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Change in the quality of life of caregivers of pediatric department patients undergoing kidney transplantation: a single-center prospective study

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Abstract

Background

Caregivers of patients with chronic kidney disease experience great burdens. Changes in these caregivers’ quality of life (QOL) before and after their children underwent kidney transplantation (KTx) were evaluated in this prospective study.

Methods

The sequential QOL scores of 31 caregivers (median age 38.5 years) whose children (5.8 years) underwent KTx from 2012 to 2014 were studied. The same questionnaires were administered before and 1, 3, and 12 months after KTx. We evaluated whether the following factors were associated with QOL: pre-transplant dialysis, recipient’s mental and/or motor disability, and acute rejection or infections after KTx.

Results

The average QOL score before KTx (3.40) was higher than that of the general population (3.23). Despite a temporal decrease at 1 month (3.15), the final QOL scores were maintained at 3 months (3.40) and 1 year (3.42) after KTx. The mean QOL scores were significantly higher for caregivers of patients with than without dialysis before KTx [3.46 vs. 3.28 (p = 0.041) at 3 months and 3.53 vs. 3.18 (p = 0.001) at 1 year, respectively]. Conversely, these scores were significantly lower for caregivers of patients with than without disabilities [2.97 vs. 3.20 (p = 0.021) at 1 month, 3.18 vs. 3.46 (p = 0.006) at 3 months, and 3.10 vs. 3.50 (p = 0.001) at 1 year, respectively].

Conclusion

Dialysis of children before KTx was a particularly larger burden for caregivers. The child’s comorbidities and social adaptation problems might be focused after KTx, we need to evaluate for more long-term QOL of caregivers.

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References

  1. Rees L. Long-term outcome after renal transplantation in childhood. Pediatr Nephrol. 2009;24:475–84.

    Article  Google Scholar 

  2. Shapiro R, Sarwal MM. Pediatric kidney transplantation. Pediatr Clin North Am. 2010;57:393–400.

    Article  Google Scholar 

  3. Manificat S, Dazord A, Cochat P, Morin D, Plainguet F, Debray D. Quality of life of children and adolescents after kidney or liver transplantation: child, parents and caregiver’s point of view. Pediatr Transplant. 2003;7:228–35.

    Article  CAS  Google Scholar 

  4. Shrestha A, Shrestha A, Basarab Horwath C, McKane W, Shrestha B, Raftery A. Quality of life following live donor renal transplantation: a single centre experience. Ann Transplant. 2010;15:5–10.

    Article  Google Scholar 

  5. Timmerman L, Zuidema WC, Erdman RA, Kranenburg LW, Timman R, Ijzermans JN, et al. Psychologic functioning of unspecified anonymous living kidney donors before and after donation. Transplantation. 2013;95:1369–74.

    Article  Google Scholar 

  6. Glotzer OS, Singh TP, Gallichio MH, Conti DJ, Siparsky NF. Long-term quality of life after living kidney donation. Transplant Proc. 2013;45:3225–3228.

    Article  CAS  Google Scholar 

  7. Hildebrand L, Melchert TP, Anderson RC. Impression management during evaluation and psychological reactions post-donation of living kidney donors. Clin Transplant. 2014;28:855–61.

    Article  Google Scholar 

  8. Tumin M, Abdul Talib Abdul Mutalib M, Mohd Satar N, Abdullah N, Chong CS, Ng KP, et al. A comparison of donor and control group quality of life. Ann Transplant. 2014;19:112–8.

    Article  CAS  Google Scholar 

  9. Hasegawa A, Oshima S, Takahashi K, Uchida K, Ito K, Sonoda T. Improvement of quality of life in tacrolimus-based pediatric renal transplant recipients and their caregivers, including donors. Transplant Proc. 2005;37:1771–1773.

    Article  CAS  Google Scholar 

  10. Diseth TH, Tangeraas T, Reinfjell T, Bjerre A. Kidney transplantation in childhood: mental health and quality of life of children and caregivers. Pediatr Nephrol. 2011;26:1881–92.

    Article  Google Scholar 

  11. Nakane M, Tazaki M, Miyaoka E. Distribution of the QOL score in the general population: Using WHOQOL. Med Soc. 1999;9:123–31 (in Japanese).

    Google Scholar 

  12. Uemura O, Nagai T, Ishikura K, Ito S, Hataya H, Gotoh Y, et al. Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease. Clin Exp Nephrol. 2014;18:626–33.

    Article  CAS  Google Scholar 

  13. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982–92.

    Article  CAS  Google Scholar 

  14. Neuhaus TJ, Wartmann M, Weber M, Landolt MA, Laube GF, Kemper MJ. Psychosocial impact of living-related kidney transplantation on donors and partners. Pediatr Nephrol. 2005;20:205–9.

    Article  Google Scholar 

  15. Clemens KK, Thiessen Philbrook H, Parikh CR, Yang RC, Karley ML, Boudville N, et al. Psychosocial health of living kidney donors: a systematic review. Am J Transplant. 2006;6:2965–77.

    Article  CAS  Google Scholar 

  16. Wiedebusch S, Konrad M, Foppe H, Reichwald Klugger E, Schaefer F, Schreiber V, et al. Health-related quality of life, psychosocial strains, and coping in parents of children with chronic renal failure. Pediatr Nephrol. 2010;25:1477–85.

    Article  Google Scholar 

  17. Madden SJ, Hastings RP, V’ant Hoff W. Psychological adjustment in children with end stage renal disease: the impact of maternal stress and coping. Child Care Health Dev. 2002;28:323–30.

    Article  CAS  Google Scholar 

  18. Ohta T, Motoyama O, Takahashi K, Hattori M, Shishido S, Wada N, et al. Kidney transplantation in pediatric recipients with mental retardation: clinical results of a multicenter experience in Japan. Am J Kidney Dis. 2006;47:518–27.

    Article  Google Scholar 

  19. Gjertson DW, Cecka JM. Determinants of long-term survival of pediatric kidney grafts reported to the United Network for Organ Sharing kidney transplant registry. Pediatr Transplant. 2001;5:5–15.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Angela Morben, DVM, and ELS from Edanz Group (http://www.edanzediting.com/ac) for editing a draft of this manuscript.

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Correspondence to Yuko Hamasaki.

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Conflict of interest

Yuko Hamasaki belongs to an endowed department sponsored by Asahi Kasei Pharma Corporation, Novartis Pharma K.K., Chugai Pharmaceutical Co., and Astellas Pharma. Ken Sakai received annual consultant fees from JMS Co. Ltd. The other authors have no potential conflicts of interest to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by a central ethics board at Toho University Omori Medical Center, the principal investigator’s institution (approval number: 24-124).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Hamasaki, Y., Yamaguchi, T., Takahashi, Y. et al. Change in the quality of life of caregivers of pediatric department patients undergoing kidney transplantation: a single-center prospective study. Clin Exp Nephrol 22, 1198–1204 (2018). https://doi.org/10.1007/s10157-018-1604-0

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  • DOI: https://doi.org/10.1007/s10157-018-1604-0

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