostela, Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

    Rogelio Leira

Authors
  1. Yago Leira
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  2. Patricia Pozo-Rosich
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  3. Marta Torres-Ferrús
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  4. Marco Orlandi
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  5. José Miguel Láinez
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  6. Luis Carlos Álvaro
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  7. María José Monzón
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  8. Ángel Guerrero
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  9. David García-Azorín
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  10. Roberto Belvís
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  11. Carmen González-Oria
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  12. Ana Beatriz Gago-Veiga
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  13. Germán Latorre
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  14. Sonia Santos
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  15. María Luz Cuadrado
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  16. Juan Blanco
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  17. Rogelio Leira
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  18. Francesco D’Aiuto
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Corresponding author

Correspondence to Yago Leira.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all the individual participants included in the study.

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Leira, Y., Pozo-Rosich, P., Torres-Ferrús, M. et al. Self-reported periodontitis and migraine: results from a multicenter, cross-sectional survey in Spain. Odontology 107, 530–535 (2019). https://doi.org/10.1007/s10266-019-00430-w

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  • DOI: https://doi.org/10.1007/s10266-019-00430-w

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