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Surgical outcomes of early-stage primary vaginal nonsquamous cell carcinoma

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Abstract

Objective

Definitive radiation therapy (RT), using external beam RT and/or brachytherapy, is a standard treatment option for primary vaginal carcinoma. However, this treatment has poor prognosis when applied to vaginal nonsquamous cell carcinoma (non-SCC). We aimed to clarify treatment outcome and surgical safety in early-stage primary vaginal non-SCC.

Methods

After receiving approval from the institutional review board, we retrospectively reviewed the clinical records and pathological samples of patients treated at our hospital between 1991 and 2018. Among 49 patients with primary vaginal carcinoma, 12 with histologically confirmed early-stage primary vaginal non-SCC were included in this study.

Results

In total, 40% of patients with primary vaginal carcinoma treated at our hospital had primary vaginal non-SCC. The average observation time was 34 months (median 53.3 months). Three patients had local recurrence: 2 in pelvic lymph nodes and 1 in the vagina. Furthermore, 2 patients died of their disease. Five-year local control rate of stage I and stage II non-SCC was 75% and 100%, respectively. Disease-specific survival rate of stage I and stage II non-SCC was 81.8% and 100%, respectively. No major morbidity was observed. Three patients required allogeneic blood transfusion, whereas 1 underwent autotransfusion. None of the 12 patients were discharged with self-catheterization.

Conclusion

Five-year local control and disease-specific survival rates of patients surgically treated for vaginal non-SCC were favorable. Therefore, surgery could be a safe and reasonable option for early-stage primary vaginal non-SCC.

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Authors and Affiliations

  1. Department of Gynecology, Cancer Institute Hospital, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan

    Hidetaka Nomura, Yuji Tanaka, Makiko Omi, Sachiho Netsu, Yoichi Aoki, Terumi Tanigawa, Tomoko Kurita, Maki Matoda, Sanshiro Okamoto, Kohei Omatsu, Hiroyuki Kanao & Nobuhiro Takeshima

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  1. Hidetaka Nomura
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  2. Yuji Tanaka
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  3. Makiko Omi
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  4. Sachiho Netsu
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  5. Yoichi Aoki
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  6. Terumi Tanigawa
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  7. Tomoko Kurita
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  8. Maki Matoda
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  9. Sanshiro Okamoto
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  12. Nobuhiro Takeshima
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Correspondence to Hidetaka Nomura.

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Nomura, H., Tanaka, Y., Omi, M. et al. Surgical outcomes of early-stage primary vaginal nonsquamous cell carcinoma. Int J Clin Oncol 25, 1412–1417 (2020). https://doi.org/10.1007/s10147-020-01663-4

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  • DOI: https://doi.org/10.1007/s10147-020-01663-4

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