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Association of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of gender

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Abstract

Background

Depression is common in chronic kidney disease (CKD) patients and associated with significant increase in morbidity and mortality. In recent years, a relationship between vitamin D deficiency and depression has been shown. The aim of this study is to investigate the relationship between 25-hydroxy (OH) vitamin D and depression in hemodialysis patients.

Methods

A total of 140 patients were included in the study. Hamilton depression scale (HAM-D) was completed by all patients. 25(OH) vitamin D levels were compared between patients with and without depressive symptoms.

Results

Patients who had depressive symptoms had significantly lower 25(OH) vitamin D levels (13.70 [24.3–8.25] vs. 18.20 [29.2–11.7] ng/mL, p = 0.016). HAM-D score showed significant association with gender (p = 0.011) and 25(OH) vitamin D level (p = 0.011). Univariate logistic regression analysis showed that males had lower risk of depression by a ratio of 61.1% (OR 0.389, p = 0.012) and vitamin D-deficient patients had 2.88 times greater risk of depression compared to non-deficient patients (OR 2.885, p = 0.013). Multivariate logistic regression analysis showed that males had 53.7% less risk of depression (OR 0.463, p = 0.046) and vitamin D-deficient patients had 2.39 times greater risk of depression (OR 2.397, p = 0.047). When evaluated by gender, univariate logistic regression analysis showed that 25(OH) vitamin D and other variables were not associated with depression in females (p > 0.05), while only vitamin D level had a significant effect on depression in males (OR 8.207, p = 0.008).

Conclusions

We found a significant association between vitamin D level and depressive symptoms in hemodialysis patients. When analyzed according to gender, this association was found to stand independent of other variables only in males.

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Authors and Affiliations

  1. Internal Medicine Department, Selcuk University Faculty of Medicine, Konya, Turkey

    Yasemin Coskun Yavuz, Zeynep Biyik & Lutfullah Altintepe

  2. Internal Medicine Department, Konya Training and Research Hospital, Konya, Turkey

    Durmus Ozkul

  3. Biochemistry Department, Selcuk University Faculty of Medicine, Konya, Turkey

    Sedat Abusoglu, Duygu Eryavuz & Mikail Dag

  4. Nephrology Department, Konya Training and Research Hospital, Konya, Turkey

    Ibrahim Guney

  5. Statistics Department, Selcuk University Faculty of Science, Konya, Turkey

    Muslu Kazim Korez

  6. Nephrology Department, Selcuk University Faculty of Medicine, Konya, Turkey

    Yasemin Coskun Yavuz

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  1. Yasemin Coskun Yavuz
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Correspondence to Yasemin Coskun Yavuz.

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The authors have declared that no conflict of interest exists.

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The study was approved by the Ethics Advisory Committee of the Selcuk University (approval number: 201944).

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Informed consent was obtained from all patients (oral and written).

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Yavuz, Y.C., Biyik, Z., Ozkul, D. et al. Association of depressive symptoms with 25(OH) vitamin D in hemodialysis patients and effect of gender. Clin Exp Nephrol 24, 63–72 (2020). https://doi.org/10.1007/s10157-019-01794-7

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  • DOI: https://doi.org/10.1007/s10157-019-01794-7

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